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Monomethyl Auristatin E

Published:2 February 2020 DOI: 10.32388/hcrd1w

Abstract

A dolastatin-10 peptide derivative with potent antimitotic activity and potential antineoplastic activity as part of an antibody-drug conjugate (ADC). Monomethyl auristatin E (MMAE) binds to tubulin, blocks tubulin polymerization, and inhibits microtubule formation, which results in both disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. T o minimize toxicity and maximize efficacy, MMAE is conjugated, via a cleavable peptide linker, to a monoclonal antibody that specifically targets a patient's tumor. T he linker is stable in the extracellular milieu but is readily cleaved to release MMAE following binding and internalization of the ADC by the target cells. Qeios · Definition, February 2, 2020

Substances (4)

Related products
Procduct Name CAS Molecular Formula Supplier Price
MonoMethyl auristatin E 474645-27-7 C39H67N5O7 336 suppliers $10.00-$3772.00
dolastatin 10 110417-88-4 C42H68N6O6S 111 suppliers Inquiry
Auristatin E 160800-57-7 C40H69N5O7 83 suppliers Inquiry
Monomethyl auristatin E (MMAE) hydrochloride 1359995-63-3 C39H68ClN5O7 2 suppliers Inquiry

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