一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Life sciences >>article
Life sciences

Life sciences

IF: 5.2
Download PDF

Lunasin ameliorates glucose utilization in C2C12 myotubes and metabolites profile in diet-induced obese mice benefiting metabolic disorders

Published:15 October 2023 DOI: 10.1016/j.lfs.2023.122180 PMID: 37848083
Pei-Ying Huang , Ching-Ching Chiang , Ching-Ya Huang , Pin-Yu Lin , Han-Chun Kuo , Ching-Hua Kuo , Chia-Chien Hsieh

Abstract

Aims

Obesity is the main cause of low-grade inflammation and oxidation, resulting in insulin resistance. This study aimed to investigate the effects of a seed peptide lunasin on glucose utilization in C2C12 myotubes and the metabolite profiles in obese mice.

Main methods

C2C12 myotubes were challenged by palmitic acid (PA) to mimic the obese microenvironment and inflammation, cell vitality, and glucose utilization were determined. C57BL6/j mice were divided into low-fat diet (LF), high-fat diet (HF), and HF with intraperitoneally injected lunasin (HFL) groups. Glucose intolerance and metabolite profiles of the tissues were analyzed.

Key findings

In vitro, C2C12 myotubes treated with lunasin showed decreased proinflammatory cytokines and increased cell vitality under palmitic acid conditions. Lunasin improved glucose uptake and glucose transporter 4 expression by activating insulin receptor substrate-1 and AKT phosphorylation. Next-generation sequencing revealed that lunasin regulates genes expression by promoting insulin secretion and decreasing oxidative stress. In vivo, HF mice showed increased tricarboxylic acid cycle and uric acid metabolites but decreased bile acids metabolites and specific amino acids. Lunasin intervention improved glucose intolerance and modulated metabolites associated with increased insulin sensitivity and decreased metabolic disorders.

Significance

This study is the first to reveal that lunasin is a promising regulator of anti-inflammation, anti-oxidation, and glucose utilization in myotubes and ameliorating glucose uptake and metabolite profiles in obese mice, contributing to glucose homeostasis and benefiting metabolic disorders.

Similar articles

IF:2.3

5′-CMP and 5′-UMP alleviate dexamethasone-induced muscular atrophy in C2C12 myotubes

Biochemistry and Biophysics Reports Kosuke Nakagawara , Chieri Takeuchi ,etc Published: 1 July 2023
IF:5.6

AICAR Improves Outcomes of Metabolic Syndrome and Type 2 Diabetes Induced by High-Fat Diet in C57Bl/6 Male Mice.

International Journal of Molecular Sciences Elena A Tukhovskaya, Elvira R Shaykhutdinova,etc Published: 11 December 2022
IF:3.3

Curcumin ameliorates astrocyte inflammation through AXL in cuprizone-induced mice

Toxicology and applied pharmacology Wenjing Zhang, Mengjiao Sun,etc Published: 23 November 2024
达拉特旗| 麻城市| 叙永县| 卢龙县| 盈江县| 乌拉特后旗| 竹山县| 纳雍县| 耿马| 盘锦市| 松江区| 那坡县| 长沙县| 融水| 沂南县| 合山市| 启东市| 温泉县| 西畴县| 牡丹江市| 灵寿县| 棋牌| 兴山县| 依安县| 工布江达县| 海口市| 大名县| 海盐县| 宁强县| 安平县| 滨州市| 芜湖市| 呈贡县| 铜川市| 绥阳县| 霍林郭勒市| 中山市| 南丹县| 沙洋县| 班玛县| 噶尔县|