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Microvascular research

Microvascular research

IF: 2.7
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Cdc42 regulates LPS-induced proliferation of primary pulmonary microvascular endothelial cells via ERK pathway.

Published:1 January 2017 DOI: 10.1016/j.mvr.2016.10.001
Jiawen Lv , Junchao Zeng , Wen Zhao , Yuanxiong Cheng , Lin Zhang , Shaoxi Cai , Guodong Hu , Yinghua Chen

Abstract

Background

After stimulation due to injury, cell division cycle protein 42 (Cdc42) restores and enhances barrier functions by strengthening intercellular adherens junctions; however, its influence on cell proliferation after injury remains unknown.

Objective

In this study, we sought to investigate the effect of stimulation using small doses of lipopolysaccharide (LPS) on the proliferation of pulmonary microvascular endothelial cells (PMVECs).

Methods

We stimulated PMVECs with different doses of LPS and evaluated the effects on cell proliferation. We also constructed a primary gene-knockout cell line lacking Cdc42 to verify the role of Cdc42 in regulating the proliferation of PMVECs that were stimulated using LPS and to explore related signaling pathways.

Results

Stimulating PMVECs with small doses of LPS increased proliferation. Cdc42 is involved in regulating this process, which was mediated by the extracellular regulated protein kinase (ERK) pathway.

Conclusions

Cdc42 plays a role in regulating the proliferation of PMVECs stimulated with small doses of LPS, and this regulation involves the ERK pathway.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine 865362-74-9 C18H13N7 116 suppliers $26.00-$3282.70
5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine 865362-74-9 C18H13N7 116 suppliers $26.00-$3282.70
5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine 865362-74-9 C18H13N7 116 suppliers $26.00-$3282.70
5-(2-Phenyl-pyrazolo[1,5-a]pyridin-3-yl)-1H-pyrazolo[3,4-c]pyridazin-3-ylamine 865362-74-9 C18H13N7 116 suppliers $26.00-$3282.70

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