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Drug Design, Development and Therapy

Drug Design, Development and Therapy

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Luteolin Attenuates Atherosclerosis Via Modulating Signal Transducer And Activator Of Transcription 3-Mediated Inflammatory Response

Published:1 November 2019 DOI: 10.2147/DDDT.S207185
Xiaoji Ding,?Lulu Zheng,?Bo Yang,?Xiaodong Wang,?Y. Ying

Abstract

Background Inflammatory factors play a crucial role throughout the development and progression of atherosclerosis, which has been considered as a chronic vascular inflammatory disease. Luteolin, a natural flavonoid which exists in many natural medicinal materials, has anti-inflammatory, anti-fibrotic and other pharmacological effects. Recently, the protective effects of luteolin on the cardiovascular disease have been reported. However, there is a paucity of studies on anti-atherosclerosis. Therefore, the anti-atherosclerosis potential of luteolin remains to be elucidated. Method ApoE-/- mice were fed with a high-fat diet to induce atherosclerosis in an animal model, where they were treated with oral administration of luteolin for 12 weeks. Primary mouse peritoneal macrophages challenged with oxidized low-density lipoprotein (oxLDL) were used for in vitro mechanistic study. The effectiveness of luteolin in the ApoE-/- mouse model of atherosclerosis was estimated in the aortic sinus and enface, and the underlying mechanisms were explored by molecular modeling study and siRNA-induced gene silencing. Results Our results showed that luteolin remarkably attenuated atherosclerosis in high-fat diet-induced ApoE-/- mouse via alleviating inflammation. We further found that luteolin decreased oxLDL-induced inflammation by inhibiting signal transducer and activator of transcription 3 (STAT3) in vitro, respectively. Further molecular modeling analysis indicated that luteolin interacted with STAT3 primarily through hydrogen bond interaction. Conclusion Luteolin could be a promising candidate molecule for atherosclerosis, and STAT3 may be a potential therapeutic target that could prevent the development of atherosclerosis.

Substances (12)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Luteolin 491-70-3 C15H10O6 763 suppliers $5.00-$1605.00
Luteolin 491-70-3 C15H10O6 763 suppliers $5.00-$1605.00
Luteolin 491-70-3 C15H10O6 763 suppliers $5.00-$1605.00
Luteolin 491-70-3 C15H10O6 763 suppliers $5.00-$1605.00
Luteolin 491-70-3 - Inquiry
Luteolin 491-70-3 - Inquiry
Luteolin 491-70-3 - Inquiry
Luteolin 491-70-3 - Inquiry
Luteolin 491-70-3 - Inquiry
Luteolin 491-70-3 - Inquiry

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