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Microbiology spectrum

Microbiology spectrum

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Proteomic analysis of anti-MRSA activity of caerin 1.1/1.9 in a murine skin infection model and their in vitro anti-biofilm effects against Acinetobacter baumannii

Published:12 December 2023 DOI: 10.1128/spectrum.04520-22 PMID: 37819110
Pingping Zhang,?Shuxian Tang,?Quanlan Fu,?Yuandong Luo,?Junjie Li,?Zhu Chen,?Hejie Li,?Guoying Ni,?Tianfang Wang,?Guoqiang Chen,?Xiaosong Liu

Abstract

Importance: Caerin 1.1 and caerin 1.9, natural antimicrobial peptides derived from tree frogs, have demonstrated the ability to inhibit the growth of antibiotic-resistant bacteria, comparable to certain widely used antibiotics. Additionally, these peptides exhibit the capacity to prevent or treat biofilms formed by bacteria in conjunction with bodily components. The mechanisms underlying their antibacterial effects were investigated through a mouse model of bacterial skin infection, utilizing proteomic analysis as a technological approach.

Substances (8)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Sodium fusidate 751-94-0 C31H49NaO6 396 suppliers $15.00-$2120.00
Sodium fusidate 751-94-0 C31H49NaO6 396 suppliers $15.00-$2120.00
Sodium fusidate 751-94-0 C31H49NaO6 396 suppliers $15.00-$2120.00
Sodium fusidate 751-94-0 C31H49NaO6 396 suppliers $15.00-$2120.00
Dalbavancin 171500-79-1 C88H100Cl2N10O28 223 suppliers $33.00-$3728.10
Dalbavancin 171500-79-1 C88H100Cl2N10O28 223 suppliers $33.00-$3728.10
Dalbavancin 171500-79-1 C88H100Cl2N10O28 223 suppliers $33.00-$3728.10
Dalbavancin 171500-79-1 C88H100Cl2N10O28 223 suppliers $33.00-$3728.10

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