11.1 Information on toxicological effects
Mixture Acute toxicity
Oral: No data available
Symptoms: mucosal irritations, Cough, Shortness of breath, Possible damages:, damage of respiratory tract
Dermal: No data available
Skin corrosion/irritation
Classified based on available data. For more details, see section 2
Serious eye damage/eye irritation
Classified based on available data. For more details, see section 2
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Mixture may cause respiratory irritation.
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Endocrine disrupting properties
Product:
Assessment : The substance/mixture does not contain components considered to have endocrine disrupting properties according to REACH Article 57(f) or Commission Delegated regulation (EU) 2017/2100 or Commission Regulation (EU) 2018/605 at levels of 0.1% or higher.
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Hazardous properties cannot be excluded but are unlikely when the product is handled appropriately.
Components 2,6-Dimethylheptan-4-one
Acute toxicity
LD50 Oral - Rat - male and female - > 2.000 mg/kg (OECD Test Guideline 401)
LC50 Inhalation - Rat - 4 h - > 14,5 mg/l (OECD Test Guideline 403)
LD50 Dermal - Rat - male and female - > 2.000 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation - 4 h (OECD Test Guideline 404)
Serious eye damage/eye irritation
Eyes - Rabbit
Result: No eye irritation (OECD Test Guideline 405)
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: Does not cause skin sensitization.
(OECD Test Guideline 406)
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Test Type: Ames test
Test system: S. typhimurium
Result: negative
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
3,3,5-trimethylcyclohexanone
Acute toxicity
LD50 Oral - Rat - male and female - > 2.000 mg/kg (OECD Test Guideline 401)
Symptoms: Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract.
LC50 Inhalation - Rat - male - 4 h - 14,2 mg/l - aerosol (OECD Test Guideline 403)
Symptoms: Shortness of breath, Cough, mucosal irritations, Possible damages:, damage of respiratory tract
Inhalation: absorption
LD50 Dermal - Rat - male and female - > 2.000 mg/kg (OECD Test Guideline 402)
Skin corrosion/irritation
Skin - Rabbit
Result: No skin irritation (OECD Test Guideline 404)
Serious eye damage/eye irritation
Classified based on available data. For more details, see section 2
Respiratory or skin sensitization
Buehler Test - Guinea pig
Result: negative (OECD Test Guideline 406)
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Test Type: In vitro mammalian cell gene mutation test
Test system: Chinese hamster lung cells
Result: negative
Method: OECD Test Guideline 474
Species: Mouse - male and female
Result: negative
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
May cause respiratory irritation.
Acute oral toxicity - Irritations of mucous membranes in the mouth, pharynx, oesophagus and gastrointestinal tract.
Acute inhalation toxicity - Shortness of breath, Cough, mucosal irritations, Possible damages:, damage of respiratory tract
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2