一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Journal of affective disorders >>article
Journal of affective disorders

Journal of affective disorders

IF: 4.9
Download PDF

The antidepressant-like effects of escitalopram in mice require salt-inducible kinase 1 and CREB-regulated transcription co-activator 1 in the paraventricular nucleus of the hypothalamus

Published:1 October 2023 DOI: 10.1016/j.jad.2023.05.085 PMID: 37257779
Tian-Shun Shi , Wei-Yu Li , Yan-Mei Chen , Jie Huang , Wei Guan , Da-Wei Xu , Bo Jiang

Abstract

Background

The salt-inducible kinase 1 (SIK1)-CREB-regulated transcription co-activator 1 (CRTC1) system in the paraventricular nucleus (PVN) of the hypothalamus has been demonstrated to participate in not only depression neurobiology but also the antidepressant mechanisms of fluoxetine, paroxetine, venlafaxine, and duloxetine. Like fluoxetine and paroxetine, escitalopram is also a well-known selective serotonin (5-HT) reuptake inhibitor (SSRI). However, recently it has been found that escitalopram can modulate a lot of targets other than the 5-HT system. Here, we speculate that escitalopram produces effects on the SIK1-CRTC1 system in the PVN.

Methods

Two mice models of depression (chronic social defeat stress (CSDS) and chronic unpredictable mild stress (CUMS)), various behavioral tests, enzyme linked immunosorbent assay (ELISA), western blotting, co-immunoprecipitation (Co-IP), quantitative real-time reverse transcription PCR (qRT-PCR), immunofluorescence, and adeno-associated virus (AAV)-mediated gene transfer were used together in the present study.

Results

It was found that escitalopram administration not only significantly prevented the hyperactivity of the hypothalamic-pituitary-adrenal (HPA) axis induced by CSDS and CUMS, but also notably reversed the effects of CSDS and CUMS on SIK1, CRTC1, and CRTC1-CREB binding in the PVN of mice. AAV-based genetic knock-down of SIK1 in PVN neurons evidently abolished the antidepressant-like effects of escitalopram in mice.

Limitation

A shortage of this study is that only rodent models of depression were used, while human samples were not included.

Conclusions

In summary, regulating the SIK1-CRTC1 system in the PVN participates in the antidepressant mechanism of escitalopram, which extends the knowledge of the pharmacological actions of escitalopram.

Substances (4)

Materials
Procduct Name CAS Molecular Formula Supplier Price
Escitalopram 128196-01-0 C20H21FN2O 173 suppliers $34.00-$35005.00
Escitalopram 128196-01-0 C20H21FN2O 173 suppliers $34.00-$35005.00
Escitalopram 128196-01-0 C20H21FN2O 173 suppliers $34.00-$35005.00
Escitalopram 128196-01-0 C20H21FN2O 173 suppliers $34.00-$35005.00

Similar articles

IF:7.4

Neurobiological and clinical effects of the antidepressant tianeptine.

CNS drugs Siegfried Kasper, Bruce S McEwen,etc Published: 1 January 2008
IF:2.6

Thymol produces an antidepressant-like effect in a chronic unpredictable mild stress model of depression in mice

Behavioural Brain Research Xue-Yang Deng , Hong-Yan Li ,etc Published: 15 September 2015
IF:7.7

Analysis on the involvement of phosphoglycerate mutase 1 in the aerobic glycolysis of melanoma cells

International Journal of Biological Macromolecules Qiang Wang, Zhongliang Lang,etc Published: 1 December 2024
特克斯县| 庆云县| 安西县| 德庆县| 黔西县| 前郭尔| 永宁县| 和田县| 潼关县| 武汉市| 北川| 张家川| 永宁县| 甘南县| 鄂温| 济阳县| 恭城| 枞阳县| 武隆县| 云安县| 宣恩县| 南宫市| 德安县| 石泉县| 新营市| 娱乐| 彩票| 永吉县| 乌拉特中旗| 昌宁县| 贵南县| 咸阳市| 启东市| 繁峙县| 梅河口市| 七台河市| 唐山市| 屏山县| 清远市| 洪泽县| 民县|