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Nutrients

Nutrients

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Genome-Wide Transcriptional Profiling Reveals PHACTR1 as a Novel Molecular Target of Resveratrol in Endothelial Homeostasis

Published:27 October 2022 DOI: 10.3390/nu14214518 PMID: 36364780
Meiming Su, Wenqi Zhao, Yujie Li, Hong Li, Suowen Xu, Jianping Weng

Abstract

Atherosclerosis is a chronic inflammatory vascular disease in which endothelial cells play an important role in maintaining vascular homeostasis. Endotheliitis caused by endothelial dysfunction (ED) is the key cause for the development of cardiovascular and cerebrovascular diseases as well as other vascular system diseases. Resveratrol (RES), a multi-functional polyphenol present in edible plants and fruits, prevents cardiovascular disease by regulating a variety of athero-relevant signaling pathways. By transcriptome profiling of RES-treated human umbilical vein endothelial cells (HUVECs) and in-depth bioinformatic analysis, we observed that differentially expressed genes (DEGs) were enriched in KEGG pathways of fluid shear stress and atherosclerosis, suggesting that the RES may serve as a good template for a shear stress mimetic drug that hold promise in combating atherosclerosis. A heat map and multiple datasets superimposed screening revealed that RES significantly down-regulated phosphatase and actin modulator 1 (PHACTR1), a pivotal coronary artery disease risk gene associated with endothelial inflammation and polyvascular diseases. We further demonstrate that RES down-regulated the gene and protein expression of PHACTR1 and inhibited TNF-α-induced adhesion of THP-1 monocytes to activated endothelial cells via suppressing the expression of PHACTR1. Taken together, our study reveals that PHACTR1 represents a new molecular target for RES to maintain endothelial cell homeostasis and prevent atherosclerotic cardiovascular disease.

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Materials
Procduct Name CAS Molecular Formula Supplier Price
Resveratrol 501-36-0 C14H12O3 1359 suppliers $5.00-$5653.00
Resveratrol 501-36-0 C14H12O3 1359 suppliers $5.00-$5653.00
Resveratrol 501-36-0 C14H12O3 1359 suppliers $5.00-$5653.00
Resveratrol 501-36-0 C14H12O3 1359 suppliers $5.00-$5653.00
Resveratrol 501-36-0 - Inquiry
Resveratrol 501-36-0 - Inquiry
Resveratrol 98% 501-36-0 C14H12O3 - Inquiry
Resveratrol 98% 501-36-0 C14H12O3 - Inquiry
Resveratrol 501-36-0 - Inquiry
Resveratrol 501-36-0 - Inquiry

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