Chemical Safety Data Sheet MSDS / SDS
Methylene Blue trihydrate
Revision Date:2026-05-31Revision Number:1
Product identifier
- Product name: Methylene Blue trihydrate
- CBnumber: CB3748860
- CAS: 7220-79-3
- EINECS Number: 615-731-6
- Synonyms: Methylene Blue trihydrate,methylthioninium
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordWarning
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P501 Dispose of contents/container to..…
Hazard statements
H302 Harmful if swallowed
Substance
- Product name: Methylene Blue trihydrate
- Synonyms: Methylene Blue trihydrate,methylthioninium
- CAS: 7220-79-3
- EC number: 615-731-6
- MF: C16H20ClN3OS
- MW: 337.87
General advice
Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower.
In case of eye contact
After eye contact: rinse out with plenty of water. Remove contact lenses.
If swallowed
After swallowing: immediately make victim drink water (two glasses at most). Consult a physician.
Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
Protection of first-aiders
For personal protection see section 8.
Notes to physician
No data available
Suitable extinguishing media
Water Foam Carbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
For this substance/mixture no limitations of extinguishing agents are given.
Specific hazards during fire fighting
Combustible. Fire may cause evolution of: Sulfur oxides nitrogen oxides Hydrogen chloride gas Development of hazardous combustion gases or vapours possible in the event of fire.
Hazardous combustion products
Carbon oxides Nitrogen oxides (NOx) Sulfur oxides Hydrogen chloride gas
Specific extinguishing methods
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Special protective equipment for fire-fighters
In the event of fire, wear self-contained breathing apparatus.
Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert. Advice for emergency responders: For personal protection see section 8.
Environmental precautions
Do not let product enter drains.
Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid generation of dusts.
Handling
For precautions see section 2.2.
Storage
Further information on storage conditionsTightly closed. Dry.
Storage class
11, Combustible Solids
Recommended storage temperature
2 - 30 °C
Ingredients with workplace control parameters
Contains no substances with occupational exposure limit values.
Engineering measures
No data available
Personal protective equipment
Respiratory protectionrequired when dusts are generated.
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Recommended Filter type
Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Filter type P2
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Eye/face protection
The entrepeneur has to ensure that maintenance, cleaning and testing of respiratory protective devices are carried out according to the instructions of the producer. These measures have to be properly documented.
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU).
Safety glasses
Skin and body protection
Safety glasses
protective clothing
Hand protection
Material
Nitrile rubber
Break through time
480 min
Glove thickness
0.11 mm
Protective index
Full contact
Manufacturer
KCL 741 L
Material
Nitrile rubber
Break through time
480 min
Glove thickness
0.11 mm
Protective index
Splash contact
Manufacturer
KCL 741 L
Remarks
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D- 36124 Eichenzell, Internet: www.kcl.de).
Hygiene measures
Change contaminated clothing. Preventive skin protection recommended. Wash hands after working with substance.
Information on basic physicochemical properties
- Physical stateSolid
- SolubilitySoluble in water, chloroform; sparingly soluble in ethanol
- Bulk densityca. 400 - 600 kg/m3
- Particle characteristics Particle sizeNo data available
- Molecular weight373.9 g/mol
- Oxidizing propertiesnone
- Explosive propertiesNot classified as explosive.
- Flow timeNo data available
- Viscosity, kinematicNo data available
- Viscosity, dynamicNo data available
- Decomposition temperatureNo data available
- Partition coefficient: n-octanol/waterlog Pow: 5.85
Method: (calculated) (Lit.) Potential bioaccumulation Autoignition temperature: No data available - Water solubilityca. 50 g/l (20 °C)
- Density0.98 g/mL at 25 °C
- Relative density0.98 g/mL at 25 °C
- Relative vapor densityNo data available
- Vapor pressureNo data available
- Lower explosion limit / Lower flammability limitNo data available
- Upper explosion limit / Upper flammability limitNo data available
- Burning rateNo data available
- Flammability (liquids)No data available
- Flammability (solid, gas)No data available
- Evaporation rateNo data available
- Flash point14 °C
- Boiling point/boiling rangeNo data available
- Melting point/ rangeca. 180 °C (decomposition)
- pHca. 3 (20 °C)
Concentration: 10 g/l - Odor ThresholdNot applicable
- Odorodorless
- Colordark blue
- Appearancesolid
Reactivity
The following applies in general to flammable organic substances and mixtures: in correspondingly fine distribution, when whirled up a dust explosion potential may generally be assumed.
Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
Possibility of hazardous reactions
Violent reactions possible with: Strong oxidizing agents Bases Reducing agents alkali compounds iodides potassium dichromate
Conditions to avoid
Strong heating (decomposition). no information available
Incompatible materials
No data available
Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - 1,180 mg/kg
Oral: Harmful if swallowed.
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Oral: Harmful if swallowed.
Inhalation: No data available
Dermal: No data available
Remarks: No data available
Serious eye damage/eye irritation
Remarks: No data available
Respiratory or skin sensitization
Classified based on available data. For more details, see section 2
Germ cell mutagenicity
Classified based on available data. For more details, see section 2
Carcinogenicity
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
Classified based on available data. For more details, see section 2
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Absorption into the body leads to the formation of methemoglobin which in suffi- cient concentration causes cyanosis. Onset may be delayed 2 to 4 hours or longer.,
Vomiting, Diarrhea, To the best of our knowledge, the chemical, physical, and toxi- cological properties have not been thoroughly investigated.
Vomiting, Diarrhea, To the best of our knowledge, the chemical, physical, and toxi- cological properties have not been thoroughly investigated.
Ecotoxicity
Toxicity to fishLC50 (Pimephales promelas (fathead minnow)): 45 mg/l Exposure time: 96 h Remarks: (anhydrous substance) (ECOTOX Database)
Toxicity to daphnia and other aquatic invertebrates
EC50 (Daphnia magna (Water flea)): 2,260 mg/l Exposure time: 48 h Remarks: (anhydrous substance) (ECOTOX Database)
Components:
Methylthioninium chloride:
Toxicity to fishRemarks: No data available
Persistence and degradability
Components:
Methylthioninium chloride:
BiodegradabilityRemarks: No data available
Bioaccumulative potential
Components:
Methylthioninium chloride:
BioaccumulationRemarks: No data available
Mobility in soil
Components:
Methylthioninium chloride:
Stability in soilRemarks: No data available
Other adverse effects
Additional ecological informationDischarge into the environment must be avoided.
Components:
Methylthioninium chloride:
Additional ecological informationNo data available
Disposal methods
Waste from residuesOffer surplus and non-recyclable solutions to a licensed disposal company.
International Regulations
IATA-DGR
UN/ID No. : Not applicable
Proper shipping name : Not applicable
Class : Not applicable
Subsidiary risk : Not applicable
Packing group : Not applicable
Labels : Not applicable
Packing instruction (cargo aircraft) : Not applicable
Packing instruction (passenger aircraft) : Not applicable
Proper shipping name : Not applicable
Class : Not applicable
Subsidiary risk : Not applicable
Packing group : Not applicable
Labels : Not applicable
Packing instruction (cargo aircraft) : Not applicable
Packing instruction (passenger aircraft) : Not applicable
IMDG-Code
UN number : Not applicable
Proper shipping name : Not applicable
Class : Not applicable
Subsidiary risk : Not applicable
Packing group : Not applicable
Labels : Not applicable
EmS Code : Not applicable
Marine pollutant : no
Proper shipping name : Not applicable
Class : Not applicable
Subsidiary risk : Not applicable
Packing group : Not applicable
Labels : Not applicable
EmS Code : Not applicable
Marine pollutant : no
Transport in bulk according to Annex II of MARPOL 73/78 and the IBC Code
Not applicable for product as supplied.
National regulation
National regulation
JT/T 617
UN number : Not applicable
Proper shipping name : Not applicable
Class : Not applicable
Subsidiary risk : Not applicable
Packing group : Not applicable
Labels : Not applicable
Environmentally hazardous : no
Proper shipping name : Not applicable
Class : Not applicable
Subsidiary risk : Not applicable
Packing group : Not applicable
Labels : Not applicable
Environmentally hazardous : no
Special precautions for user
Remarks : Not classified as dangerous in the meaning of transport regulations.
Catalogue of Hazardous Chemicals : This product is not listed in the catalogue of hazardous chemicals and it does not meet the definition of hazardous chemicals and its principles of determination.
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
Downstream users need to comply with the conditions of safe use of the chemical, understand the environmental and health hazard and risk management measures identified on the SDS as well as the local/national regulations concerning the chemical.
National regulatory information
Regulations on Safety Management of Hazardous Chemicals
Identification of Major Hazard Installations for Hazardous Chemicals (GB 18218)
Not listed
Hazardous Chemicals for Priority Management
Not listed under SAWS
Catalogue of Specially Controlled Hazardous
Not listed Chemicals
List of Explosive Precursors
Not listed
Regulations on Occupational Labor Protection in the at workplaces where
Toxic Substances Are Used
Catalogue of Highly Toxic Chemicals
Not listed
Regulation of Environmental Management on the First Import of Chemicals and the Import and Export of Toxic Chemicals
China Severely Restricted Toxic Chemicals for Import and Export
Not listed
Measures on the Environmental Administration of New Chemical Substances Registration
Registration/Notification number
B1A122214038 B1A222223342
Regulation on the Administration of Precursor Chemicals
Catalogue and Classification of Precursor Chemicals
Not listed
Regulations on the Administration of Controlled Chemicals
List of Controlled Chemicals
Not listed
Regulations of Ozone Depleting Substances Management
List of Controlled Ozone Depleting Substances
Not listed
List of Controlled Ozone Depleting Substances Import and Export
Not listed
Environmental Protection Law
List of Priority Controlled Chemicals
Not listed
List of Key Controlled New Pollutants
Not listed
Full text of other abbreviations
AIIC - Australian Inventory of Industrial Chemicals
ANTT - National Agency forTransport by Land of Brazil
ASTM - American Society for the Testing of Materials
bw - Body weight
CMR - Carcinogen, Mutagen or Reproductive Toxicant
DIN -Standard of the German Institute for Standardisation
DSL - Domestic SubstancesList (Canada)
ECx - Concentration associated with x% response
ELx - Loading rate associated with x% response
EmS - Emergency Schedule
ENCS - Existing and NewChemical Substances (Japan)
ErCx - Concentration associated with x% growth rate response
ERG - Emergency Response Guide
GHS - Globally Harmonized System
GLP - Good Laboratory Practice
IARC - International Agency for Research on Can- cer
IATA - International Air Transport Association
IBC - International Code for theConstruction and Equipment of Ships carrying Dangerous Chemicals in Bulk
IC50 -Half maximal inhibitory concentration
ICAO - International Civil Aviation Organiza- tion
IECSC - Inventory of Existing Chemical Substances in China
IMDG - Interna- tional Maritime Dangerous Goods
IMO - International Maritime Organization
ISHL -Industrial Safety and Health Law (Japan)
ISO - International Organisation forStandardization
KECI - Korea Existing Chemicals Inventory
LC50 - Lethal Concen- tration to 50 % of a test population
LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose)
MARPOL - International Convention for the Prevention of Pol- lution from Ships
n.o.s. - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC -No Observed (Adverse) Effect Concentration
NO(A)EL - No Observed (Adverse) Ef- fect Level
NOELR - No Observable Effect Loading Rate
NOM - Official MexicanNorm
NTP - National Toxicology Program
NZIoC - New Zealand Inventory of Chem- icals
OECD - Organization for Economic Co-operation and Development
OPPTS - Of- fice of Chemical Safety and Pollution Prevention
PBT - Persistent, Bioaccumulative and Toxic substance
PICCS - Philippines Inventory of Chemicals and Chemical Sub- stances
(Q)SAR - (Quantitative) Structure Activity Relationship
REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning theRegistration, Evaluation, Authorisation and Restriction of Chemicals
SADT - Self-Accelerating Decomposition Temperature
SDS - Safety Data Sheet
TCSI - TaiwanChemical Substance Inventory
TDG - Transportation of Dangerous Goods
TECI -Thailand Existing Chemicals Inventory
TSCA - Toxic Substances Control Act (UnitedStates)
UN - United Nations
UNRTDG - United Nations Recommendations on theTransport of Dangerous Goods
vPvB - Very Persistent and Very Bioaccumulative
WHMIS - Workplace Hazardous Materials Information System
ANTT - National Agency forTransport by Land of Brazil
ASTM - American Society for the Testing of Materials
bw - Body weight
CMR - Carcinogen, Mutagen or Reproductive Toxicant
DIN -Standard of the German Institute for Standardisation
DSL - Domestic SubstancesList (Canada)
ECx - Concentration associated with x% response
ELx - Loading rate associated with x% response
EmS - Emergency Schedule
ENCS - Existing and NewChemical Substances (Japan)
ErCx - Concentration associated with x% growth rate response
ERG - Emergency Response Guide
GHS - Globally Harmonized System
GLP - Good Laboratory Practice
IARC - International Agency for Research on Can- cer
IATA - International Air Transport Association
IBC - International Code for theConstruction and Equipment of Ships carrying Dangerous Chemicals in Bulk
IC50 -Half maximal inhibitory concentration
ICAO - International Civil Aviation Organiza- tion
IECSC - Inventory of Existing Chemical Substances in China
IMDG - Interna- tional Maritime Dangerous Goods
IMO - International Maritime Organization
ISHL -Industrial Safety and Health Law (Japan)
ISO - International Organisation forStandardization
KECI - Korea Existing Chemicals Inventory
LC50 - Lethal Concen- tration to 50 % of a test population
LD50 - Lethal Dose to 50% of a test population (Median Lethal Dose)
MARPOL - International Convention for the Prevention of Pol- lution from Ships
n.o.s. - Not Otherwise Specified
Nch - Chilean Norm
NO(A)EC -No Observed (Adverse) Effect Concentration
NO(A)EL - No Observed (Adverse) Ef- fect Level
NOELR - No Observable Effect Loading Rate
NOM - Official MexicanNorm
NTP - National Toxicology Program
NZIoC - New Zealand Inventory of Chem- icals
OECD - Organization for Economic Co-operation and Development
OPPTS - Of- fice of Chemical Safety and Pollution Prevention
PBT - Persistent, Bioaccumulative and Toxic substance
PICCS - Philippines Inventory of Chemicals and Chemical Sub- stances
(Q)SAR - (Quantitative) Structure Activity Relationship
REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the Council concerning theRegistration, Evaluation, Authorisation and Restriction of Chemicals
SADT - Self-Accelerating Decomposition Temperature
SDS - Safety Data Sheet
TCSI - TaiwanChemical Substance Inventory
TDG - Transportation of Dangerous Goods
TECI -Thailand Existing Chemicals Inventory
TSCA - Toxic Substances Control Act (UnitedStates)
UN - United Nations
UNRTDG - United Nations Recommendations on theTransport of Dangerous Goods
vPvB - Very Persistent and Very Bioaccumulative
WHMIS - Workplace Hazardous Materials Information System
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.