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Journal of Nanobiotechnology

Journal of Nanobiotechnology

IF: 10.6
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Fibronectin-targeting and metalloproteinase-activatable smart imaging probe for fluorescence imaging and image-guided surgery of breast cancer

Published:28 March 2023 DOI: 10.1186/s12951-023-01868-5 PMID: 36978072
Zhongquan Cheng, Yushen Jin, Jiaqian Li, Guangyuan Shi, Leyi Yu, Bing Shao, Jie Tian, Yang Du, Zhu Yuan

Abstract

Residual lesions in the tumor bed have been a challenge for conventional white-light breast-conserving surgery. Meanwhile, lung micro-metastasis also requires improved detection methods. Intraoperative accurate identification and elimination of microscopic cancer can improve surgery prognosis. In this study, a smart fibronectin-targeting and metalloproteinase-activatable imaging probe CREKA-GK8-QC is developed. CREKA-GK8-QC possesses an average diameter of 21.7?±?2.5?nm, excellent MMP-9 protein responsiveness and no obvious cytotoxicity. In vivo experiments demonstrate that NIR-I fluorescence imaging of CREKA-GK8-QC precisely detects orthotopic breast cancer and micro-metastatic lesions (nearly 1?mm) of lungs with excellent imaging contrast ratio and spatial resolution. More notably, fluorescence image-guided surgery facilitates complete resection and avoids residual lesions in the tumor bed, improving survival outcomes. We envision that our newly developed imaging probe shows superior capacity for specific and sensitive targeted imaging, as well as providing guidance for accurate surgical resection of breast cancer.

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Materials
Procduct Name CAS Molecular Formula Supplier Price
Ilomastat 142880-36-2 C20H28N4O4 174 suppliers $19.00-$5661.00
Ilomastat 142880-36-2 C20H28N4O4 174 suppliers $19.00-$5661.00
Ilomastat 142880-36-2 C20H28N4O4 174 suppliers $19.00-$5661.00
Ilomastat 142880-36-2 C20H28N4O4 174 suppliers $19.00-$5661.00

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