一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> European Polymer Journal >>article
European Polymer Journal

European Polymer Journal

IF: 5.8
Download PDF

Gelatin-based NIR and reduction-responsive injectable hydrogels cross-linked through IEDDA click chemistry for drug delivery application

Published:13 June 2023 DOI: 10.1016/j.eurpolymj.2023.112019
Ali Rizwan , Muhammad Gulfam , Sung-Han Jo , Jeong-Woo Seo , Israr Ali , Trung Thang Vu , Soo-Bin Joo , Sang-Hyug Park , Kwon Taek Lim

Abstract

NIR and reduction-responsive gelatin hydrogels were designed for anti-tumor drug delivery application. Gelatin was functionalized with norbornene (Gel-Nb), followed by covalently cross-linking with a tetrazine (Tz)-based cross-linker (DSe-DPEG-DTz) possessing a redox-cleavable diselenide moiety. The resulting hydrogels were highly porous thanks to the N2 gas produced during the inverse electron demand Diels Alder ‘‘click reaction’’ between Nb and Tz. The hydrogels exhibited enhanced drug loading efficiency (≈ 94%) and excellent swelling ratios. The hydrogel prepared from the Nb:Tz mol. ratio of 10:10 (GHG-C) showed a storage modulus of 1100?Pa with an elastic rheological property. The doxorubicin (DOX)-loaded hydrogels (AR1) released minimal amounts (26%) of DOX at a physiological condition (PBS, pH 7.4). On the contrary, a fast release of DOX was observed in a reducing environment, where?>?95% of DOX was released from AR3 after 48?h. The DOX and indocyanine green (ICG) co-loaded hydrogels (AR6) showed a burst release of DOX (>60% after 12?h) upon NIR irradiation, followed by a sustained release of the drug. The combined stimuli of GSH and NIR showed ≈ 85% in half of the total time. Gel-Nb, the cross-linker, and GHG-C were essentially non-toxic to the tested cell lines. Furthermore, AR3 and AR6 restricted the metabolic activities of BT-20 cells after treatment with GSH and NIR irradiation, respectively.

Substances (8)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Doxorubicin hydrochloride 25316-40-9 C27H29NO11.ClH 956 suppliers $15.00-$7060.00
Doxorubicin hydrochloride 25316-40-9 C27H29NO11.ClH 956 suppliers $15.00-$7060.00
Doxorubicin hydrochloride 25316-40-9 C27H29NO11.ClH 956 suppliers $15.00-$7060.00
Doxorubicin hydrochloride 25316-40-9 C27H29NO11.ClH 956 suppliers $15.00-$7060.00
Doxorubicin hydrochloride 25316-40-9 - Inquiry
Doxorubicin hydrochloride 25316-40-9 - Inquiry
Doxorubicin HCl 25316-40-9 - Inquiry
Doxorubicin HCl 25316-40-9 - Inquiry

Similar articles

IF:10.7

A novel pH-responsive hydrogel based on carboxymethyl cellulose/2-hydroxyethyl acrylate for transdermal delivery of naringenin

Carbohydrate Polymers So Hyun Park, Hyuk Soo Shin,etc Published: 15 November 2018
IF:5

Albumin nanostructures as advanced drug delivery systems.

Expert Opinion on Drug Delivery Mahdi Karimi,?Sajad Bahrami,etc Published: 1 November 2016
IF:5

Fatigue-resistant hydrogels controlled by sulfanilic acid cross-linker at molecular level

Polymer Testing Zhenming Qi, Xiaosai Hu,etc Published: 1 February 2022
武邑县| 虹口区| 哈尔滨市| 沾化县| 阳江市| 易门县| 娄烦县| 石景山区| 定安县| 清涧县| 肇州县| 灵丘县| 麻江县| 三明市| 南汇区| 郁南县| 惠水县| 双峰县| 临城县| 封开县| 安图县| 沙雅县| 富锦市| 临桂县| 文化| 溆浦县| 永登县| 石台县| 大荔县| 仙居县| 大连市| 海兴县| 桐柏县| 永宁县| 古蔺县| 渝中区| 曲周县| 楚雄市| 海南省| 宜兴市| 固原市|