Chemical Safety Data Sheet MSDS / SDS
4-CHLORO-2,5-DIFLUORONITROBENZENE
Revision Date:2026-05-31Revision Number:1
Product identifier
- Product name: 4-CHLORO-2,5-DIFLUORONITROBENZENE
- CBnumber: CB6139720
- CAS: 578-28-9
- Synonyms: 1-Chloro-2,5-difluoro-4-nitrobenzene,4-chloro-2,5-difluoronitrobenzene
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P405 Store locked up.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313 IF eye irritation persists: Get medical advice/attention.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P284 Wear respiratory protection.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P270 Do not eat, drink or smoke when using this product.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P501 Dispose of contents/container to..…
Hazard statements
H412 Harmful to aquatic life with long lasting effects
H335 May cause respiratory irritation
H373 May cause damage to organs through prolonged or repeated exposure
H372 Causes damage to organs through prolonged or repeated exposure
H371 May cause damage to organs
H319 Causes serious eye irritation
H315 Causes skin irritation
H302 Harmful if swallowed
H330 Fatal if inhaled
Substance
- Product name: 4-CHLORO-2,5-DIFLUORONITROBENZENE
- Synonyms: 1-Chloro-2,5-difluoro-4-nitrobenzene,4-chloro-2,5-difluoronitrobenzene
- CAS: 578-28-9
- MF: C6H2ClF2NO2
- MW: 193.54
Description of first aid measures
General advice
Consult a physician. Show this safety data sheet to the doctor in attendance.Move out of dangerous area.
If inhaled
If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician.
In case of skin contact
Wash off with soap and plenty of water. Consult a physician.
In case of eye contact
Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician.
If swallowed
Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2 or section 11)
Indication of any immediate medical attention and special treatment needed
no data available
Extinguishing media Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
Special hazards arising from the substance or mixture
Carbon oxides, nitrogen oxides (NOx), Hydrogen bromide gas
Advice for firefighters
Wear self contained breathing apparatus for fire fighting if necessary.
Further information
no data available
Personal precautions, protective equipment and emergency procedures
Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Pick up and arrange disposal without creating dust. Sweep up and shovel. Keep in suitable, closed containers for disposal.
Reference to other sections
For disposal see section 13.
Precautions for safe handling
Avoid contact with skin and eyes. Avoid formation of dust and aerosols.
Provide appropriate exhaust ventilation at places where dust is formed.
Normal measures for preventive fire protection.
For precautions see section 2.
Provide appropriate exhaust ventilation at places where dust is formed.
Normal measures for preventive fire protection.
For precautions see section 2.
Conditions for safe storage, including any incompatibilities
Keep in dry area.
Room Temperature.
Room Temperature.
Specific end use(s)
Apart from the uses mentioned in section 1, no other specific uses are stipulated
Components with workplace control parameters
Contains no substances with occupational exposure limit values.
Appropriate engineering controls
Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday.
Personal protective equipment
Eye/face protection
Face shield and safety glasses Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Skin protection
Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique (without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands.
Body Protection
Complete suit protecting against chemicals, The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace.
Respiratory protection
For nuisance exposures use type P95 (US) or type P1 (EU EN 143) particle respirator.For higher level protection use type OV/AG/P99 (US) or type ABEK-P2 (EU EN 143) respirator cartridges. Use respirators and components tested and approved under appropriate government standards such as NIOSH (US) or CEN (EU).
Control of environmental exposure
Do not let product enter drains.
Information on basic physicochemical properties
- Appearance / Formliquid
- Odorno data available
- Odor Thresholdno data available
- pHno data available
- Melting point28°C
- Boiling point/range116 °C(Press: 20 Torr)
- Flash point103.8±25.9 °C
- Evapouration rateno data available
- Flammabilityno data available
- Upper/lower flammabilityno data available
- explosive limitsno data available
- Vapor pressureno data available
- Vapour densityno data available
- Relative density1.591±0.06 g/cm3(Predicted)
- Water solubilityno data available
- Partition coefficientno data available
- Auto-ignition temperatureno data available
- Decomposition Tempno data available
- log Powno data available
- Viscosityno data available
- Explosive propertiesno data available
- Oxidizing propertiesno data available
Other safety information
no data available
Reactivity
no data available
Chemical stability
Stable under recommended storage conditions.
Possibility of hazardous reactions
no data available
Conditions to avoid
no data available
Incompatible materials
no data available
Hazardous decomposition products
no data available
Other decomposition products
no data available
In the event of fire
see section 5
Acute toxicity
Classified based on available data. For more details, see section 2
Skin corrosion/irritation
Classified based on available data. For more details, see section 2
Serious eye damage/irritation
Classified based on available data. For more details, see section 2
Respiratory or skin sensitisation
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
IARC
No component of this product present at levels greater than or equal to 0.1% is identified as probable, possible or confirmed human carcinogen by IARC.
ACGIH
No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by ACGIH.
NTP
No component of this product present at levels greater than or equal to 0.1% is identified as a known or anticipated carcinogen by NTP.
OSHA
No component of this product present at levels greater than or equal to 0.1% is identified as a carcinogen or potential carcinogen by OSHA.
Reproductive toxicity
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
Additional Information
Classified based on available data. For more details, see section 2
To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
Toxicity
no data available
Persistence and degradability
no data available
Bioaccumulative potential
no data available
Mobility in soil
no data available
Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
Other adverse effects
no data available
Waste treatment methods
Offer surplus and non-recyclable solutions to a licensed disposal company. Contact a licensed professional waste disposal service to dispose of this material.
Contaminated packaging
Dispose of as unused product.
UN number
ADR/RID:
IMDG:
IATA-DGR:
IMDG:
IATA-DGR:
UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
IMDG: Not dangerous goods
IATA: Not dangerous goods
Transport hazard class(es)
ADR/RID:
IMDG:
IATA-DGR:
IMDG:
IATA-DGR:
Packaging group
ADR/RID:
IMDG:
IATA-DGR:
IMDG:
IATA-DGR:
Environmental hazards
ADR/RID: -
IMDG: -
IATA-DGR: -
IMDG: -
IATA-DGR: -
Special precautions for user
Further information : No data available
SARA 302
No chemicals in this material are subject to the reporting requirements of SARA Title III, Section 302.
SARA 313
This material does not contain any chemical components with known CAS numbers that exceed the threshold (De Minimis) reporting levels established by SARA Title III, Section 313.
SARA 311/312 Hazards
Acute Health Hazard
Massachusetts Right To Know Components
No components are subject to the Massachusetts Right to Know Act.
Pennsylvania Right To Know Components
New Jersey Right To Know Components
California Prop. 65 Components
This product does not contain any chemicals known to State of California to cause cancer, birth defects, or any other reproductive harm.
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.
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