一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Frontiers in Immunology >>article
Frontiers in Immunology

Frontiers in Immunology

IF: 5.7
Download PDF

Mechanistic Insight Into the Activation of the NLRP3 Inflammasome by Neisseria gonorrhoeae in Macrophages

Published:31 July 2019 DOI: 10.3389/fimmu.2019.01815
Lan-hui Li,?Jia-Sing Lin,?Hsiao-Wen Chiu,?Wen-Yu Lin,?Tz-Chuen Ju,?Fang-Hsin Chen,?O. Chernikov,?May-Lan Liu,?Jen-Che Chang,?Chung-Hua Hsu,?Ann Chen,?S. Ka,?Hong-wei Gao,?Kuo-Feng Hua

Abstract

Gonorrhea is a type III legal communicable disease caused by Neisseria gonorrhoeae (NG), one of the most common sexually transmitted bacteria worldwide. NG infection can cause urethritis or systemic inflammation and may lead to infertility or other complications. The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is a protein complex composed of NLRP3, apoptosis-associated speck-like protein and caspase-1 and is an important part of the cellular machinery controlling the release of interleukin (IL)-1β and IL-18 and the pathogenesis of numerous infectious diseases. It has been reported that NG infection activates the NLRP3 inflammasome; however, the underlying mechanism remain unclear. In this report, the signaling pathways involved in the regulation of NG-mediated NLRP3 inflammasome activation in macrophages were studied. The results indicated that viable NG, but not heat-killed or freeze/thaw-killed NG, activated the NLRP3 inflammasome in macrophages through toll-like receptor 2, but not toll-like receptor 4. NG infection provided the priming signal to the NLRP3 inflammasome that induced the expression of NLRP3 and IL-1β precursor through the nuclear factor kappa B and mitogen-activated protein kinase pathways. In addition, NG infection provided the activation signal to the NLRP3 inflammasome that activated caspase-1 through P2X7 receptor-dependent potassium efflux, lysosomal acidification, mitochondrial dysfunction, and reactive oxygen species production pathways. Furthermore, we demonstrated that NLRP3 knockout increased phagocytosis of bacteria by macrophages and increases the bactericidal activity of macrophages against NG. These findings provide potential molecular targets for the development of anti-inflammatory drugs that could ameliorate NG-mediated inflammation.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
MCC950 210826-40-7 C20H24N2O5S 139 suppliers $44.00-$1641.00
MCC950 210826-40-7 C20H24N2O5S 139 suppliers $44.00-$1641.00
MCC950 210826-40-7 C20H24N2O5S 139 suppliers $44.00-$1641.00
MCC950 210826-40-7 C20H24N2O5S 139 suppliers $44.00-$1641.00

Similar articles

IF:1.3

Insight into the role of pre-assembly and desolvation in crystal nucleation: a case of p-nitrobenzoic acid.

Acta crystallographica Section B, Structural science, crystal engineering and materials Shuyi Zong,?Jingkang Wang,etc Published: 1 October 2019
IF:3.3

Improvement in the Palladium-Catalyzed Miyaura Borylation Reaction by Optimization of the Base: Scope and Mechanistic Study

The Journal of Organic Chemistry Santiago Barroso, Markus Joksch,etc Published: 27 November 2020
洞口县| 定州市| 新宁县| 龙江县| 隆林| 新化县| 天水市| 洪湖市| 河间市| 金平| 琼海市| 凤城市| 郁南县| 合水县| 博客| 托克逊县| 淳化县| 通化县| 万宁市| 上虞市| 襄城县| 晋宁县| 岳阳县| 祥云县| 滦南县| 阿克| 开封市| 玛曲县| 富源县| 砀山县| 繁昌县| 临泉县| 改则县| 安陆市| 客服| 阿图什市| 应用必备| 乐昌市| 安达市| 阜南县| 五台县|