C.I. acid red 018
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- ???: 010-86108875
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0.00000000000000000000000000129 ㎜Hg (@ 25 °C)
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80000 ㎎/?
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1.63 (Log Kow)
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604.48
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????LD50 >8,000 ㎎/㎏ ??? : Rat
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Probability of MOD/SEV = 0.000
Prob. of SEV Ocular Irritancy = 0.000
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In vitro - Salmonella typhimurium/TA98, TA100 (????????): ????? ??? ???? Negative (CCRIS); TA98: ????? ??? ???? Negative, ??? ???/UDS ??: Negative In vivo - Mosue ?? ?? ?????/????: Negative
A TERATOLOGY STUDY ON PONCEAU 4R WAS CARRIED OUT IN NMRI MICE. THE MICE WERE GIVEN BY GAVAGE EITHER FROM DAY 0 THROUGH DAY 7 OR FROM DAY 6 THROUGH 18 OF GESTATION DOSES OF 7.5, 30 OR 100 MG/KG. NO EFFECT OF TREATMENT WITH THE DYE COULD BE OBSERVED WITH REGARD TO NUMBER OF IMPLANTATIONS, FREQUENCY OF FETAL DEATH RESORPTIONS, GROSS MALFORMATIONS, SKELETAL OR INTERNAL MALFORMATIONS OR RETARDED GROWTH AS JUDGED BY FETAL WEIGHT. ???, ????? ??, ??, ?? ?? ???? ?? ?? ? ????? ????. No treatment-related effects were seen in the uterine contents of females at any generation, but the skeletons of treated fetuses showed a slightly more advanced development than those of the controls. It is concluded that the no-adverse-effect level for Ponceau 4R is 120 mg/kg body weight/day Rat(inhalation);1.8mg/m3(male 76D prior to mating) Effects on Fertility - Post-implantation mortality (e.g., dead and or resorbed implants per total number of implants)????? Effects on Newborn - Live birth index (similar to T26, except measured after birth) Effects on Newborn - Sex ratio ??? ?? Mouse(oral);73.54gm/kg(female multigeneration) Effects on Newborn - Behavioral ???? Mammal(inhalation);8.3mg/m3(female 1-7D of pregnancy) Effects on Fertility - Post-implantation mortality (e.g., dead and or resorbed implants per total number of implants)????? Effects on Embryo or Fetus - Fetal death???? ??
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??LC50 35.964 ㎎/? 96 hr (ECOSAR Class : Hydrazines-acid)
LC50 214.169 ㎎/? 48 hr (ECOSAR Class : Hydrazines-acid)
EC50 0.00101 ㎎/? 96 hr (ECOSAR Class : Hydrazines-acid)
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???1.63 log Kow
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(Cut-off value = -0.723 ; ????(BIOWIN 5))
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265.8
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