Chemical Safety Data Sheet MSDS / SDS
2-Chloro-4-methylaniline
Revision Date:2026-05-31Revision Number:1
Product identifier
- Product name: 2-Chloro-4-methylaniline
- CBnumber: CB4349929
- CAS: 615-65-6
- EINECS Number: 210-440-7
- Synonyms: 2-Chloro-4-methylaniline,Ortho Chloro Para Toluidine
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P273 Avoid release to the environment.
P501 Dispose of contents/container to..…
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P271 Use only outdoors or in a well-ventilated area.
P270 Do not eat, drink or smoke when using this product.
P264 Wash skin thouroughly after handling.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
Hazard statements
H373 May cause damage to organs through prolonged or repeated exposure
H331 Toxic if inhaled
H312 Harmful in contact with skin
H302 Harmful if swallowed
H412 Harmful to aquatic life with long lasting effects
H318 Causes serious eye damage
H315 Causes skin irritation
H402 Harmful to aquatic life
H372 Causes damage to organs through prolonged or repeated exposure
H370 Causes damage to organs
H319 Causes serious eye irritation
Substance
- Product name: 2-Chloro-4-methylaniline
- Synonyms: 2-Chloro-4-methylaniline,Ortho Chloro Para Toluidine
- CAS: 615-65-6
- EC number: 210-440-7
- MF: C7H8ClN
- MW: 141.6
4.1 Description of first-aid measures
General adviceShow this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. If breathing stops: mouth-to-mouth breathing or artificial respiration. Oxygen if necessary. Immediately call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Consult a physician.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.
Remove contact lenses.
If swallowed
Remove contact lenses.
After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
4.4 Notes to physician
No data available
5.1 Extinguishing media
Suitable extinguishing mediaWater Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Nitrogen oxides (NOx)
Hydrogen chloride gas
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
Nitrogen oxides (NOx)
Hydrogen chloride gas
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
2
0
0
| HEALTH | 2 | Intense or continued but not chronic exposure could cause temporary incapacitation or possible residual injury (e.g. diethyl ether, ammonium phosphate, iodine) | |
| FIRE | 0 | Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent material (e.g. Chemizorb? ).
Dispose of properly. Clean up affected area.
Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
Advice on safe handlingWork under hood. Do not inhale substance/mixture. Avoid generation of vapours/aerosols.
Hygiene measures
Immediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
For precautions see section 2.2.
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsTightly closed. Keep in a well-ventilated place. Keep locked up or in an area accessible only to qualified or authorized persons.
Storage class
Storage class (TRGS 510): 6.1C: Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
8.1 Control parameters
Ingredients with workplace control parametersContains no substances with occupational exposure limit values.
8.2 Exposure controls
Appropriate engineering controlsImmediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles
Skin protection
required
Body Protection
protective clothing
Respiratory protection
required when vapours/aerosols are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Control of environmental exposure
Do not let product enter drains.
Information on basic physicochemical properties
- a) Physical stateclear, liquid
- b) Colordark brown
- c) OdorNo data available
- d) Melting point/freezing pointMelting point/range: 7 °C - lit.
- e) Initial boiling point and boiling range223 - 225 °C - lit.
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsNo data available
- h) Flash point99 °C - closed cup
- i) Autoignition temperatureNo data available
- j) Decomposition temperatureNo data available
- k) pHNo data available
- l) ViscosityViscosity, kinematic: No data available
Viscosity, dynamic: No data available - m) Water solubilityNo data available
- n) Partition coefficient n-octanol/waterNo data available
- o) Vapor pressureNo data available
- p) Density1.151 g/mL at 25 °C - lit.
- Relative density1.151 g/mL at 25 °C (lit.)
- q) Relative vapor densityNo data available
- r) Particle characteristicsNo data available
- s) Explosive propertiesNo data available
- t) Oxidizing propertiesNo data available
- Solubilitymethanol: soluble
9.2 Other safety information
No data available
10.1 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.2 Possibility of hazardous reactions
No data available
10.3 Conditions to avoid
Strong heating.
10.4 Incompatible materials
Chloroformates, Strong oxidizing agents
10.5 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityOral: No data available
LD50 Oral - 500.1 mg/kg
LC50 Inhalation - 4 h - 11 mg/l - vapor (Acute toxicity estimate)
LD50 Dermal - 1,100 mg/kg
Skin corrosion/irritation
LD50 Oral - 500.1 mg/kg
LC50 Inhalation - 4 h - 11 mg/l - vapor (Acute toxicity estimate)
LD50 Dermal - 1,100 mg/kg
Skin - Rabbit
Result: Severe skin irritation
Serious eye damage/eye irritation
Result: Severe skin irritation
Eyes - Rabbit
Result: Severe eye irritation
Respiratory or skin sensitization
Result: Severe eye irritation
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Test Type: Rat
Test system: Liver
Remarks: Unscheduled DNA synthesis
Test Type: Ames test
Test system: S. typhimurium
Result: positive
Carcinogenicity
Test system: Liver
Remarks: Unscheduled DNA synthesis
Test Type: Ames test
Test system: S. typhimurium
Result: positive
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
RTECS: XU5110000 burning sensation, Cough, wheezing, laryngitis, Shortness of breath, Headache, Nausea,
Vomiting, Absorption into the body leads to the formation of methemoglobin which in sufficient concentration causes cyanosis. Onset may be delayed 2 to 4 hours or longer., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Vomiting, Absorption into the body leads to the formation of methemoglobin which in sufficient concentration causes cyanosis. Onset may be delayed 2 to 4 hours or longer., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
12.1 Toxicity
Toxicity to fish LC50 - Pimephales promelas (fathead minnow) - 35.9 mg/l - 96 h
12.2 Persistence and degradability
No data available
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
No data available
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Offer surplus and non-recyclable solutions to a licensed disposal company.
14.1 UN number
ADR/RID: 3429
IMDG: 3429
IATA-DGR: 3429
IMDG: 3429
IATA-DGR: 3429
14.2 UN proper shipping name
ADR/RID: CHLOROTOLUIDINES, LIQUID
IMDG: CHLOROTOLUIDINES, LIQUID
IATA-DGR: Chlorotoluidines, liquid
IMDG: CHLOROTOLUIDINES, LIQUID
IATA-DGR: Chlorotoluidines, liquid
14.3 Transport hazard class(es)
ADR/RID: 6.1
IMDG: 6.1
IATA-DGR: 6.1
IMDG: 6.1
IATA-DGR: 6.1
14.4 Packaging group
ADR/RID: III
IMDG: III
IATA-DGR: III
IMDG: III
IATA-DGR: III
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA-DGR: no
IMDG Marine pollutant: no
IATA-DGR: no
14.6 Special precautions for user
Based on chemical properties, choose appropriate tools and conditions of transport.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
14.7 Incompatible materials
Chloroformates, Strong oxidizing agents
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulatory information
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Regulations on Safety Management of Hazardous Chemicals
Catalogue of Hazardous Chemicals : Listed
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.