Chemical Safety Data Sheet MSDS / SDS
2,3,4,5-TETRACHLOROANILINE
Revision Date:2026-05-31Revision Number:1
Product identifier
- Product name: 2,3,4,5-TETRACHLOROANILINE
- CBnumber: CB9481297
- CAS: 634-83-3
- EINECS Number: 211-216-1
- Synonyms: 2，3，4，5-Tetrachloroaniline
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Hazard statements
H225 Highly Flammable liquid and vapour
H302 Harmful if swallowed
H312 Harmful in contact with skin
H319 Causes serious eye irritation
H332 Harmful if inhaled
Substance
- Product name: 2,3,4,5-TETRACHLOROANILINE
- Synonyms: 2，3，4，5-Tetrachloroaniline
- CAS: 634-83-3
- EC number: 211-216-1
- MF: C6H3Cl4N
- MW: 230.91
First Aid Measures
General adviceImmediate medical attention is required. In case of accident or unwellness, seek medical advice immediately (show directions for use or safety data sheet if possible). If symptoms persist, call a physician.
Eye contact
Immediately flush with plenty of water. After initial flushing, remove any contact lenses and continue flushing for at least 15 minutes. Keep eye wide open while rinsing. If symptoms persist, call a physician. Rinse thoroughly with plenty of water for at least 15 minutes, lifting lower and upper eyelids. Consult a physician.
Skin Contact
Wash off immediately with plenty of water. Immediate medical attention is not required.
Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. If skin irritation persists, call a physician.
Inhalation
Wash off immediately with soap and plenty of water while removing all contaminated clothes and shoes. If skin irritation persists, call a physician.
Remove to fresh air Call a physician If breathing is irregular or stopped, administer artificial respiration Avoid direct contact with skin. Use barrier to give mouth-to-mouth resuscitation
Immediate medical attention is not required Move to fresh air in case of accidental inhalation of vapors If symptoms persist, call a physician
Ingestion
Immediate medical attention is not required Move to fresh air in case of accidental inhalation of vapors If symptoms persist, call a physician
Rinse mouth. Drink plenty of water. If symptoms persist, call a physician. Do NOT induce vomiting. Clean mouth with water and drink afterwards plenty of water. Never give anything by mouth to an unconscious person. Call a physician.
Self-protection of the first aider
Remove all sources of ignition. Use personal protective equipment as required.
Most important symptoms and effects, both acute and delayed
SymptomsNo information available.
Indication of any immediate medical attention and special treatment needed
Note to physiciansTreat symptomatically.
Suitable Extinguishing Media
Suitable Extinguishing MediaUse extinguishing measures that are appropriate to local circumstances and the surrounding environment.
Unsuitable Extinguishing Media
None.
Specific hazards arising from the chemical
Specific hazards arising from the chemicalThermal decomposition can lead to release of toxic/corrosive gases and vapors.
Hazardous combustion products
Carbon oxides. Nitrogen oxides (NOx). Phosgene.
Explosion data
Sensitivity to Mechanical ImpactNo information available.
Sensitivity to Static Discharge
No information available.
Protective equipment and precautions for firefighters
Protective equipment and precautions for firefightersAs in any fire, wear self contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full protective gear.
NFPA 704
3
1
0
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 1 | Materials that require considerable preheating, under all ambient temperature conditions, before ignition and combustion can occur. Includes some finely divided suspended solids that do not require heating before ignition can occur. Flash point at or above 93.3 °C (200 °F). (e.g. mineral oil, ammonia) | |
| REACT | 0 | Normally stable, even under fire exposure conditions, and is not reactive with water (e.g. helium,N2) | |
| SPEC. HAZ. |
Personal precautions, protective equipment and emergency procedures
Personal precautionsRemove all sources of ignition. Evacuate personnel to safe areas. Ensure adequate ventilation, especially in confined areas. Use personal protective equipment as required.
Keep people away from and upwind of spill/leak.
Keep people away from and upwind of spill/leak.
Environmental precautions
Environmental precautionsPrevent further leakage or spillage if safe to do so. Prevent product from entering drains. Do not flush into surface water or sanitary sewer system. See Section 12 for additional
Ecological Information.
Ecological Information.
Methods and material for containment and cleaning up
Methods for containmentPrevent further leakage or spillage if safe to do so.
Methods for cleaning up
Pick up and transfer to properly labeled containers. Dam up. Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, sawdust). Soak up with inert absorbent material.
Precautions for safe handling
Advice on safe handlingEnsure adequate ventilation, especially in confined areas. Keep away from heat, sparks, flame and other sources of ignition (i.e., pilot lights, electric motors and static electricity).
Take precautionary measures against static discharges. Use spark-proof tools and explosion-proof equipment. All equipment used when handling the product must be grounded. Use with local exhaust ventilation. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection. Thermal decomposition can lead to release of toxic/corrosive gases and vapors.
Take precautionary measures against static discharges. Use spark-proof tools and explosion-proof equipment. All equipment used when handling the product must be grounded. Use with local exhaust ventilation. Use personal protective equipment as required. Do not breathe dust/fume/gas/mist/vapors/spray. Handle in accordance with good industrial hygiene and safety practice. Corrosive hazard. Wear protective gloves/clothing and eye/face protection. Thermal decomposition can lead to release of toxic/corrosive gases and vapors.
Conditions for safe storage, including any incompatibilities
Storage ConditionsKeep tightly closed in a dry and cool place. Keep in properly labeled containers. Keep containers tightly closed in a cool, well-ventilated place. Store at 4 °C.
Incompatible materials
None known based on information supplied.
Control parameters
Exposure Guidelines.
Other Information
Vacated limits revoked by the Court of Appeals decision in AFL-CIO v. OSHA, 965 F.2d 962 (11th Cir., 1992).
| Chemical Name | ACGIH TLV | OSHA PEL | NIOSH IDLH |
|---|---|---|---|
| Acetonitrile 75-05-8 | TWA: 20 ppm S* | TWA: 40 ppm TWA: 70 mg/m3 TWA: 5 mg/m3 CN (vacated) TWA: 40 ppm (vacated) TWA: 70 mg/m3 (vacated) TWA: 5 mg/m3 (vacated) STEL: 60 ppm (vacated) STEL: 105 mg/m3 S* | IDLH: 500 ppm IDLH: 25 mg/m3 CN TWA: 20 ppm TWA: 34 mg/m3 |
Appropriate engineering controls
Engineering ControlsShowers
Eyewash stations
Ventilation systems
Eyewash stations
Ventilation systems
Individual protection measures, such as personal protective equipment
Eye/face protectionTight sealing safety goggles. Face protection shield.
Skin and Body Protection
Wear protective gloves and protective clothing.
Respiratory protection
If exposure limits are exceeded or irritation is experienced, NIOSH/MSHA approved respiratory protection should be worn. Positive-pressure supplied air respirators may be required for high airborne contaminant concentrations. Respiratory protection must be provided in accordance with current local regulations.
General Hygiene Considerations
When using do not eat, drink or smoke. Regular cleaning of equipment, work area and clothing is recommended.
Information on basic physicochemical properties
- Physical Stateliquid
- AppearanceNo information available
- OdorNo information available
- pHNo information available
- Melting point/freezing pointNo information available
- Boiling point84 °C
- Flash point2 °C
- Density1.655±0.06 g/cm3(Predicted)
- Evaporation rateNo information available
- Upper flammability limitsNo information available
- Lower flammability limitNo information available
- Vapor pressureNo information available
- Vapor densityNo information available
- Specific gravityNo information available
- Water solubilityNo information available
- Solubility in other solventsNo information available
- Partition coefficientNo information available
- Autoignition temperatureNo information available
- Decomposition temperatureNo information available
- Kinematic viscosityNo information available
- Explosive propertiesNo information available
- Oxidizing propertiesNo information available
- SolubilityChloroform (Slightly), Methanol (Slightly)
- ColourOff-White to Pale Beige
Reactivity
Not applicable
Chemical stability
Stable under recommended storage conditions.
Possibility of Hazardous Reactions
None under normal processing.
Hazardous polymerization
No information available.
Conditions to avoid
Heat, flames and sparks.
Incompatible materials
Strong oxidizing agents.
Hazardous Decomposition Products
Carbon oxides. Nitrogen oxides (NOx). Phosgene.
Information on likely routes of exposure
InhalationClassified based on available data. For more details, see section 2.
Eye contact
Classified based on available data. For more details, see section 2.
Skin Contact
Classified based on available data. For more details, see section 2.
Ingestion
Classified based on available data. For more details, see section 2.
Information on toxicological effects
SymptomsClassified based on available data. For more details, see section 2.
Delayed and immediate effects as well as chronic effects from short and long-term exposure
Chronic ToxicityAvoid repeated exposure. May cause adverse liver effects. Target Organ Effects Central Vascular System (CVS), Central nervous system, Respiratory system, Kidney, Liver.
Numerical measures of toxicity - Product Information
Unknown acute toxicity12.658% of the mixture consists of ingredient(s) of unknown toxicity
The following values are calculated based on chapter 3.1 of the GHS document
ATEmix (oral)
The following values are calculated based on chapter 3.1 of the GHS document
500 mg/kg
ATEmix (dermal)
1100 mg/kg
ATEmix (inhalation-dust/mist)
1.5 mg/l
Ecotoxicity
May cause long lasting harmful effects to aquatic life
12.658% of the mixture consists of components(s) of unknown hazards to the aquatic environment.
| Chemical Name | Algae/aquatic plants | Fish | Toxicity to Microorganisms | Crustacea |
|---|---|---|---|---|
| Acetonitrile 75-05-8 | - | 1600 - 1690: 96 h Pimephales promelas mg/L LC50 flow-through 1650: 96 h Poecilia reticulata mg/L LC50 static 1850: 96 h Lepomis macrochirus mg/L LC50 static 1000: 96 h Pimephales promelas mg/L LC50 static | - | 5838: 18 h Daphnia pulex mg/L EC50 |
Acetonitrile -
1600 - 1690: 96 h - 5838: 18 h Daphnia pulex
Persistence and degradability
No information available.
Bioaccumulation
No information available.
Mobility
No information available.
Acetonitrile
-0.34 75-05-8
Disposal of wastes
Disposal should be in accordance with applicable regional, national and local laws and regulations.
Contaminated packaging
Do not reuse container.
Other Information
Waste codes should be assigned by the user based on the application for which the product was used.
US EPA Waste Number
U003
California Hazardous Waste Status
This product contains one or more substances that are listed with the State of California as a hazardous waste.
| Chemical Name | California Hazardous Waste Status |
|---|---|
| Acetonitrile 75-05-8 | Toxic Ignitable |
Acetonitrile
Toxic
DOT
UN/ID noUN1648
Hazard Class
3
Packing Group
II
Proper shipping name
Acetonitrile
Description
UN1648, Acetonitrile, 3, II, Marine pollutant Marine pollutant This product contains a chemical which is listed as a marine pollutant according to DOT
Emergency Response Guide Number
127
IMDG
UN/ID noUN1648
Hazard Class
3
Packing Group
II
Proper shipping name
Acetonitrile
Description
UN1648, Acetonitrile, 3, II, (2°C c.c.), Marine pollutant
EmS-No
F-E, S-D
IATA
UN/ID noUN1648
Hazard Class
3
Packing Group
II
Proper shipping name
Acetonitrile
Description
UN1648, Acetonitrile, 3, II
International Inventories
All of the components in the product are on the following Inventory lists
Europe (EINECS/ELINCS/NLP)
X - Listed
TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
Europe (EINECS/ELINCS/NLP)
X - Listed
TSCA - United States Toxic Substances Control Act Section 8(b) Inventory
DSL/NDSL - Canadian Domestic Substances List/Non-Domestic Substances List
EINECS/ELINCS - European Inventory of Existing Chemical Substances/European List of Notified Chemical Substances
ENCS - Japan Existing and New Chemical Substances
IECSC - China Inventory of Existing Chemical Substances
KECL - Korean Existing and Evaluated Chemical Substances
PICCS - Philippines Inventory of Chemicals and Chemical Substances
| Chemical name | TSCA | DSL | NDSL | EINECS | ELINCS | ENCS | IECSC | KECL | PICCS | AICS |
|---|---|---|---|---|---|---|---|---|---|---|
| Acetonitrile | X | X | - | X | - | X | X | X | X | X |
| 2,3,4,5-Tetrachloroaniline | - | - | - | X | - | - | - | - | - | - |
US Federal Regulations
SARA 313
Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product does not contain any chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.
SARA 311/312 Hazard Categories
Acute health hazardYes
Chronic Health Hazard
No
Fire hazard
Yes
Sudden release of pressure hazard
No
Reactive hazard
No
CWA (Clean Water Act)
This product contains the following substances which are regulated pollutants pursuant to the Clean Water Act (40 CFR 122.21 and 40 CFR 122.42).
| Chemical Name | CWA - Reportable Quantities | CWA - Toxic Pollutants | CWA - Priority Pollutants | CWA - Hazardous Substances |
|---|---|---|---|---|
| Acetonitrile 75-05-8 | X | X |
US State Regulations
California Proposition 65
This product does not contain any Proposition 65 chemicals.
U.S. State Right-to-Know Regulations
| Chemical Name | New Jersey | Massachusetts | Pennsylvania |
|---|---|---|---|
| Acetonitrile 75-05-8 | X | X | X |
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.