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Journal of Trace Elements in Medicine and Biology

Journal of Trace Elements in Medicine and Biology

IF: 3.6
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Neodymium oxide nanostructures and their cytotoxic evaluation in human cancer cells

Published:1 September 2022 DOI: 10.1016/j.jtemb.2022.127029 PMID: 35785590
Javed Ahmad , Rizwan Wahab , Maqsood A. Siddiqui , Nida Nayyar Farshori , Quaiser Saquib , Naushad Ahmad , Abdulaziz A. Al-Khedhairy

Abstract

Neodymium oxide exhibits a unique property, which facilitates and largely utilized as an industrial applications. A number of cytotoxic study is available but very limited information is available to understand their biological activity with neodymium oxide at a very low conc- entration of the material. The present work was designed to understand the cytotoxicity against liver (HepG-2) and lung (A-549) cancer cells. Initially, Neodymium oxides (Nd2O3) were prepared and characterized with various instruments. The crystallinity and morphology of Nd2O3 powder were examined with instruments such as X-Ray Diffraction (XRD), scanning electron microscope (SEM), Transmission electron microscopy (TEM), Energy Dispersive X-Ray Analysis (EDX) respectively, revealed the size of curved nanostructure are ~140?±?2 in diameter whereas length goes upto ~700?nm with elemental composition. The cytotoxicity study was conducted with MTT, NRU assay with genotoxicity study via ROS, cell cycle and qPCR analysis. The cells cytotoxic assessment were analysed via MTT(3-(4,5-Dimethylthiazol-2-yl)??2,5-Diphenyl tetra zolium Bromide) and Neutral Red Uptake (NRU) assay with neodymium oxide (Nd2O3), which indicates the reduction in cell viability. Additionally, cell-cycle analysis showed an increase in the apoptotic peak after a 24-h. Quantitative real-time PCR (RT-PCR) data revealed that apoptotic genes such as p53, bax, and caspase-3 were up regulated, whereas bcl-2, an anti-apoptotic gene, was down regulated; therefore, apoptosis was mediated through ROS and genotoxicity pathways. The experiments of cytotoxicity was tested and concludes that the Nd2O3 express a moderate and dose dependent effect on cancer cells. The ROS, cell cycle analysis and qPCR showed that Nd2O3 exhibit the capability to cells death via ROS generation and genotoxicity study pathways.

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Procduct Name CAS Molecular Formula Supplier Price
Diphenhydramine Hydrochloride 147-24-0 C17H22ClNO 782 suppliers $5.00-$1593.90
Thiazolyl Blue 298-93-1 C18H16N5S.Br 608 suppliers $7.00-$1850.00
Neodymium oxide 1313-97-9 Nd2O3 392 suppliers $8.00-$2571.03
P53 C36H80O10P4Tc+ 83 suppliers $286.00-$824.00
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