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Synthesis-Stuttgart

Synthesis-Stuttgart

IF: 2.2
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A New and Practical Synthesis of Vortioxetine Hydrobromide

Published:13 April 2015 DOI: 10.1055/S-0034-1380505
Yongjun Mao,?Luobin Jiang,?T. Chen,?H. He,?Gang Liu,?Han Wang

Abstract

Abstract A new and improved synthetic route to vortioxetine hydrobromide is established on a hectogram scale through three simple steps in 63% yield and with 99% purity (HPLC). The key step is the cyclization of the piperazine ring in the final step. Purification methods for the intermediates involved in the route are given.

Substances (2)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Piperazine 110-85-0 C4H10N2 647 suppliers $5.00-$3250.00
Vortioxetine hydrobromide 960203-27-4 C18H23BrN2S 418 suppliers $18.00-$2350.00

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