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Cancer research
Cancer research
IF:16.6
CiteScore:16.1
Articles:7677
Cancer Research, published by the American Association for Cancer Research (AACR), is a journal that focuses on impactful original studies, reviews, and opinion pieces relevant to the broad cancer research community. Manuscripts that present conceptual or technological advances leading to insights into cancer biology are particularly sought after. The journal also places emphasis on convergence science, which involves bridging multiple distinct areas of cancer research.
With primary subsections including Cancer Biology, Cancer Immunology, Cancer Metabolism and Molecular Mechanisms, Translational Cancer Biology, Cancer Landscapes, and Convergence Science, Cancer Research has a comprehensive scope. It is published twice a month and has one volume per year, with a print ISSN of 0008-5472 and an online ISSN of 1538-7445.
Cancer Research is abstracted and/or indexed in various databases and platforms, including BIOSIS Previews (R) Database, MEDLINE, Current Contents/Life Sciences, Current Contents/Clinical Medicine, Science Citation Index, Scopus, and Web of Science.
Lipid Composition Alters Ferroptosis Sensitivity
Published: 5 September 2025
DOI: 10.1158/0008-5472.CAN-24-4207
Vivian S. Park, Lauren E. Pope, Justin P. Ingram, Grace A. Alchemy, Julie J. Purkal, Magdalena B. Murray, Sha Jin, Eli Y. Andino-Frydman, Sanjana Singh, Anlu Chen, Priya Narayanan, Sarah Kongpachith, Darren C. Phillips, Scott J. Dixon, Relja Popovic
Vivian S. Park, Lauren E. Pope, Justin P. Ingram, Grace A. Alchemy, Julie J. Purkal, Magdalena B. Murray, Sha Jin, Eli Y. Andino-Frydman, Sanjana Singh, Anlu Chen, Priya Narayanan, Sarah Kongpachith, Darren C. Phillips, Scott J. Dixon, Relja Popovic
CLK2 Regulates the KEAP1/NRF2 and p53 Pathways to Suppress Ferroptosis in Colorectal Cancer
Published: 29 August 2025
DOI: 10.1158/0008-5472.CAN-24-4949
Hai-Meng Zhou, Yi Liu, Feng Shi, Hao-Wen Qiu, Le Li, Qi-Peng Shu, Yu-Ying Liu, Bai-Qi Wang, Meng Gao, Run-Lei Du, Shao-Bo Ke, Xiao-Dong Zhang
Hai-Meng Zhou, Yi Liu, Feng Shi, Hao-Wen Qiu, Le Li, Qi-Peng Shu, Yu-Ying Liu, Bai-Qi Wang, Meng Gao, Run-Lei Du, Shao-Bo Ke, Xiao-Dong Zhang
Loss of SETD8 Impairs Mitochondrial Homeostasis to Suppress Leukemia Stem Cell Function in t(8;21) Acute Myeloid Leukemia
Published: 29 August 2025
DOI: 10.1158/0008-5472.CAN-24-3659
Yongwei Su, Shuyi Li, Lei Wang, Yiran Wang, Shujiao He, Xiaotong Li, Jingqiao Qiao, Jingfeng Zhou, Li Yu
Yongwei Su, Shuyi Li, Lei Wang, Yiran Wang, Shujiao He, Xiaotong Li, Jingqiao Qiao, Jingfeng Zhou, Li Yu
Exon Skipping of Ste20-Like Kinase Enhances Glycolysis and Tumor Progression by Activating Enolase 1-Mediated Phosphoenolpyruvate Production
Published: 1 August 2025
DOI: 10.1158/0008-5472.CAN-25-0523
Zeyu Chen, Jingyu Liao, Chang Zhu, Ruizhi Chang, Huifang Liang, Zeyang Ding, Zhao Huang, Xiaoping Chen, Junnan Liang, Bixiang Zhang
Zeyu Chen, Jingyu Liao, Chang Zhu, Ruizhi Chang, Huifang Liang, Zeyang Ding, Zhao Huang, Xiaoping Chen, Junnan Liang, Bixiang Zhang
Reactivating cGAS-STING Signaling by Targeting SOS1 Enhances Antitumor Immunity in NRAS-Mutant Tumors
Published: 20 May 2025
DOI: 10.1158/0008-5472.CAN-24-2983
Jia-Lu Shan,Kai-Ming Zhang,Wen-Qing Zhong,Xiao-Yu Yang,Zhi-Ling Li,Yun Huang,Tian Du,Dong Yang,Jia-Hong Tang,Yu-Hong Chen,Hai-Liang Zhang,Xiao-Feng Zhu,Rong Deng
Jia-Lu Shan,Kai-Ming Zhang,Wen-Qing Zhong,Xiao-Yu Yang,Zhi-Ling Li,Yun Huang,Tian Du,Dong Yang,Jia-Hong Tang,Yu-Hong Chen,Hai-Liang Zhang,Xiao-Feng Zhu,Rong Deng
Gain-of-Function Chromatin Remodeling Activity of Oncogenic FOXL2-C134W Reprograms Glucocorticoid Receptor Occupancy to Drive Granulosa Cell Tumors
Published: 9 December 2024
DOI: 10.1158/0008-5472.CAN-24-2341
Thomas Welte, Veena K. Vuttaradhi, Eleonora Y. Khlebus, Allison Brodsky, Alejandra Flores Legarreta, Joseph Celestino, Reid T. Powell, Clifford C. Stephan, Nghi Nguyen, Jian Li, Shiro Takamatsu, Katherine Calzoncinth, Anil K. Sood, David M. Gershenson, P. Andrew Futreal, Barrett Lawson, Robert Tyler. Hillman
Thomas Welte, Veena K. Vuttaradhi, Eleonora Y. Khlebus, Allison Brodsky, Alejandra Flores Legarreta, Joseph Celestino, Reid T. Powell, Clifford C. Stephan, Nghi Nguyen, Jian Li, Shiro Takamatsu, Katherine Calzoncinth, Anil K. Sood, David M. Gershenson, P. Andrew Futreal, Barrett Lawson, Robert Tyler. Hillman
Targeting Super-Enhancer-Driven Transcriptional Dependencies Suppresses Aberrant Hedgehog Pathway Activation and Overcomes Smoothened Inhibitor Resistance
Published: 15 August 2024
DOI: 10.1158/0008-5472.CAN-23-3306
Yi Sui,?Teng Wang,?Yanqing Mei,?Ying Zhu,?Wenyan Jiang,?Jiayi Shen,?Siyuan Yan,?Wenjie Lu,?Kewen Zhao,?Jialin Mo,?Chaochen Wang,?Yujie Tang
Yi Sui,?Teng Wang,?Yanqing Mei,?Ying Zhu,?Wenyan Jiang,?Jiayi Shen,?Siyuan Yan,?Wenjie Lu,?Kewen Zhao,?Jialin Mo,?Chaochen Wang,?Yujie Tang
The Circadian Clock Component RORA Increases Immunosurveillance in Melanoma by Inhibiting PD-L1 Expression
Published: 15 July 2024
DOI: 10.1158/0008-5472.CAN-23-3942
Dandan Liu,?Benliang Wei,?Long Liang,?Yue Sheng,?Shengjie Sun,?Xing Sun,?Maohua Li,?Haobo Li,?Chaoying Yang,?Yuanliang Peng,?Yifang Xie,?Chengcai Wen,?Lu Chen,?Xionghao Liu,?Xiang Chen,?Hong Liu,?Jing Liu
Dandan Liu,?Benliang Wei,?Long Liang,?Yue Sheng,?Shengjie Sun,?Xing Sun,?Maohua Li,?Haobo Li,?Chaoying Yang,?Yuanliang Peng,?Yifang Xie,?Chengcai Wen,?Lu Chen,?Xionghao Liu,?Xiang Chen,?Hong Liu,?Jing Liu
ASPSCR1::TFE3 Drives Alveolar Soft Part Sarcoma by Inducing Targetable Transcriptional Programs
Published: 24 April 2024
DOI: 10.1158/0008-5472.CAN-23-2115
Ewa Sicinska, Vijaya Sudhakara Rao Kola, Joseph A. Kerfoot, Madeleine L. Taddei, Alyaa Al-Ibraheemi, Yi-Hsuan Hsieh, Alanna J. Church, Esther Landesman-Bollag, Yosef Landesman, Matthew L. Hemming
Ewa Sicinska, Vijaya Sudhakara Rao Kola, Joseph A. Kerfoot, Madeleine L. Taddei, Alyaa Al-Ibraheemi, Yi-Hsuan Hsieh, Alanna J. Church, Esther Landesman-Bollag, Yosef Landesman, Matthew L. Hemming
Targeting the epigenetic reader ENL inhibits super-enhancer-driven oncogenic transcription and synergizes with BET inhibition to suppress tumor progression
Published: 15 April 2024
DOI: 10.1158/0008-5472.CAN-23-1836
Yongheng Chen,?Ying Ying,?Wenlong Ma,?Hongchao Ma,?Liang Shi,?Xuefeng Gao,?Min Jia,?Meiqi Li,?Xiaoman Song,?Weixiao Kong,?Wei Chen,?Xiangyi Zheng,?Tobias Achu Muluh,?Xiaobin Wang,?Maolin Wang,?Xing-Sheng Shu
Yongheng Chen,?Ying Ying,?Wenlong Ma,?Hongchao Ma,?Liang Shi,?Xuefeng Gao,?Min Jia,?Meiqi Li,?Xiaoman Song,?Weixiao Kong,?Wei Chen,?Xiangyi Zheng,?Tobias Achu Muluh,?Xiaobin Wang,?Maolin Wang,?Xing-Sheng Shu
Breast Cancer Stem Cells Secrete MIF to Mediate Tumor Metabolic Reprogramming that Drives Immune Evasion
Published: 15 April 2024
DOI: 10.1158/0008-5472.CAN-23-2390
Linlin Yan,?Mingming Wu,?Tianyu Wang,?Hui Yuan,?Xiao Zhang,?Huafeng Zhang,?Tao Li,?Vijay Pandey,?Xinghua Han,?Peter E Lobie,?Tao Zhu
Linlin Yan,?Mingming Wu,?Tianyu Wang,?Hui Yuan,?Xiao Zhang,?Huafeng Zhang,?Tao Li,?Vijay Pandey,?Xinghua Han,?Peter E Lobie,?Tao Zhu
Foretinib Is Effective in Acute Myeloid Leukemia by Inhibiting FLT3 and Overcoming Secondary Mutations That Drive Resistance to Quizartinib and Gilteritinib
Published: 15 March 2024
DOI: 10.1158/0008-5472.CAN-23-1534
Peihong Wang,?Yvyin Zhang,?Rufang Xiang,?Jie Yang,?Yanli Xu,?Tingfen Deng,?Wei Zhou,?Caixia Wang,?Xinhua Xiao,?Shunqing Wang
Peihong Wang,?Yvyin Zhang,?Rufang Xiang,?Jie Yang,?Yanli Xu,?Tingfen Deng,?Wei Zhou,?Caixia Wang,?Xinhua Xiao,?Shunqing Wang
Androgen Receptor Variants Confer Castration Resistance in Prostate Cancer by Counteracting Antiandrogen-Induced Ferroptosis
Published: 2 October 2023
DOI: 10.1158/0008-5472.CAN-23-0285
Rui Sun,?Binyuan Yan,?Hao Li,?Donglin Ding,?Liguo Wang,?Jun Pang,?Dingwei Ye,?Haojie Huang
Rui Sun,?Binyuan Yan,?Hao Li,?Donglin Ding,?Liguo Wang,?Jun Pang,?Dingwei Ye,?Haojie Huang
ESRRB Inhibits the TGFβ Signaling Pathway to Drive Cell Proliferation in Cervical Cancer
Published: 15 September 2023
DOI: 10.1158/0008-5472.CAN-23-0067
Qin-Shu Li,?Peng-Sheng Zheng
Qin-Shu Li,?Peng-Sheng Zheng
Alpha-1 adrenergic antagonists sensitize neuroblastoma to therapeutic differentiation
Published: 15 August 2023
DOI: 10.1158/0008-5472.CAN-22-1913
Francesca Broso, Pamela Gatto, Viktoryia Sidarovich, Chiara Ambrosini, Veronica De Sanctis, Roberto Bertorelli, Elena Zaccheroni, Benedetta Ricci, Eliana Destefanis, Sara Longhi, Enrico Sebastiani, Toma Tebaldi, Valentina Adami, Alessandro Quattrone
Francesca Broso, Pamela Gatto, Viktoryia Sidarovich, Chiara Ambrosini, Veronica De Sanctis, Roberto Bertorelli, Elena Zaccheroni, Benedetta Ricci, Eliana Destefanis, Sara Longhi, Enrico Sebastiani, Toma Tebaldi, Valentina Adami, Alessandro Quattrone
Retinol saturase mediates retinoid metabolism to impair a ferroptosis defense system in cancer cells
Published: 14 July 2023
DOI: 10.1158/0008-5472.CAN-22-3977
Guoshu Bi,?Jiaqi Liang,?Guangyao Shan,?Yunyi Bian,?Zhencong Chen,?Yiwei Huang,?Tao Lu,?Ming Li,?Valeria Besskaya,?Mengnan Zhao,?Hong Fan,?Qun Wang,?Boyi Gan,?Cheng Zhan
Guoshu Bi,?Jiaqi Liang,?Guangyao Shan,?Yunyi Bian,?Zhencong Chen,?Yiwei Huang,?Tao Lu,?Ming Li,?Valeria Besskaya,?Mengnan Zhao,?Hong Fan,?Qun Wang,?Boyi Gan,?Cheng Zhan
Cancer-Associated Fibroblast–Derived miR-146a-5p Generates a Niche That Promotes Bladder Cancer Stemness and Chemoresistance
Published: 15 May 2023
DOI: 10.1158/0008-5472.CAN-22-2213
Junlong Zhuang, Lan Shen, Meiqian Li, Jingya Sun, Jiange Hao, Jiaxuan Li, Zhen Zhu, Shuning Ge, Dianzheng Zhang, Hongqian Guo, Ruimin Huang, Jun Yan
Junlong Zhuang, Lan Shen, Meiqian Li, Jingya Sun, Jiange Hao, Jiaxuan Li, Zhen Zhu, Shuning Ge, Dianzheng Zhang, Hongqian Guo, Ruimin Huang, Jun Yan
Androgen Signaling Contributes to Sex Differences in Cancer by Inhibiting NF-κB Activation in T Cells and Suppressing Antitumor Immunity
Published: 15 March 2023
DOI: 10.1158/0008-5472.CAN-22-2405
Xiaomin Zhang, Limin Cheng, Chengqi Gao, Jing Chen, Shuangye Liao, Yongqiang Zheng, Liping Xu, Jingjing He, Danyang Wang, Ziqian Fang, Jianeng Zhang, Min Yan, Yi Luan, Siyu Chen, Likun Chen, Xiaojun Xia, Chunhao Deng, Guokai Chen, Wende Li, Zexian Liu, Penghui Zhou
Xiaomin Zhang, Limin Cheng, Chengqi Gao, Jing Chen, Shuangye Liao, Yongqiang Zheng, Liping Xu, Jingjing He, Danyang Wang, Ziqian Fang, Jianeng Zhang, Min Yan, Yi Luan, Siyu Chen, Likun Chen, Xiaojun Xia, Chunhao Deng, Guokai Chen, Wende Li, Zexian Liu, Penghui Zhou
SARS-CoV-2 pseudovirus enters the host cells through spike protein-CD147 in an Arf6-dependent manner
Published: 1 December 2022
DOI: 10.1080/22221751.2022.2059403
Yun-Qi Zhou,?Ke Wang,?Xue-Yan Wang,?Hong-Yong Cui,?Yongxiang Zhao,?Ping Zhu,?Zhi-Nan Chen
Yun-Qi Zhou,?Ke Wang,?Xue-Yan Wang,?Hong-Yong Cui,?Yongxiang Zhao,?Ping Zhu,?Zhi-Nan Chen
EBV infection in epithelial malignancies induces resistance to antitumor natural killer cells via F3-mediated platelet aggregation
Published: 15 March 2022
DOI: 10.1158/0008-5472.can-21-2292
Xiaobing Duan, Haiwen Chen, Xiang Zhou, Pingjuan Liu, Xiao Zhang, Qian Zhu, Ling Zhong, Wanlin Zhang, Shanshan Zhang, Xinyu Zhang, Yanhong Chen, Yan Zhou, Chaopin Yang, Qisheng Feng, Yi-Xin Zeng, Miao Xu, Tong Xiang
Xiaobing Duan, Haiwen Chen, Xiang Zhou, Pingjuan Liu, Xiao Zhang, Qian Zhu, Ling Zhong, Wanlin Zhang, Shanshan Zhang, Xinyu Zhang, Yanhong Chen, Yan Zhou, Chaopin Yang, Qisheng Feng, Yi-Xin Zeng, Miao Xu, Tong Xiang