一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Bioactive Materials >>article
Bioactive Materials

Bioactive Materials

IF: 18
Download PDF

Dexamethasone-loaded ROS-responsive poly(thioketal) nanoparticles suppress inflammation and oxidative stress of acute lung injury

Published:1 August 2022 DOI:
Zihe Zhai , Wei Ouyang , Yuejun Yao , Yuqi Zhang , Haolan Zhang , Feng Xu , Changyou Gao

Abstract

Acute lung injury (ALI) is associated with excessive inflammatory response, leading to acute respiratory distress syndrome (ARDS) without timely treatment. A fewer effective drugs are available currently to treat the ALI/ARDS. Herein, a therapeutic nanoplatform with reactive oxygen species (ROS)-responsiveness was developed for the regulation of inflammation. Dexamethasone acetate (Dex) was encapsulated into poly(thioketal) polymers to form polymeric nanoparticles (NPs) (PTKNPs@Dex). The NPs were composed of poly(1,4-phenyleneacetonedimethylene thioketal) (PPADT) and polythioketal urethane (PTKU), in which the thioketal bonds could be cleaved by the high level of ROS at the ALI site. The PTKNPs@Dex could accumulate in the pulmonary inflammatory sites and release the encapsulated payloads rapidly, leading to the decreased ROS level, less generation of pro-inflammatory cytokines, and reduced lung injury and mortality of mice. RNA sequencing (RNA-seq) analysis showed that the therapeutic efficacy of the NPs was associated with the modulation of many immune and inflammation-linked pathways. These findings provide a newly developed nanoplatform for the efficient treatment of ALI/ARDS.

Similar articles

IF:0.4

Dihydromyricetin Prevents Inflammation and Oxidative Stress in Human Osteoarthritis Chondrocytes

Current Topics in Nutraceutical Research P. Yao,?Jinwei Ai,etc Published: 1 September 2021
IF:3.7

Curcumin and Especially Tetrahydrocurcumin Ameliorate Oxidative Stress-Induced Renal Injury in Mice

Journal of Nutrition Okada Kunihiko , Wangpoengtrakul Chantima ,etc Published: 1 August 2001
文化| 兰西县| 河北区| 若尔盖县| 光山县| 颍上县| 慈利县| 惠来县| 冷水江市| 怀远县| 堆龙德庆县| 临漳县| 桂平市| 临湘市| 克拉玛依市| 大兴区| 巨鹿县| 茂名市| 墨玉县| 婺源县| 两当县| 漠河县| 敖汉旗| 德令哈市| 蛟河市| 鲜城| 兰西县| 榆社县| 天水市| 永吉县| 靖远县| 中山市| 武威市| 儋州市| 邵武市| 临海市| 柘荣县| 盐池县| 三原县| 呼伦贝尔市| 南漳县|