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Journal of Natural Products

Journal of Natural Products

IF: 3.6
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Dolabrane-Type Diterpenoids with Immunosuppressive Activity from Koilodepas hainanense

Published:9 June 2022 DOI: 10.1021/acs.jnatprod.2c00204
Yu Ren, Xiao Tong, Ye Zhao, Shi-Jun He, Yao-Yue Fan* and Jian-Min Yue*, 

Abstract

Thirteen new dolabrane-type diterpenoids, koilodenoids A–M (113), including a chlorinated congener (2), along with six known analogues, were isolated from Koilodepas hainanense. The structures were determined by analysis of spectroscopic data, ECD spectra, and X-ray crystallographic studies. The absolute configuration of C-15 in the 15,16-diol unit of compounds 4 and 5 was established by using the dimolybdenum tetraacetate [Mo2(AcO)4]-induced ECD method. Compounds 4, 7, 16, 17, and 19 showed moderate to significant immunosuppressive activities against the proliferation of T and B lymphocytes in vitro, with compound 16 being the most potent (IC50 0.86 and 0.29 μM, respectively).

Substances (6)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Cyclosporin A 59865-13-3 C62H111N11O12 783 suppliers $10.00-$2759.00
Cyclosporin A 59865-13-3 C62H111N11O12 783 suppliers $10.00-$2759.00
Cyclosporin A 59865-13-3 C62H111N11O12 783 suppliers $10.00-$2759.00
Cyclosporin A 59865-13-3 C62H111N11O12 783 suppliers $10.00-$2759.00
Cyclosporin A 59865-13-3 - Inquiry
Cyclosporin A 59865-13-3 - Inquiry

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