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Nutrients

Nutrients

IF: 4.8
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Serine Metabolism in Health and Disease and as a Conditionally Essential Amino Acid

Published:1 May 2022 DOI: 10.3390/nu14091987
M. Hole?ek

Abstract

L-serine plays an essential role in a broad range of cellular functions including protein synthesis, neurotransmission, and folate and methionine cycles and synthesis of sphingolipids, phospholipids, and sulphur containing amino acids. A hydroxyl side-chain of L-serine contributes to polarity of proteins, and serves as a primary site for binding a phosphate group to regulate protein function. D-serine, its D-isoform, has a unique role. Recent studies indicate increased requirements for L-serine and its potential therapeutic use in some diseases. L-serine deficiency is associated with impaired function of the nervous system, primarily due to abnormal metabolism of phospholipids and sphingolipids, particularly increased synthesis of deoxysphingolipids. Therapeutic benefits of L-serine have been reported in primary disorders of serine metabolism, diabetic neuropathy, hyperhomocysteinemia, and amyotrophic lateral sclerosis. Use of L-serine and its metabolic products, specifically D-serine and phosphatidylserine, has been investigated for the therapy of renal diseases, central nervous system injury, and in a wide range of neurological and psychiatric disorders. It is concluded that there are disorders in which humans cannot synthesize L-serine in sufficient quantities, that L-serine is effective in therapy of disorders associated with its deficiency, and that L-serine should be classified as a “conditionally essential” amino acid.

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L-Serine 56-45-1 C3H7NO3 1071 suppliers $5.00-$9080.00
D-Serine 312-84-5 C3H7NO3 784 suppliers $5.00-$1327.20
L-ALPHA-PHOSPHATIDYL-L-SERINE C42H82NO10P 41 suppliers $66.50-$1560.00
PHOSPHOLIPIDS 40 suppliers $1440.00-$1440.00
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