一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Small Methods >>article
Small Methods

Small Methods

IF: 10.7
Download PDF

Characterization of Cancer Cell Mechanics by Measuring Active Deformation Behavior

Published:29 September 2023 DOI: 10.1002/smtd.202300520 PMID: 37775303
Jiantao Feng, Quanmei Sun, Peipei Chen, Keli Ren, Yuanyuan Zhang, Yahong Shi, Songkun Gao, Zhiwei Song, Jigang Wang, Fulong Liao, Dong Han

Abstract

Active deformation behavior reflects cell structural dynamics adapting to varying environmental constraints during malignancy progression. In most cases, cell mechanics is characterized by modeling using static equilibrium?systems, which fails to comprehend cell deformation behavior leading to inaccuracies in distinguishing cancer cells from normal cells. Here, a method is introduced to measure the active deformation behavior of cancer cells using atomic force microscopy (AFM) and the newly developed deformation behavior cytometry (DBC). During the measurement, cells are deformed and allows a long timescale relaxation (≈5 s). Two parameters are derived to represent deformation behavior: apparent Poisson's ratio for adherent cells, which is measured with AFM and refers to the ratio of the lateral strain to the longitudinal strain of the cell, and shape recovery for suspended cells, which is measured with DBC. Active deformation behavior defines cancer cell mechanics better than traditional mechanical parameters (e.g., stiffness, diffusion, and viscosity). Additionally, aquaporins are essential for promoting the deformation behavior, while the actin cytoskeleton acts as a downstream effector. Therefore, the potential application of the cancer cell active deformation behavior as a biomechanical marker or therapeutic target in cancer treatment should be evaluated.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Bacopaside II 382146-66-9 C47H76O18 102 suppliers $81.00-$1090.00
Bacopaside II 382146-66-9 C47H76O18 102 suppliers $81.00-$1090.00
Bacopaside II 382146-66-9 C47H76O18 102 suppliers $81.00-$1090.00
Bacopaside II 382146-66-9 C47H76O18 102 suppliers $81.00-$1090.00

Similar articles

IF:12.7

Capmatinib (INC280) Is Active Against Models of Non-Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation.

ACS Central Science Sabrina Baltschukat, Barbara Schacher Engstler,etc Published: 15 May 2019
IF:5.3

Preparation and characterization of Tamoxifen citrate loaded nanoparticles for breast cancer therapy.

ACS Applied Nano Materials Ruma Maji, Niladri Shekhar Dey,etc Published: 25 June 2014
迁安市| 徐闻县| 崇州市| 德钦县| 正宁县| 婺源县| 宿松县| 城口县| 土默特右旗| 盐池县| 石城县| 石嘴山市| 津市市| 黔东| 和林格尔县| 神农架林区| 彭泽县| 海南省| 郁南县| 那坡县| 垫江县| 顺昌县| 含山县| 建昌县| 诸暨市| 集贤县| 晋城| 志丹县| 静乐县| 岫岩| 弥勒县| 金寨县| 温宿县| 勃利县| 宣威市| 巢湖市| 南充市| 邢台县| 建宁县| 华亭县| 德兴市|