一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Cellular signalling >>article
Cellular signalling

Cellular signalling

IF: 4.4
Download PDF

Phosphorylated Hsp27 promotes adriamycin resistance in breast cancer cells through regulating dual phosphorylation of c-Myc

Published:4 October 2023 DOI: 10.1016/j.cellsig.2023.110913 PMID: 37797796
Xiaowen Bi , Miao Zhang , Jinyi Zhou , Xintong Yan , Lixia Cheng , Lan Luo , Chunhong Huang , Zhimin Yin

Abstract

Chemotherapy resistance of breast cancer cells is one of the major factors affecting patient survival rate. Heat shock protein 27 (Hsp27) is a member of the small heat shock protein family that has been reported to be associated with chemotherapy resistance in tumor cells, but the exact mechanism is not fully understood. Here, we explored the regulation of Hsp27 in adriamycin-resistant pathological conditions of breast cancer in vitro and in vivo. We found that overexpression of Hsp27 in MCF-7 breast cancer cells reversed DNA damage induced by adriamycin, and thereby reduced subsequent cell apoptosis. Non-phosphorylated Hsp27 accelerated ubiquitin-mediated degradation of c-Myc under normal physiological conditions. After stimulation with adriamycin, Hsp27 was phosphorylated and translocated from the cytoplasm into the nucleus, where phosphorylated Hsp27 upregulated c-Myc and Nijmegen breakage syndrome 1 (NBS1) protein levels thus leading to ATM activation. We further showed that phosphorylated Hsp27 promoted c-Myc nuclear import and stabilization by regulating T58/S62 phosphorylation of c-Myc through a protein phosphatase 2A (PP2A)-dependent mechanism. Collectively, the data presented in this study demonstrate that Hsp27, in its phosphorylation state, plays a critical role in adriamycin-resistant pathological conditions of breast cancer cells.

Substances (20)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Doxorubicin hydrochloride 25316-40-9 C27H29NO11.ClH 956 suppliers $15.00-$7060.00
Doxorubicin hydrochloride 25316-40-9 C27H29NO11.ClH 956 suppliers $15.00-$7060.00
Doxorubicin hydrochloride 25316-40-9 C27H29NO11.ClH 956 suppliers $15.00-$7060.00
Doxorubicin hydrochloride 25316-40-9 C27H29NO11.ClH 956 suppliers $15.00-$7060.00
KU-55933 587871-26-9 C21H17NO3S2 182 suppliers $14.00-$3176.25
KU-55933 587871-26-9 C21H17NO3S2 182 suppliers $14.00-$3176.25
KU-55933 587871-26-9 C21H17NO3S2 182 suppliers $14.00-$3176.25
KU-55933 587871-26-9 C21H17NO3S2 182 suppliers $14.00-$3176.25
(Z,E)-5-(4-ETHYLBENZYLIDINE)-2-THIOXOTHIAZOLIDIN-4-ONE 403811-55-2 C12H11NOS2 154 suppliers $19.00-$1654.10
(Z,E)-5-(4-ETHYLBENZYLIDINE)-2-THIOXOTHIAZOLIDIN-4-ONE 403811-55-2 C12H11NOS2 154 suppliers $19.00-$1654.10

Similar articles

IF:4.5

FMNL3 Promotes Migration and Invasion of Breast Cancer Cells via Inhibiting Rad23B‐Induced Ubiquitination of Twist1

Journal of Cellular Physiology Binggong Zhao, Dong‐Man Ye,etc Published: 25 November 2024
IF:4.8

Rocaglamide reprograms glucose metabolism in erythroleukemic cells via c-MYC transcriptional regulation of TXNIP and HK2

Journal of ethnopharmacology Jialei Song, Wuling Liu,etc Published: 21 November 2024
德钦县| 南投县| 利川市| 会东县| 镇坪县| 望江县| 嘉义市| 上犹县| 毕节市| 佛学| 孟州市| 玛曲县| 扎赉特旗| 达州市| 微博| 顺昌县| 怀集县| 武威市| 定日县| 观塘区| 渭源县| 墨玉县| 武功县| 惠来县| 汶上县| 诸暨市| 永和县| 博湖县| 祁东县| 宁化县| 乌鲁木齐县| 黔东| 楚雄市| 铁岭市| 大关县| 浠水县| 望都县| 商城县| 永靖县| 深州市| 海盐县|