一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Theranostics >>article
Theranostics

Theranostics

IF: 13.3
Download PDF

Metabolite Neu5Ac triggers SLC3A2 degradation promoting vascular endothelial ferroptosis and aggravates atherosclerosis progression in ApoE-/-mice

Published:4 September 2023 DOI: 10.7150/thno.87968 PMID: 37771765
Peng Xiang, Qingqiu Chen, Le Chen, Jin Lei, Zhiyi Yuan, Hui Hu, Yining Lu, Xianmin Wang, Tingting Wang, Ruihong Yu, Wanping Zhang, Jun Zhang, Chao Yu, Limei Ma

Abstract

Background: Atherosclerosis (AS) is still the major cause of cardiovascular disease (CVD) as well as stroke. Endothelial metabolic disorder has been found to be activated and then promote endothelial cells (ECs) injury, which is regarded to initiate AS progression. N-acetylneuraminic acid (Neu5Ac), a metabolite produced by hexosamine-sialic acid pathway branching from glucose metabolism, was presented as a notable biomarker of CVD and is positively correlated with ECs function. However, few studies explain whether Neu5Ac regulate AS progression by affecting EC function as well as its involved mechanisms are still unknown. Methods: Here, we mimicked an animal model in ApoE-/- mice which displaying similar plasma Neu5Ac levels with AS model to investigate its effect on AS progression. Results: We found that Neu5Ac exacerbated plaques area and increased lipids in plasma in absence of HFD feeding, and ECs inflammatory injury was supposed as the triggering factor upon Neu5Ac treatment with increasing expression of IL-1β, ICAM-1, and promoting ability of monocyte adhesion to ECs. Mechanistic studies showed that Neu5Ac facilitated SLC3A2 binding to ubiquitin and then triggered P62 mediated degradation, further leading to accumulation of lipid peroxidation in ECs. Fer-1 could inhibit ECs injury and reverse AS progression induced by Neu5Ac in ApoE-/- mice. Interestingly, mitochondrial dysfunction was also partly participated in ECs injury after Neu5Ac treatment and been reversed by Fer-1. Conclusions: Together, our study unveils a new mechanism by which evaluated metabolite Neu5Ac could promote SLC3A2 associated endothelial ferroptosis to activate ECs injury and AS plaque progression, thus providing a new insight into the role of Neu5Ac-ferroptosis pathway in AS. Also, our research revealed that pharmacological inhibition of ferroptosis may provide a novel therapeutic strategy for premature AS.

Substances (8)

Materials
Procduct Name CAS Molecular Formula Supplier Price
2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone 571203-78-6 C30H31ClN4O4 283 suppliers $16.00-$2691.10
2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone 571203-78-6 C30H31ClN4O4 283 suppliers $16.00-$2691.10
2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone 571203-78-6 C30H31ClN4O4 283 suppliers $16.00-$2691.10
2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone 571203-78-6 C30H31ClN4O4 283 suppliers $16.00-$2691.10
Ferrostatin-1 (Fer-1) 347174-05-4 C15H22N2O2 247 suppliers $10.00-$2822.00
Ferrostatin-1 (Fer-1) 347174-05-4 C15H22N2O2 247 suppliers $10.00-$2822.00
Ferrostatin-1 (Fer-1) 347174-05-4 C15H22N2O2 247 suppliers $10.00-$2822.00
Ferrostatin-1 (Fer-1) 347174-05-4 C15H22N2O2 247 suppliers $10.00-$2822.00

Similar articles

IF:3.2

Mechanisms of METTL14‐Mediated m6A Modification in Promoting Iron Overload‐Induced Lipid Peroxidative Damage in Vascular Endothelial Cells to Aggravate Atherosclerosis

Journal of Biochemical and Molecular Toxicology Xiao‐li Min, Si‐xian Lin,etc Published: 26 November 2024
IF:3

MiR-23a-3p targets PTEN as a novel anti-ferroptosis regulator in Fuchs endothelial corneal dystrophy

Experimental eye research Miaomiao Chi, Yaning Zhao,etc Published: 22 November 2024
IF:19.8

Generation of iPSC-derived human venous endothelial cells for the modeling of vascular malformations and drug discovery

Cell stem cell Zihang Pan, Qiyang Yao,etc Published: 22 November 2024
顺义区| 呼图壁县| 金华市| 建瓯市| 周宁县| 城口县| 湘潭县| 安泽县| 沛县| 定南县| 紫金县| 南岸区| 徐水县| 清苑县| 新绛县| 右玉县| 新闻| 临西县| 平凉市| 民丰县| 大理市| 洛隆县| 盐边县| 项城市| 于都县| 历史| 华宁县| 札达县| 张家港市| 涞源县| 南乐县| 大宁县| 达拉特旗| 垫江县| 南投县| 浮梁县| 历史| 京山县| 堆龙德庆县| 平潭县| 宜君县|