[CAS NO. 14901-07-6]??β-Ionone

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PRODUCTS SPECIFICATIONS [14901-07-6]

Catalog

HY-W015084

Brand

MCE

CAS

14901-07-6

DESCRIPTION [14901-07-6]

Overview

MDL	MFCD00167092
Molecular Weight	192.30
Molecular Formula	C13H20O
SMILES	CC(/C=C/C1=C(C)CCCC1(C)C)=O

For research use only. We do not sell to patients.

Summary

β-Ionone is effective in the induction of apoptosis in gastric adenocarcinoma SGC7901 cells. Anti-cancer activity ^[1] .

In Vitro

β-Ionone is an analog of β-carotenoids which widely distributed in fruit and vegetables ^[1] .
β-ionone (25, 50, 100 and 200 μM; for 24 and 48 h) inhibits SGC-7901 cell line growth. The measured IC ₅₀ value is 89 μM ^[1] .

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT03095833	Hospices Civils de Lyon	Healthy	February 27, 2015	Not Applicable

Appearance

Liquid

Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL ( 520.02 mM ; Need ultrasonic)

Ethanol : 100 mg/mL ( 520.02 mM ; Need ultrasonic)

H ₂ O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C) (insoluble)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2002 mL	26.0010 mL	52.0021 mL
5 mM	1.0400 mL	5.2002 mL	10.4004 mL
10 mM	0.5200 mL	2.6001 mL	5.2002 mL

* Please refer to the solubility information to select the appropriate solvent.

In Vivo:

1.

Add each solvent one by one: 10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline

Solubility: ≥ 2.5 mg/mL (13.00 mM); Clear solution
2.

Add each solvent one by one: 10% DMSO >> 90% (20% SBE-β-CD in saline)

Solubility: ≥ 2.5 mg/mL (13.00 mM); Clear solution
3.

Add each solvent one by one: 10% DMSO >> 90% corn oil

Solubility: ≥ 2.5 mg/mL (13.00 mM); Clear solution

* All of the co-solvents are available by MCE.

References

[1] Mahsa Ansari, et al. β-Ionone and Its Analogs as Promising Anticancer Agents. Eur J Med Chem. 2016 Nov 10;123:141-154.

Synonyms

3-Buten-2-one, 4-(2,6,6-trimethyl-1-cyclohexen-1-yl)-

4-(2,6,6-Trimethyl-1-cyclohexen-1-yl)-3-buten-2-one

4-(2,6,6-Trimethyl-1-cyclohexenyl)-3-buten-2-one

NSC 402758

NSC 46137

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