一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of Biological Rhythms >>article
Journal of Biological Rhythms

Journal of Biological Rhythms

IF: 2.1
Download PDF

The Molecular Circadian Clock Is a Target of Anti-cancer Translation Inhibitors

Published:1 February 2024 DOI: 10.1177/07487304231202561 PMID: 37872767
Alexandre Berthier,?Céline Gheeraert,?Manuel Johanns,?Manjula Vinod,?Bart Staels,?Jér?me Eeckhoute,?Philippe Lefebvre

Abstract

Circadian-paced biological processes are key to physiology and required for metabolic, immunologic, and cardiovascular homeostasis. Core circadian clock components are transcription factors whose half-life is precisely regulated, thereby controlling the intrinsic cellular circadian clock. Genetic disruption of molecular clock components generally leads to marked pathological events phenotypically affecting behavior and multiple aspects of physiology. Using a transcriptional signature similarity approach, we identified anti-cancer protein synthesis inhibitors as potent modulators of the cardiomyocyte molecular clock. Eukaryotic protein translation inhibitors, ranging from translation initiation (rocaglates, 4-EGI1, etc.) to ribosomal elongation inhibitors (homoharringtonine, puromycin, etc.), were found to potently ablate protein abundance of REV-ERBα, a repressive nuclear receptor and component of the molecular clock. These inhibitory effects were observed both in vitro and in vivo and could be extended to PER2, another component of the molecular clock. Taken together, our observations suggest that the activity spectrum of protein synthesis inhibitors, whose clinical use is contemplated not only in cancers but also in viral infections, must be extended to circadian rhythm disruption, with potential beneficial or iatrogenic effects upon acute or prolonged administration.

Substances (19)

Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
Clofarabine 123318-82-1 C10H11ClFN5O3 469 suppliers $7.00-$1732.50
Clofarabine 123318-82-1 C10H11ClFN5O3 469 suppliers $7.00-$1732.50
Clofarabine 123318-82-1 C10H11ClFN5O3 469 suppliers $7.00-$1732.50
Clofarabine 123318-82-1 C10H11ClFN5O3 469 suppliers $7.00-$1732.50
SALUBRINAL 405060-95-9 C21H17Cl3N4OS 172 suppliers $11.00-$3443.00
SALUBRINAL 405060-95-9 C21H17Cl3N4OS 172 suppliers $11.00-$3443.00
SALUBRINAL 405060-95-9 C21H17Cl3N4OS 172 suppliers $11.00-$3443.00
SALUBRINAL 405060-95-9 C21H17Cl3N4OS 172 suppliers $11.00-$3443.00
4EGI-1 315706-13-9 C18H12Cl2N4O4S 99 suppliers $14.00-$3425.00
4EGI-1 315706-13-9 C18H12Cl2N4O4S 99 suppliers $14.00-$3425.00

Similar articles

IF:6.2

344-OR: The MOTS-c/CK2 Pathway Is a Novel Molecular Target for Type 2 Diabetes in East Asians

Diabetes HIROSHI KUMAGAI, SU JEONG KIM,etc Published: 19 July 2024
IF:5.3

A preliminary study: the anti-proliferation effect of salidroside on different human cancer cell lines.

Cell Biology and Toxicology Xiaolan Hu, Shuxin Lin,etc Published: 1 December 2010
IF:4.2

Cisplatin in cancer therapy: Molecular mechanisms of action

European journal of pharmacology Shaloam Dasari, Paul Bernard Tchounwou,etc Published: 5 October 2014
敖汉旗| 新巴尔虎右旗| 台安县| 苏尼特右旗| 峨眉山市| 钟祥市| 常宁市| 香格里拉县| 紫阳县| 东平县| 雷州市| 夹江县| 岗巴县| 阳泉市| 体育| 乌拉特后旗| 晋宁县| 阿瓦提县| 社旗县| 团风县| 肥城市| 绥棱县| 台湾省| 青神县| 孙吴县| 镶黄旗| 裕民县| 改则县| 宁化县| 托克托县| 交城县| 毕节市| 巩义市| 宁陕县| 灌南县| 延川县| 新乡县| 韩城市| 徐汇区| 文昌市| 潼关县|