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Oncogene

Oncogene

IF: 7.3
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MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis

Published:8 November 2019 DOI: 10.1038/s41388-019-1090-1
Chaoyang Sun, Xi Li, Ensong Guo, Na Li, Bo Zhou, Hao Lu, Jia Huang, Meng Xia, Wanying Shan, Beibei Wang, Kezhen Li, Danhui Weng, Xiaoyan Xu, Qinglei Gao, Shixuan Wang, Junbo Hu, Yiling Lu, Gordon B. Mills, Gang Chen

Abstract

Ovarian cancer selective metastasizes to the omentum contributing to the poor prognosis associated with ovarian cancer. However, the mechanism underlining this propensity and therapeutic approaches to counter this process has not been fully elucidated. Here, we show that MCP-1 produced by omental adipocytes binding to its cognate receptor CCR-2 on ovarian cancer cells facilitates migration and omental metastasis by activating the PI3K/AKT/mTOR pathway and its downstream effectors HIF-1α and VEGF-A in cell lines, xenografts, and transgenic murine models. MCP-1 antibody significantly decreased tumor burden and increased survival of mice in vivo. Interestingly, metformin decreased omental metastasis at least partially by inhibiting MCP-1 secretion from adipocytes independent of direct effects on cancer cells. Together this suggests a novel target of MCP-1/CCR-2 axis that could benefit ovarian cancer patients.

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Procduct Name CAS Molecular Formula Supplier Price
Dexamethasone 50-02-2 C22H29FO5 942 suppliers $20.00-$5210.50
Dexamethasone 50-02-2 C22H29FO5 942 suppliers $20.00-$5210.50
Dexamethasone 50-02-2 C22H29FO5 942 suppliers $20.00-$5210.50
Dexamethasone 50-02-2 C22H29FO5 942 suppliers $20.00-$5210.50
3-ISOBUTYL-1-METHYLXANTHINE 28822-58-4 C10H14N4O2 392 suppliers $10.00-$4160.00
3-ISOBUTYL-1-METHYLXANTHINE 28822-58-4 C10H14N4O2 392 suppliers $10.00-$4160.00
3-ISOBUTYL-1-METHYLXANTHINE 28822-58-4 C10H14N4O2 392 suppliers $10.00-$4160.00
3-ISOBUTYL-1-METHYLXANTHINE 28822-58-4 C10H14N4O2 392 suppliers $10.00-$4160.00

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