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Synthesis-Stuttgart

Synthesis-Stuttgart

IF: 2.2
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A New and Practical Synthesis of Vortioxetine Hydrobromide

Published:13 April 2015 DOI: 10.1055/S-0034-1380505
Yongjun Mao,?Luobin Jiang,?T. Chen,?H. He,?Gang Liu,?Han Wang

Abstract

Abstract A new and improved synthetic route to vortioxetine hydrobromide is established on a hectogram scale through three simple steps in 63% yield and with 99% purity (HPLC). The key step is the cyclization of the piperazine ring in the final step. Purification methods for the intermediates involved in the route are given.

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Related products
Procduct Name CAS Molecular Formula Supplier Price
Piperazine 110-85-0 C4H10N2 647 suppliers $5.00-$3250.00
Vortioxetine hydrobromide 960203-27-4 C18H23BrN2S 418 suppliers $18.00-$2350.00

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