一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Definitions >>article

Definitions

Download PDF

Monomethyl Auristatin E

Published:2 February 2020 DOI: 10.32388/hcrd1w

Abstract

A dolastatin-10 peptide derivative with potent antimitotic activity and potential antineoplastic activity as part of an antibody-drug conjugate (ADC). Monomethyl auristatin E (MMAE) binds to tubulin, blocks tubulin polymerization, and inhibits microtubule formation, which results in both disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. T o minimize toxicity and maximize efficacy, MMAE is conjugated, via a cleavable peptide linker, to a monoclonal antibody that specifically targets a patient's tumor. T he linker is stable in the extracellular milieu but is readily cleaved to release MMAE following binding and internalization of the ADC by the target cells. Qeios · Definition, February 2, 2020

Substances (4)

Related products
Procduct Name CAS Molecular Formula Supplier Price
MonoMethyl auristatin E 474645-27-7 C39H67N5O7 336 suppliers $10.00-$3772.00
dolastatin 10 110417-88-4 C42H68N6O6S 111 suppliers Inquiry
Auristatin E 160800-57-7 C40H69N5O7 83 suppliers Inquiry
Monomethyl auristatin E (MMAE) hydrochloride 1359995-63-3 C39H68ClN5O7 2 suppliers Inquiry

Similar articles

IF:4.6

Peripheral neuropathy associated with monomethyl auristatin E-based antibody-drug conjugates

iScience Zhiwen Fu , Chen Gao ,etc Published: 20 October 2023
IF:2.7

Acute oral toxicity of ethylene glycol monomethyl ether and diethylene glycol monomethyl ether.

Bulletin of Environmental Contamination and Toxicology T Kawamoto, K Matsuno,etc Published: 1 April 1990
IF:3.3

Diethylene glycol monomethyl ether, ethylene glycol monomethyl ether and the metabolite, 2-methoxyacetic acid affect in vitro chondrogenesis

Reproductive toxicology Emily Hanson Scofield , W. Matthew Henderson ,etc Published: 1 November 2006

Latest Papers

Nickel Sulfate

Published: 8 February 2020

L-Tyrosine

Published: 7 February 2020
永宁县| 威海市| 固原市| 博客| 常山县| 林芝县| 竹北市| 兴仁县| 香港 | 肇源县| 乐平市| 礼泉县| 卢氏县| 哈巴河县| 罗平县| 岑溪市| 岑溪市| 璧山县| 昭苏县| 新邵县| 嫩江县| 象州县| 信阳市| 托克逊县| 仙桃市| 禹州市| 五原县| 西平县| 长治县| 翁源县| 深州市| 义马市| 庆元县| 罗田县| 广饶县| 四川省| 濉溪县| 剑川县| 嵊泗县| 陇西县| 玉门市|