一二三四区视频,亚洲少妇熟女色,日本久热无码视频网,欧美国产日韩大尺度,亚洲a视频,久久少妇一区二区,日韩999无码视频,刺激久久久久久久,啊啊啊啊不要啊在线

ChemicalBook >> journal list >> Science Advances >>article
Science Advances

Science Advances

IF: 11.7
Download PDF

Neuropilin 1 is an entry receptor for KSHV infection of mesenchymal stem cell through TGFBR1/2-mediated macropinocytosis.

Published:24 May 2023 DOI: 10.1126/sciadv.adg1778 PMID: 37224259
Zheng-Zhou?Lu, Cong?Sun, Xiaolin?Zhang, Yingying?Peng, Yan?Wang, Yan?Zeng, Nannan?Zhu, Yan?Yuan, Mu-Sheng?Zeng

Abstract

Kaposi’s sarcoma–associated herpesvirus (KSHV) has been implicated in the pathogenesis of Kaposi’s sarcoma (KS) and other malignancies. The cellular origin of KS has been suggested to be either mesenchymal stem cells (MSCs) or endothelial cells. However, receptor(s) for KSHV to infect MSCs remains unknown. By combining bioinformatics analysis and shRNA screening, we identify neuropilin 1 (NRP1) as an entry receptor for KSHV infection of MSCs. Functionally, NRP1 knockout and overexpression in MSCs significantly reduce and promote, respectively, KSHV infection. Mechanistically, NRP1 facilitated the binding and internalization of KSHV by interacting with KSHV glycoprotein B (gB), which was blocked by soluble NRP1 protein. Furthermore, NRP1 interacts with TGF-β receptor type 2 (TGFBR2) through their respective cytoplasmic domains and thus activates the TGFBR1/2 complex, which facilitates the macropinocytosis-mediated KSHV internalization via the small GTPases Cdc42 and Rac1. Together, these findings implicate that KSHV has evolved a strategy to invade MSCs by harnessing NRP1 and TGF-beta receptors to stimulate macropinocytosis.

Substances (5)

Materials Related products
Procduct Name CAS Molecular Formula Supplier Price
LY2109761 700874-71-1 C26H27N5O2 161 suppliers $15.00-$2691.10
LY2109761 700874-71-1 C26H27N5O2 161 suppliers $15.00-$2691.10

Similar articles

IF:96.2

A preliminary study of ritonavir, an inhibitor of HIV-1 protease, to treat HIV-1 infection.

New England Journal of Medicine M Markowitz, M Saag,etc Published: 7 December 1995
IF:4.3

Escape from human immunodeficiency virus type 1 (HIV-1) entry inhibitors.

ACS Applied Electronic Materials Christopher J De Feo, Carol D Weiss,etc Published: 1 December 2012
志丹县| 邛崃市| 松滋市| 漳浦县| 鲁甸县| 靖远县| 蒙城县| 体育| 青海省| 金溪县| 葵青区| 五指山市| 亳州市| 鹿邑县| 长春市| 普安县| 哈巴河县| 漳平市| 滁州市| 松桃| 台前县| 海林市| 灵川县| 淮南市| 沂源县| 莎车县| 南澳县| 赤城县| 丁青县| 错那县| 肇庆市| 岑巩县| 武穴市| 弥渡县| 上林县| 武强县| 乌苏市| 乌审旗| 祁东县| 同德县| 吴桥县|