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Viruses-Basel

Viruses-Basel

IF: 3.5
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RSL3 Inhibits Porcine Epidemic Diarrhea Virus Replication by Activating Ferroptosis

Published:12 October 2023 DOI: 10.3390/v15102080 PMID: 37896857
Yingguang Li, Yuwei Bao, Yan Li, Xiaoxiao Duan, Shaoming Dong, Jiaxu Lin, Xiaoyun Chang, Yue Tan, Hongliang Zhang, Hu Shan

Abstract

Porcine epidemic diarrhea virus (PEDV) is a highly contagious coronavirus that induces diarrhea and death in neonatal piglets, resulting in substantial economic losses to the global swine industry. The mechanisms of PEDV infection and the roles of host factors are still under exploration. In this study, we used the ferroptosis pathway downstream target activator (1S,3R)-RSL3 compound as a starting point, combined with the interactions of N-acetylcysteine and deferoxamine, to elucidate the effects of a series of compounds on PEDV proliferation. We also established glutathione peroxidase 4 (GPX4) gene overexpression to further elucidate the relationship between the ferroptosis pathway and PEDV. (1S,3R)-RSL3 inhibited PEDV replication in Vero cells, while N-acetylcysteine and deferoxamine promoted its proliferation. In addition, (1S,3R)-RSL3 mainly affected the replication stage of PEDV. Overexpression of GPX4 promoted PEDV proliferation, indicating that the ferroptosis pathway could influence PEDV replication in Vero cells. This study focused on the mechanism of (1S,3R)-RSL3 inhibition on PEDV, laying the foundation for exploring the pathogenic mechanisms of PEDV and drug development.

Substances (20)

Materials
Procduct Name CAS Molecular Formula Supplier Price
N-Acetyl-L-cysteine 616-91-1 C5H9NO3S 1339 suppliers $5.00-$3143.10
N-Acetyl-L-cysteine 616-91-1 C5H9NO3S 1339 suppliers $5.00-$3143.10
N-Acetyl-L-cysteine 616-91-1 C5H9NO3S 1339 suppliers $5.00-$3143.10
N-Acetyl-L-cysteine 616-91-1 C5H9NO3S 1339 suppliers $5.00-$3143.10
DEFEROXAMINE MESYLATE 138-14-7 C26H52N6O11S 293 suppliers $10.00-$4712.50
DEFEROXAMINE MESYLATE 138-14-7 C26H52N6O11S 293 suppliers $10.00-$4712.50
DEFEROXAMINE MESYLATE 138-14-7 C26H52N6O11S 293 suppliers $10.00-$4712.50
DEFEROXAMINE MESYLATE 138-14-7 C26H52N6O11S 293 suppliers $10.00-$4712.50
RSL3 1219810-16-8 C23H21ClN2O5 218 suppliers $13.00-$2492.00
RSL3 1219810-16-8 C23H21ClN2O5 218 suppliers $13.00-$2492.00

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