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Drug Delivery

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Cubic and hexagonal liquid crystal gels for ocular delivery with enhanced effect of pilocarpine nitrate on anti-glaucoma treatment

Published:1 January 2019 DOI: 10.1080/10717544.2019.1667451
Wang Xingqi,?Z. Yong,?L. Xing,?Wang Yang,?H. Jie,?Huang Rongfeng,?Gui Shuangying,?Chu Xiaoqin

Abstract

Abstract The objective of this work was to investigate phytantriol-based liquid crystal (LC) gels including cubic (Q2) and hexagonal (H2) phase for ocular delivery of pilocarpine nitrate (PN) to treat glaucoma. The gels were produced by a vortex method and confirmed by crossed polarized light microscopy, small-angle X-ray scattering, and rheological measurements. Moreover, the release behaviors and permeation results of PN from the gels were estimated using in vitro studies. Finally, the anti-glaucoma effect of LC gels was evaluated by in vivo animal experiments. The inner structure of the gels was Pn3m-type Q2 and H2 phase, and both of them showed pseudoplastic fluid properties based on characterization techniques. In vitro release profiles suggested that PN could be sustainably released from LC gels within 48?h. Compared with eye drops, Q2 and H2 gel produces a 5.25-fold and 6.23-fold increase in the P app value (p?

Substances (5)

Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
Pilocarpine nitrate 148-72-1 C11H17N3O5 145 suppliers $22.40-$1730.00
Pilocarpine nitrate 148-72-1 C11H17N3O5 145 suppliers $22.40-$1730.00
Pilocarpine nitrate 148-72-1 C11H17N3O5 145 suppliers $22.40-$1730.00
Pilocarpine nitrate 148-72-1 C11H17N3O5 145 suppliers $22.40-$1730.00

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