一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> MedComm >>article

MedComm

IF: 10.7
Download PDF

Tyrosine phosphatase SHP2 exacerbates psoriasis-like skin inflammation in mice via ERK5-dependent NETosis.

Published:4 March 2022 DOI: 10.1002/mco2.120 PMID: 35281792
Yan Ding, Zijun Ouyang, Chenyang Zhang, Yuyu Zhu, Qiang Xu, Haiyan Sun, Jiao Qu, Yang Sun

Abstract

Psoriasis is a chronic inflammatory skin disease, often accompanied by increased infiltration of immune cells, especially neutrophils. However, the detailed mechanism of the neutrophil function in psoriasis progression remains unclear. Here, we found that both Src homology-2 domain-containing protein tyrosine phosphatase-2 (SHP2) and neutrophils were highly correlated to developing psoriasis by single-cell ribonucleic acid (RNA) sequencing and experiment verification. The deficiency of SHP2 in neutrophils significantly alleviated psoriasis-like phenotype in an imiquimod-induced murine model. Interestingly, high levels of neutrophil extracellular traps (NETs) were produced in the inflamed lesions of psoriatic patients. In addition, imiquimod-induced psoriasis-like symptoms were remarkably ameliorated in peptidyl arginine deiminase 4 (PAD4) knockout mice, which cannot form NETs. Mechanistically, RNA-seq analysis revealed that SHP2 promoted the formation of NETs in neutrophils via the ERK5 pathway. Functionally, this mechanism resulted in the infiltration of pro-inflammatory cytokines such as TNF-α, IL-1β, IL-6, IL-17A, and CXCL-15, which enhances the inflammatory response in skin lesions and reinforces the cross-talk between neutrophils and keratinocytes, ultimately aggravating psoriasis. Our findings uncover a role for SHP2 in NET release and subsequent cell death known as NETosis in the progression of psoriasis and suggest that SHP2 may be a promising therapeutic target for psoriasis.

Substances (2)

Materials
Procduct Name CAS Molecular Formula Supplier Price
AX-15836 2035509-96-5 C32H40N8O5S 51 suppliers Inquiry
AX-15836 2035509-96-5 C32H40N8O5S 51 suppliers Inquiry

Similar articles

IF:3.3

Curcumin ameliorates astrocyte inflammation through AXL in cuprizone-induced mice

Toxicology and applied pharmacology Wenjing Zhang, Mengjiao Sun,etc Published: 23 November 2024
IF:0

L-Tyrosine

Definitions Published: 7 February 2020
马山县| 哈巴河县| 信宜市| 河北省| 武功县| 昌都县| 东辽县| 富顺县| 新和县| 常德市| 永昌县| 灌云县| 道孚县| 古蔺县| 望城县| 寿宁县| 余姚市| 凤城市| 赣榆县| 应用必备| 伊金霍洛旗| 香港| 庆阳市| 留坝县| 商洛市| 吴堡县| 建宁县| 长岛县| 临江市| 修文县| 杭锦后旗| 德清县| 泸水县| 简阳市| 遂昌县| 云阳县| 舟山市| 浏阳市| 临潭县| 应用必备| 宿州市|