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Oxidative Medicine and Cellular Longevity

Oxidative Medicine and Cellular Longevity

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Temporary Upregulation of Nrf2 by Naringenin Alleviates Oxidative Damage in the Retina and ARPE-19 Cells

Published:17 November 2021 DOI: 10.1155/2021/4053276 PMID: 34840667
Wenpei Chen, Yuxin Ye, Zhongrui Wu, Junli Lin, Yiting Wang, Qi Ding, Xinrong Yang, Wei Yang, Bingqing Lin, Baoqin Lin

Abstract

Dry age-related macular degeneration (dAMD) is a chronic degenerative ophthalmopathy that leads to serious burden of visual impairment. Antioxidation in retinal pigment epithelium (RPE) cells is considered as a potential treatment for dAMD. Our previous studies have showed that naringenin (NAR) protects RPE cells from oxidative damage partly through SIRT1-mediated antioxidation. In this study, we tested the hypothesis that the Nrf2 signaling is another protective mechanism of NAR on dAMD. NaIO3-induced mouse retinopathy and ARPE-19 cell injury models were established. Immunochemical staining, immunofluorescence, and western blotting were performed to detect the protein expressions of Nrf2 and HO-1. In addition, ML385 (activity inhibitor of Nrf2) and zinc protoporphyrin (ZnPP, activity inhibitor of HO-1) were applied to explore the effect of NaIO3 or NAR. The results showed that NAR increased the protein expressions of Nrf2 and HO-1 in the retinas in mice exposed to NaIO3 at the early stage. NAR treatment also resulted in a stronger activation of Nrf2 at the early stage in NaIO3-treated ARPE-19 cells. Moreover, inhibition of HO-1 by ZnPP weakened the cytoprotective effect of NAR. The constitutive accumulation and activation of Nrf2 induced by NaIO3 led to the death of RPE cells. However, NAR decreased the protein expressions of Nrf2 and HO-1 towards normal level in the mouse retinas and ARPE-19 cells exposed to NaIO3 at the late stage. Our findings indicate that NAR protects RPE cells from oxidative damage via activating the Nrf2 signaling pathway.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
ML385 846557-71-9 C29H25N3O4S 157 suppliers $18.00-$2646.00
ML385 846557-71-9 C29H25N3O4S 157 suppliers $18.00-$2646.00
ML385 846557-71-9 C29H25N3O4S 157 suppliers $18.00-$2646.00
ML385 846557-71-9 C29H25N3O4S 157 suppliers $18.00-$2646.00

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