一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> AAPS PharmSciTech >>article
AAPS PharmSciTech

AAPS PharmSciTech

IF: 3.4
Download PDF

Self-Emulsifying Drug Delivery System Enhances Tissue Distribution of Cinnamaldehyde by Altering the Properties of the Mucus Layer

Published:21 September 2022 DOI: 10.1208/s12249-022-02416-4 PMID: 36131215
Liu Liu, Wenxuan Cao, Mengqiu Xia, Chunling Tian, Wenqing Wu, Ye Cai, Xiaoqin Chu

Abstract

Oral delivery is considered the preferred route of administration due to its convenience and favorable compliance. However, this delivery often faces difficulties, such as poor solubility, limited absorption, and undesirable stability, especially for some volatile oils. The aim of this study was to develop self-emulsifying drug delivery systems (SEDDS) containing cinnamaldehyde (CA) to overcome these shortcomings. The CA-SEDDS were spherical and smooth with an average size of 14.96?±?0.18 nm. Differential scanning calorimetry (DSC) and attenuated total reflection by Fourier transform infrared (ATR-FTIR) showed that CA has been successfully loaded into SEDDS. The accumulative release of CA-SEDDS (73.39%) was approximately 2.14-fold that of free CA when using simulated intestinal fluid as the release medium. A scanning electron microscope was used to observe the mucus network structure. Rheological tests found that CA-SEDDS can appropriately enhance the viscosity of the mucus system. We found from tissue distribution studies that CA was more widely distributed in various tissues in the CA-SEDDS group compared to the free CA group. The cinnamaldehyde and cinnamon acid also accumulated more in various tissues in the CA-SEDDS group than in the free CA group, especially in the kidney. These findings hinted that SEDDS exhibited lower irritation, good release, and penetration, which demonstrated great potential for utilizing CA. Our research supports the rational implications of SEDDS in delivering similar volatile substances by improving the solubility, mucus penetration, and stability, resulting in excellent clinical efficacy.

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Urethane 51-79-6 C3H7NO2 599 suppliers $10.00-$3589.98
Urethane 51-79-6 C3H7NO2 599 suppliers $10.00-$3589.98
Urethane 51-79-6 C3H7NO2 599 suppliers $10.00-$3589.98
Urethane 51-79-6 C3H7NO2 599 suppliers $10.00-$3589.98
Ethyl carbamate 51-79-6 C3H7NO2 - Inquiry
Ethyl carbamate 51-79-6 C3H7NO2 - Inquiry

Similar articles

IF:5.3

Self-nanoemulsifying drug delivery systems of tamoxifen citrate: Design and optimization

International Journal of Pharmaceutics Yosra S.R. Elnaggar, Magda A. El-Massik,etc Published: 1 October 2009
IF:2.6

Anti-inflammatory and tissue repair effect of cinnamaldehyde and nano cinnamaldehyde on gingival fibroblasts and macrophages

BMC Oral Health Mostafa Ghardashpour, Majid Saeedi,etc Published: 19 December 2023
IF:4.1

Degradation of nonphenolic lignin by the laccase/1-hydroxybenzotriazole system

Journal of biotechnology Ewald Srebotnik , Kenneth E Hammel,etc Published: 25 August 2000
安岳县| 海阳市| 禄丰县| 双城市| 哈巴河县| 叶城县| 卫辉市| 犍为县| 会昌县| 吉木萨尔县| 贺州市| 敦化市| 南投市| 松原市| 宜昌市| 察雅县| 卓资县| 永泰县| 琼海市| 正安县| 香格里拉县| 方山县| 明水县| 唐河县| 五莲县| 阜阳市| 鄂伦春自治旗| 楚雄市| 黄冈市| 荆州市| 洪泽县| 巴马| 威宁| 腾冲县| 新乡县| 焉耆| 遂溪县| 林甸县| 大埔区| 宁陵县| 吉隆县|