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Oncogene

Oncogene

IF: 7.3
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PCDHB14 promotes ferroptosis and is a novel tumor suppressor in hepatocellular carcinoma.

Published:10 June 2022 DOI:
Yating Liu, Lianlian Ouyang, Chao Mao, Yuanbing Chen, Tiansheng Li, Na Liu, Zuli Wang, Weiwei Lai, Yanling Zhou, Ya Cao, Shuang Liu, Yinming Liang, Min Wang, Shouping Liu, Ling Chen, Ying Shi, Desheng Xiao, Yongguang Tao

Abstract

Liver cancer, a result of multifactorial interplay between heredity and the environment, is one of the leading causes of cancer-related death worldwide. Hepatocellular carcinoma (HCC) is the most common histologic type of primary liver cancer. Here, we reported that deficiency in PCDHB14, a member of the cadherin superfamily, participates in the progression of HCC. We found that PCDHB14 is inactivated by aberrant methylation of its promoter in HCC patients and that PCDHB14 functions as a tumor suppressor to promote cell cycle arrest, inhibit cell proliferation, and induce ferroptosis. Furthermore, PCDHB14 ablation dramatically enhanced diethylenenitrite-induced HCC development. Mechanistically, PCDHB14 is induced by p53, and increased PCDHB14 downregulates the expression of SLC7A11, which is critical for ferroptosis. This effect is mediated by accelerated p65 protein degradation resulting from PCDHB14 promoting E3 ubiquitin ligase RNF182-mediated ubiquitination of p65 to block p65 binding to the promoter of SLC7A11. This study reports the new discovery that PCDHB14 serves as a potential prognostic marker for HCC.

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Sorafenib 284461-73-0 C21H16ClF3N4O3 658 suppliers $8.00-$756.25
Sorafenib 284461-73-0 C21H16ClF3N4O3 658 suppliers $8.00-$756.25
Sorafenib 284461-73-0 C21H16ClF3N4O3 658 suppliers $8.00-$756.25
Sorafenib 284461-73-0 C21H16ClF3N4O3 658 suppliers $8.00-$756.25
Sorafenib 284461-73-0 - Inquiry
Sorafenib 284461-73-0 - Inquiry
2-?Pyridinecarboxamide, 4-?[4-?[[[[4-?chloro-?3-?(trifluoromethyl)?phenyl]?amino]?carbonyl]?amino]?phenoxy]?-?N-?methyl- 284461-73-0 - Inquiry
2-?Pyridinecarboxamide, 4-?[4-?[[[[4-?chloro-?3-?(trifluoromethyl)?phenyl]?amino]?carbonyl]?amino]?phenoxy]?-?N-?methyl- 284461-73-0 - Inquiry

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