一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Science Advances >>article
Science Advances

Science Advances

IF: 11.7
Download PDF

Structural basis for motilin and erythromycin recognition by motilin receptor

Published:15 March 2023 DOI: 10.1126/sciadv.ade9020 PMID: 36921049
Chongzhao?You, Yumu?Zhang, Youwei?Xu, Peiyu?Xu, Zhen?Li, Huadong?Li, Sijie?Huang, Zecai?Chen, Jingru?Li, H. Eric?Xu, Yi?Jiang

Abstract

Motilin is an endogenous peptide hormone almost exclusively expressed in the human gastrointestinal (GI) tract. It activates the motilin receptor (MTLR), a class A G protein–coupled receptor (GPCR), and stimulates GI motility. To our knowledge, MTLR is the first GPCR reported to be activated by macrolide antibiotics, such as erythromycin. It has attracted extensive attention as a potential drug target for GI disorders. We report two structures of Gq-coupled human MTLR bound to motilin and erythromycin. Our structures reveal the recognition mechanism of both ligands and explain the specificity of motilin and ghrelin, a related gut peptide hormone, for their respective receptors. These structures also provide the basis for understanding the different recognition modes of erythromycin by MTLR and ribosome. These findings provide a framework for understanding the physiological regulation of MTLR and guiding drug design targeting MTLR for the treatment of GI motility disorders.

Substances (1)

Related products
Procduct Name CAS Molecular Formula Supplier Price
1,5-HEXADIENE 592-42-7 C6H10 198 suppliers $30.00-$314.65

Similar articles

IF:4.3

Discovery of brevijanazines from Aspergillus brevijanus reveals the molecular basis for p-nitrobenzoic acid in fungi?

Chemical Communications Hang Li , Paul M. Mirzayans ,etc Published: 1 January 2022
IF:0

Brain histamine H1 receptor occupancy measured by PET after oral administration of desloratadine and loratadine

Proceedings for Annual Meeting of The Japanese Pharmacological Society Tadaho Nakamura,?K. Hiraoka,etc Published: 1 January 2019
明星| 武陟县| 永福县| 保德县| 卫辉市| 海城市| 游戏| 玉门市| 从化市| 瑞昌市| 温泉县| 夹江县| 博兴县| 辽阳县| 灌阳县| 革吉县| 彰武县| 萍乡市| 淮滨县| 吉安市| 辰溪县| 柳江县| 巴东县| 宾阳县| 冷水江市| 延川县| 德兴市| 定日县| 洛川县| 麻栗坡县| 顺平县| 固镇县| 淮安市| 海兴县| 旬阳县| 南宁市| 深州市| 温泉县| 湘潭市| 城固县| 青田县|