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Materials Today Bio

Materials Today Bio

IF: 8.7
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ISX9 loaded thermoresponsive nanoparticles for hair follicle regrowth

Published:3 November 2023 DOI: 10.1016/j.mtbio.2023.100849
Sapna Sayed , Mehdihasan Shekh , Jiaxing Song , Qi Sun , Han Dai , Vivian Weiwen Xue , Shanshan Liu , Bing Du , Guangqian Zhou , Florian J. Stadler , Guangming Zhu , Desheng Lu

Abstract

There is a high demand for an optimal drug delivery system to treat androgenetic alopecia. Topical application of ISX9, which is a neurogenesis inducer, has been found to stimulate hair follicle (HF) regrowth by upregulating the Wnt/β-catenin signaling pathway, an essential pathway involved in initiating HF growth and development. In the present study, a temperature-sensitive, biopolymer-based, biocompatible, and eco-friendly drug-delivery system was synthesized. This system comprised chitosan-grafted poly(glycidyl methacrylate-co-N-isopropyl acrylamide) (Poly(GMA-co-NIPAAm)@CS-PGNCS) as the shell component and PF127 as the core polymer. The hydrophobic nature of the PF127 block copolymer efficiently dissolved the partially water-soluble drug, ISX9, and the thermos-responsive shell polymer effectively released the drug at a definite skin temperature. The optimized spherical nanoparticles demonstrated the lowest critical solution temperature (LCST) at 32?±?2?°C with a diameter of 100–250?nm, which delivered encapsulated ISX9 with greater precision than topical ISX9. In a series of in vivo experiments, we demonstrated that ISX9-coated TBNPs upregulated the expression of β-catenin, active β-catenin, Wnt target genes, stemness marker genes, proliferating cell nuclear antigen, HF stem cell markers, and HF markers including VEGF, TGF, and IGF-1 more effectively than topical ISX9. These results suggest that TBNPs could be employed as a platform for effective transdermal delivery of various hydrophobic drugs.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
ISX 9 832115-62-5 C11H10N2O2S 154 suppliers $10.00-$3330.00
ISX 9 832115-62-5 C11H10N2O2S 154 suppliers $10.00-$3330.00
ISX 9 832115-62-5 C11H10N2O2S 154 suppliers $10.00-$3330.00
ISX 9 832115-62-5 C11H10N2O2S 154 suppliers $10.00-$3330.00

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