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Genome Biology

Genome Biology

IF:10.1 CiteScore:21 Articles:241
Genome Biology stands as a premier platform for exceptional research across all domains of biology and biomedicine, explored through a genomic and post-genomic lens. With an impressive impact factor of 12.3 (2022),* the journal secures its position as the 3rd-ranked research journal in the Genetics and Heredity category and the 2nd-ranked research journal in the Biotechnology and Applied Microbiology category by Thomson Reuters. Notably, Genome Biology holds the distinction of being the highest-ranked open-access journal in this category. Our dedicated team of highly trained in-house Editors collaborates closely with our esteemed Editorial Board of international experts, ensuring the journal remains on the forefront of scientific advances and community standards. Regular engagement with researchers at conferences and institute visits underscores our commitment to staying abreast of the latest developments in the field.

Artemisinin alleviates Parkinson’s disease by targeting Adcy5-Gch1 axis to trigger a cascade generation of BH4 and dopamine in rats

Published: 4 September 2025 DOI: 10.1186/s13059-025-03712-5
Xin-xing Yang, Guo-qing Wang, Qian Wen, Yu-jia Zhao, Dai-di Li, Feng Zhang

Post-cleavage target residence determines asymmetry in non-homologous end joining of Cas12a-induced DNA double strand breaks

Published: 14 April 2025 DOI: 10.1186/s13059-025-03567-w
Ruo-Dan Chen, Yi Yang, Kun-Ming Liu, Jing-Zhen Hu, Yi-Li Feng, Chun-Yi Yang, Rui-Rui Jiang, Si-Cheng Liu, Yue Wang, Ping-An Han, Ru-Gang Tian, Yu-Long Wang, Shi-Ming Xu, An-Yong Xie

The collateral activity of RfxCas13d can induce lethality in a RfxCas13d knock-in mouse model

Published: 1 February 2023 DOI: 10.1186/s13059-023-02860-w
Yunfei Li,?Junjie Xu,?Xuefei Guo,?Zhiwei Li,?Lili Cao,?Shengde Liu,?Ying Guo,?Guodong Wang,?Yujie Luo,?Zeming Zhang,?Xuemei Wei,?Yingchi Zhao,?Tongtong Liu,?Xiao Wang,?Huawei Xia,?Ming Kuang,?Qirui Guo,?Junhong Li,?Luoying Chen,?Yibing Wang,?Qi Li,?Fengchao Wang,?Qinghua Liu,?Fuping You

G-quadruplexes sense natural porphyrin metabolites for regulation of gene transcription and chromatin landscapes.

Published: 15 December 2022 DOI: 10.1186/s13059-022-02830-8
Conghui Li,?Zhinang Yin,?Ruijing Xiao,?Beili Huang,?Yali Cui,?Honghong Wang,?Ying Xiang,?Lingrui Wang,?Lingyu Lei,?Jiaqin Ye,?Tianyu Li,?Youquan Zhong,?Fangteng Guo,?Yuchen Xia,?Pingping Fang,?Kaiwei Liang

RNA methylomes reveal the m6A-mediated regulation of DNA demethylase gene SlDML2 in tomato fruit ripening

Published: 6 August 2019 DOI: 10.1186/s13059-019-1771-7
Leilei Zhou, Shiping Tian, Guozheng Qin
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