一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of Medicinal Chemistry >>article
Journal of Medicinal Chemistry

Journal of Medicinal Chemistry

IF: 6.8
Download PDF

End-to-End Automated Synthesis of C(sp3)-Enriched Drug-like Molecules via Negishi Coupling and Novel, Automated Liquid–Liquid Extraction

Published:15 December 2022 DOI: 10.1021/acs.jmedchem.2c01646
Irini Abdiaj*, Santiago Ca?ellas, Alejandro Dieguez, Maria Lourdes Linares, Brenda Pijper, Alberto Fontana, Raquel Rodriguez, Andres Trabanco, Eduardo Palao and Jesus Alcázar*, 

Abstract

Herein, we report an end-to-end process including synthesis, work-up, purification, and post-purification with minimal human intervention using Negishi coupling as a key transformation to increase Fsp3 in bioactive molecules. The main advantages of this protocol are twofold. First, the automated sequential generation of organozinc reagents from readily available alkyl halides offers a large diversity of alkyl groups to functionalize (hetero)aryl halide scaffolds via Pd-catalyzed Negishi coupling in continuous flow. Second, a fully automated liquid–liquid extraction has been developed and successfully applied for unattended operations. The workflow was completed with mass-triggered preparative high-performance liquid chromatography HPLC, providing an efficient production line of compounds with enriched sp3 character and better drug-like properties. The modular nature allows a smooth adaptation to a wide variety of synthetic methods and protocols and makes it applicable to any medchem laboratory.

Substances (1)

Related products
Procduct Name CAS Molecular Formula Supplier Price
Negishi Coupling in a Box 2 suppliers $107.00-$107.00

Similar articles

IF:4.7

Polyisobutylenes with Controlled Molecular Weight and Chain-End Structure: Synthesis and Actual Applications.

Polymers Ilya E Nifant'ev, Sofia A Korchagina,etc Published: 15 August 2023
IF:9.3

Electrocatalytic C–N coupling for urea synthesis: a critical review

Green Chemistry Chuanju Yang , Zhe Li ,etc Published: 7 May 2024
IF:1.9

Synthesis of Pyrimidine Derivatives Catalyzed by Nanomagnetic Pyridinium-Tribromide Ionic Liquid

ChemistrySelect Azin Kharazmi, Prof. Ramin Ghorbani-Vaghei,etc Published: 27 January 2020
安岳县| 桂东县| 蒲江县| 英吉沙县| 沙洋县| 于都县| 疏附县| 涞水县| 襄城县| 武山县| 天长市| 英山县| 武威市| 嘉峪关市| 蓝山县| 象山县| 东莞市| 石家庄市| 新竹市| 仁化县| 武宣县| 合山市| 辽源市| 清水河县| 永定县| 丹阳市| 东宁县| 绍兴市| 海兴县| 教育| 泗阳县| 巧家县| 望谟县| 广丰县| 措勤县| 冷水江市| 吐鲁番市| 嵊州市| 阳谷县| 巨鹿县| 莒南县|