一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Neurochemical Research >>article
Neurochemical Research

Neurochemical Research

IF: 3.7
Download PDF

A Synopsis of Multitarget Potential Therapeutic Effects of Huperzine A in Diverse Pathologies–Emphasis on Alzheimer’s Disease Pathogenesis

Published:5 February 2022 DOI: 10.1007/s11064-022-03530-2 PMID: 35122609
Mayuri Shukla, Prapimpun Wongchitrat, Piyarat Govitrapong

Abstract

Numerous challenges are confronted when it comes to the recognition of therapeutic agents for treating complex neurodegenerative diseases like Alzheimer’s disease (AD). The perplexing pathogenicity of AD embodies cholinergic dysfunction, amyloid beta (Aβ) aggregation, neurofibrillary tangle formation, neuroinflammation, mitochondrial disruption along with vicious production of reactive oxygen species (ROS) generating oxidative stress. In this frame of reference, drugs with multi target components could prove more advantageous to counter complex pathological mechanisms that are responsible for AD progression. For as much as, medicinal plant based pharmaco-therapies are emerging as potential candidates for AD treatment keeping the efficacy and safety parameters in terms of toxicity and side effects into consideration. Huperzine A (Hup A) is a purified alkaloid compound extracted from a club moss called Huperzia serrata. Several studies have reported both cholinergic and non-cholinergic effects of this compound on AD with significant neuroprotective properties. The present review convenes cumulative demonstrations of neuroprotection provided by Hup A in in vitro, in vivo, and human studies in various pathologies. The underlying molecular mechanisms of its actions have also been discussed. However, more profound evidence would certainly promote the therapeutic implementation of this drug thus furnishing decisive insights into AD therapeutics and various other pathologies along with preventive and curative management.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Huperzine A 120786-18-7 C15H18N2O 213 suppliers $62.00-$1200.00
(-)-HUPERZINE A C15H18N2O 12 suppliers Inquiry

Similar articles

IF:4.4

Palmitoylethanolamide (PEA) as a Potential Therapeutic Agent in Alzheimer’s Disease

Frontiers in Pharmacology S. Beggiato,?M. C. Tomasini,etc Published: 24 July 2019
IF:0

Therapeutic Potential of Isoflavones with an Emphasis on Daidzein.

Oxidative Medicine and Cellular Longevity Mohammed M Alshehri,?Javad Sharifi-Rad,etc Published: 9 September 2021
IF:5.4

Huperzine A and Its Neuroprotective Molecular Signaling in Alzheimer's Disease.

ACS Applied Energy Materials María Jesús Friedli, Nibaldo C Inestrosa,etc Published: 29 October 2021
沙田区| 平江县| 合江县| 绥芬河市| 阿克苏市| 嘉祥县| 蕉岭县| 武鸣县| 苍梧县| 缙云县| 宝清县| 永吉县| 台东市| 新野县| 博野县| 湘潭县| 健康| 崇州市| 鹤壁市| 牡丹江市| 佛坪县| 包头市| 班戈县| 南郑县| 铁岭县| 微山县| 定襄县| 襄汾县| 玉龙| 民和| 宁强县| 丰顺县| 醴陵市| 海安县| 洛阳市| 福建省| 论坛| 甘孜| 定陶县| 长子县| 凌云县|