Chemical Safety Data Sheet MSDS / SDS
2-(TRIFLUOROMETHYL)PHENYL ISOCYANATE
Revision Date:2026-05-31Revision Number:1
Product identifier
- Product name: 2-(TRIFLUOROMETHYL)PHENYL ISOCYANATE
- CBnumber: CB3315011
- CAS: 2285-12-3
- EINECS Number: 218-925-5
- Synonyms: 1-isocyanato-2-(trifluoromethyl)benzene,2-(Trifluoromethyl)phenyl isocyanate
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P320 Specific treatment is urgent (see … on this label).
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501 Dispose of contents/container to..…
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P284 Wear respiratory protection.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P271 Use only outdoors or in a well-ventilated area.
P270 Do not eat, drink or smoke when using this product.
P264 Wash skin thouroughly after handling.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P240 Ground/bond container and receiving equipment.
P233 Keep container tightly closed.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
Hazard statements
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled
H330 Fatal if inhaled
H302 Harmful if swallowed
H335 May cause respiratory irritation
H319 Causes serious eye irritation
H315 Causes skin irritation
H226 Flammable liquid and vapour
Substance
- Product name: 2-(TRIFLUOROMETHYL)PHENYL ISOCYANATE
- Synonyms: 1-isocyanato-2-(trifluoromethyl)benzene,2-(Trifluoromethyl)phenyl isocyanate
- CAS: 2285-12-3
- EC number: 218-925-5
- MF: C8H4F3NO
- MW: 187.12
Eye Contact
Immediate medical attention is required. Rinse immediately with plenty of water, also under the eyelids, for at least 15 minutes.
Skin Contact
Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. Immediate medical attention is required.
Inhalation
Remove from exposure, lie down. Remove to fresh air. If not breathing, give artificial respiration. Immediate medical attention is required.
Ingestion
Call a physician immediately. Clean mouth with water.
Most important symptoms and effects
Difficulty in breathing. May cause allergy or asthma symptoms or breathing difficulties if inhaled. Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting: Symptoms of allergic reaction may include rash, itching, swelling, trouble breathing, tingling of the hands and feet, dizziness, lightheadedness, chest pain, muscle pain or flushing
Self-Protection of the First Aider
Ensure that medical personnel are aware of the material(s) involved, take precautions to protect themselves and prevent spread of contamination.
Notes to Physician
Treat symptomatically.
Suitable Extinguishing Media
Water spray. Carbon dioxide (CO2). Dry chemical. Chemical foam. Water mist may be used to cool closed containers.
Extinguishing media which must not be used for safety reasons
No information available.
Specific Hazards Arising from the Chemical
Combustible material. Flammable. Containers may explode when heated. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back.
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.
NFPA 704
4
2
0
| HEALTH | 4 | Very short exposure could cause death or major residual injury (e.g. hydrogen cyanide, phosgene, methyl isocyanate, hydrofluoric acid) | |
| FIRE | 2 | Must be moderately heated or exposed to relatively high ambient temperature before ignition can occur and multiple finely divided suspended solids that do not require heating before ignition can occur. Flash point between 37.8 and 93.3 °C (100 and 200 °F). (e.g. diesel fuel, sulfur) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal Precautions
Remove all sources of ignition. Take precautionary measures against static discharges.
Environmental Precautions
See Section 12 for additional Ecological Information.
Methods for Containment and Clean Up
Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, sawdust). Keep in suitable, closed containers for disposal. Wear self-contained breathing apparatus and protective suit. Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment. Do not let this chemical enter the environment.
Refer to protective measures listed in Sections 8 and 13.
Refer to protective measures listed in Sections 8 and 13.
Handling
Do not breathe mist/vapors/spray. Do not get in eyes, on skin, or on clothing. Do not ingest. If swallowed then seek immediate medical assistance. Handle product only in closed system or provide appropriate exhaust ventilation. Use spark-proof tools and explosion-proof equipment. Use only non-sparking tools. Keep away from open flames, hot surfaces and sources of ignition. Take precautionary measures against static discharges.
Storage
Keep in a dry place. Keep container tightly closed. Keep away from heat, sparks and flame. Keep refrigerated. Keep container tightly closed in a dry and well-ventilated place.
Specific Use(s)
Use in laboratories
Control Parameters
Monitoring methods
BS EN 14042:2003 Title Identifier: Workplace atmospheres. Guide for the application and use of procedures for the assessment of exposure to chemical and biological agents. MDHS70 General methods for sampling airborne gases and vapours MDHS 88
Volatile organic compounds in air. Laboratory method using diffusive samplers, solvent desorption and gas chromatography MDHS 96 Volatile organic compounds in air - Laboratory method using pumped solid sorbent tubes, solvent desorption and gas chromatography
Volatile organic compounds in air. Laboratory method using diffusive samplers, solvent desorption and gas chromatography MDHS 96 Volatile organic compounds in air - Laboratory method using pumped solid sorbent tubes, solvent desorption and gas chromatography
Exposure Controls
Engineering Measures
Ensure adequate ventilation, especially in confined areas. Ensure that eyewash stations and safety showers are close to the workstation location. Use explosion-proof electrical/ventilating/lighting equipment. Wherever possible, engineering control measures such as the isolation or enclosure of the process, the introduction of process or equipment changes to minimise release or contact, and the use of properly designed ventilation systems, should be adopted to control hazardous materials at source.
Personal protective equipment
Eye ProtectionGoggles (European standard - EN 166)
Hand Protection
Protective gloves
Inspect gloves before use.
Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion.
Remove gloves with care avoiding skin contamination.
Skin and body protection
| Glove material | Breakthrough time | Glove thickness | EU standard | Glove comments |
|---|---|---|---|---|
| Nitrile rubber | See manufacturers | - | EN 374 | (minimum requirement) |
| Neoprene | recommendations | |||
| Natural rubber | ||||
| PVC |
Inspect gloves before use.
Please observe the instructions regarding permeability and breakthrough time which are provided by the supplier of the gloves.
(Refer to manufacturer/supplier for information)
Ensure gloves are suitable for the task: Chemical compatability, Dexterity, Operational conditions, User susceptibility, e.g.
sensitisation effects, also take into consideration the specific local conditions under which the product is used, such as the danger of cuts, abrasion.
Remove gloves with care avoiding skin contamination.
Wear appropriate protective gloves and clothing to prevent skin exposure
Respiratory Protection
When workers are facing concentrations above the exposure limit they must use appropriate certified respirators.
To protect the wearer, respiratory protective equipment must be the correct fit and be used and maintained properly
To protect the wearer, respiratory protective equipment must be the correct fit and be used and maintained properly
Large scale/emergency use
Use a NIOSH/MSHA or European Standard EN 136 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced
Recommended Filter type: Organic gases and vapours filter Type A Brown conforming to
EN14387
Recommended Filter type: Organic gases and vapours filter Type A Brown conforming to
EN14387
Small scale/Laboratory use
Use a NIOSH/MSHA or European Standard EN 149:2001 approved respirator if exposure limits are exceeded or if irritation or other symptoms are experienced.
Recommended half mask:- Valve filtering: EN405; or; Half mask: EN140; plus filter, EN 141
When RPE is used a face piece Fit Test should be conducted
Recommended half mask:- Valve filtering: EN405; or; Half mask: EN140; plus filter, EN 141
When RPE is used a face piece Fit Test should be conducted
Hygiene Measures
Handle in accordance with good industrial hygiene and safety practice.
Environmental exposure controls
No information available.
Information on basic physicochemical properties
- ColourClear colorless to light yellow
- Explosion LimitsNo data available
- Molecular Weight187.12
- Molecular FormulaC8 H4 F3 N O
- Oxidizing PropertiesNo information available
- Explosive Propertiesexplosive air/vapour mixtures possible
- ViscosityNo data available
- Decomposition TemperatureNo data available
- Autoignition TemperatureNo data available
- Partition Coefficient (n-octanol/water)No data available
- Solubility in other solventsNo information available
- Water SolubilityHydrolyzes in water.
- Bulk DensityNot applicable Liquid
- Specific Gravity / Density1.230
- Vapor DensityNo data available (Air = 1.0)
- Vapor PressureNo data available
- Flammability (solid,gas)Not applicable Liquid
- Evaporation RateNo data available
- Flash Point58 °C / 136.4 °F Method - No information available
- Boiling Point/Range75°C 40mm
- Softening PointNo data available
- Melting Point/RangeNo data available
- pHNo information available
- Odor ThresholdNo data available
- OdorOdorless
- Physical StateLiquid
- AppearanceLight yellow
Stability
Stable under normal conditions. Moisture sensitive.
Hazardous Reactions
No information available.
Hazardous Polymerization
No information available.
Conditions to Avoid
Excess heat. Incompatible products. Exposure to moist air or water. Keep away from open flames, hot surfaces and sources of ignition.
Materials to avoid
Acids. Water. Strong oxidizing agents. Strong bases. Alcohols. Amines.
Hazardous Decomposition Products
Nitrogen oxides (NOx). Carbon monoxide (CO). Carbon dioxide (CO2). Hydrogen cyanide (hydrocyanic acid). Gaseous hydrogen fluoride (HF).
Product Information
(a) acute toxicity;
| Component | LD50 Oral | LD50 Dermal | LC50 Inhalation |
|---|---|---|---|
| .alpha.,.alpha.,.alpha.-Trifluoro-o-tolyl isocyanate | LD50 = 7 g/kg ( Rat ) |
(b) skin corrosion/irritation;
Category 2
(c) serious eye damage/irritation;
Category 2
(d) respiratory or skin sensitization;
RespiratoryCategory 1
Skin
No data available
No information available
No information available
(e) germ cell mutagenicity;
No data available
(f) carcinogenicity;
No data available
There are no known carcinogenic chemicals in this product
There are no known carcinogenic chemicals in this product
(g) reproductive toxicity;
No data available
(h) STOT-single exposure;
Category 3
Results / Target organs
Respiratory system
(i) STOT-repeated exposure;
No data available
Target Organs
No information available.
(j) aspiration hazard;
No data available
Other Adverse Effects
The toxicological properties have not been fully investigated.
Symptoms / effects,both acute and delayed
Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting:
Symptoms of allergic reaction may include rash, itching, swelling, trouble breathing, tingling of the hands and feet, dizziness, lightheadedness, chest pain, muscle pain or flushing
Symptoms of allergic reaction may include rash, itching, swelling, trouble breathing, tingling of the hands and feet, dizziness, lightheadedness, chest pain, muscle pain or flushing
Ecotoxicity effects
Do not empty into drains.
Persistence and Degradability
No information available
Bioaccumulative Potential
No information available
Mobility in soil
No information available
Endocrine Disruptor Information
This product does not contain any known or suspected endocrine disruptors
Persistent Organic Pollutant
This product does not contain any known or suspected substance
Ozone Depletion Potential
This product does not contain any known or suspected substance
Waste from Residues/Unused Products
Waste is classified as hazardous. Dispose of in accordance with the European Directives on waste and hazardous waste. Dispose of in accordance with local regulations.
Contaminated Packaging
Dispose of this container to hazardous or special waste collection point. Empty containers retain product residue, (liquid and/or vapor), and can be dangerous. Keep product and empty container away from heat and sources of ignition.
Other Information
Waste codes should be assigned by the user based on the application for which the product was used. Do not flush to sewer. Can be landfilled or incinerated, when in compliance with local regulations.
Road and Rail Transport
UN-NoUN3384
Proper Shipping Name
TOXIC BY INHALATION LIQUID, FLAMMABLE, N.O.S.
Technical Shipping Name
.alpha.,.alpha.,.alpha.-Trifluoro-o-tolyl isocyanate
Hazard Class
6.1
Subsidiary Hazard Class
3
Packing Group
I
IMDG/IMO
UN-NoUN3384
Proper Shipping Name
TOXIC BY INHALATION LIQUID, FLAMMABLE, N.O.S.
Technical Shipping Name
.alpha.,.alpha.,.alpha.-Trifluoro-o-tolyl isocyanate
Hazard Class
6.1
Subsidiary Hazard Class
3
Packing Group
I
IATA
FORBIDDEN FOR IATA TRANSPORT
UN-No
UN3384
Proper Shipping Name
TOXIC BY INHALATION LIQUID, FLAMMABLE, N.O.S.*, FORBIDDEN FOR IATA
TRANSPORT
Technical Shipping Name
TRANSPORT
.alpha.,.alpha.,.alpha.-Trifluoro-o-tolyl isocyanate
Hazard Class
6.1
Subsidiary Hazard Class
3
Packing Group
I
Special Precautions for User
No special precautions required
International Inventories
X = listed, China (IECSC), Europe (EINECS/ELINCS/NLP), U.S.A. (TSCA), Canada (DSL/NDSL), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), Korea (KECL).
| Component | The Inventory of Hazardous Chemicals (2015 Edition) | List of dangerous goods GB 12268 - 2012 | TCSI | IECSC | EINECS | TSCA | DSL | PICCS | ENCS | ISHL | AICS | KECL |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| .alpha.,.alpha.,.alpha.- Trifluoro-o-tolyl isocyanate | - | - | X | - | 218-925-5 | - | - | - | - | - | - |
National Regulations
Prepared By
Health, Safety and Environmental Department
Revision Date
07-Sep-2025
Revision Summary
Not applicable.
Training Advice
Chemical hazard awareness training, incorporating labelling, Safety Data Sheets (SDS), Personal Protective Equipment (PPE) and hygiene.
Use of personal protective equipment, covering appropriate selection, compatibility, breakthrough thresholds, care, maintenance, fit and standards.
First aid for chemical exposure, including the use of eye wash and safety showers.
Use of personal protective equipment, covering appropriate selection, compatibility, breakthrough thresholds, care, maintenance, fit and standards.
First aid for chemical exposure, including the use of eye wash and safety showers.
Legend
CASChemical Abstracts Service
TSCA
United States Toxic Substances Control Act Section 8(b)
Inventory
EINECS/ELINCS
Inventory
European Inventory of Existing Commercial Chemical
Substances/EU List of Notified Chemical Substances
DSL/NDSL
Substances/EU List of Notified Chemical Substances
Canadian Domestic Substances List/Non-Domestic
Substances List
PICCS
Substances List
Philippines Inventory of Chemicals and Chemical Substances
ENCS
Japanese Existing and New Chemical Substances
IECSC
Chinese Inventory of Existing Chemical Substances
AICS
Australian Inventory of Chemical Substances
KECL
Korean Existing and Evaluated Chemical Substances
NZIoC
New Zealand Inventory of Chemicals
WEL
Workplace Exposure Limit
TWA
Time Weighted Average
ACGIH
American Conference of Governmental Industrial Hygienists
IARC
International Agency for Research on Cancer
DNEL
Derived No Effect Level
PNEC
Predicted No Effect Concentration
RPE
Respiratory Protective Equipment
LD50
Lethal Dose 50%
LC50
Lethal Concentration 50%
EC50
Effective Concentration 50%
NOEC
No Observed Effect Concentration
POW
Partition coefficient Octanol:Water
PBT
Persistent, Bioaccumulative, Toxic
vPvB
very Persistent, very Bioaccumulative
ICAO/IATA
International Civil Aviation Organization/International Air
Transport Association
IMO/IMDG
Transport Association
International Maritime Organization/International Maritime
Dangerous Goods Code
ADR
Dangerous Goods Code
European Agreement Concerning the International Carriage of
Dangerous Goods by Road
MARPOL
Dangerous Goods by Road
International Convention for the Prevention of Pollution from
Ships
OECD
Ships
Organisation for Economic Co-operation and Development
ATE
Acute Toxicity Estimate
BCF
Bioconcentration factor
VOC
(Volatile Organic Compound)
Key literature references and sources for data
https://echa.europa.eu/information-on-chemicals
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS
Suppliers safety data sheet, Chemadvisor - LOLI, Merck index, RTECS
Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.
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