Chemical Safety Data Sheet MSDS / SDS
Trifluoromethanesulfonic acid
Revision Date:2026-06-27Revision Number:1
Product identifier
- Product name: Trifluoromethanesulfonic acid
- CBnumber: CB7247316
- CAS: 1493-13-6
- EINECS Number: 216-087-5
- Synonyms: TfOH,trifluoromethanesulfonic acid
Relevant identified uses of the substance or mixture and uses advised against
- Relevant identified uses: For R&D use only. Not for medicinal, household or other use.
- Uses advised against: none
Company Identification
- Company: Chemicalbook
- Address: Building 1, Huihuang International, Shangdi 10th Street, Haidian District, Beijing
- Telephone: 010-86108875
GHS Label elements, including precautionary statements
-
Symbol(GHS)
- Signal wordDanger
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P234 Keep only in original container.
Hazard statements
H335 May cause respiratory irritation
H314 Causes severe skin burns and eye damage
H302 Harmful if swallowed
H290 May be corrosive to metals
Substance
- Product name: Trifluoromethanesulfonic acid
- Synonyms: TfOH,trifluoromethanesulfonic acid
- CAS: 1493-13-6
- EC number: 216-087-5
- MF: CHF3O3S
- MW: 150.08
4.1 Description of first-aid measures
General adviceFirst aiders need to protect themselves. Show this material safety data sheet to the doctor in attendance.
If inhaled
After inhalation: fresh air. Call in physician.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with water/ shower. Call a physician immediately.
In case of eye contact
After eye contact: rinse out with plenty of water. Immediately call in ophthalmologist.
Remove contact lenses.
If swallowed
Remove contact lenses.
After swallowing: make victim drink water (two glasses at most), avoid vomiting (risk of perforation). Pulmonary failure possible after aspiration of vomit. Call a physician immediately. Do not attempt to neutralise.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section 2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available
4.4 Notes to physician
No data available
5.1 Extinguishing media
Suitable extinguishing mediaCarbon dioxide (CO2) Dry powder
Unsuitable extinguishing media
Foam Water
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Sulfur oxides
Hydrogen fluoride
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
Sulfur oxides
Hydrogen fluoride
Combustible.
Vapors are heavier than air and may spread along floors.
Forms explosive mixtures with air on intense heating.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
Stay in danger area only with self-contained breathing apparatus. Prevent skin contact by keeping a safe distance or by wearing suitable protective clothing.
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
Suppress (knock down) gases/vapors/mists with a water spray jet. Prevent fire extinguishing water from contaminating surface water or the ground water system.
NFPA 704
3
0
1
| HEALTH | 3 | Short exposure could cause serious temporary or moderate residual injury (e.g. liquid hydrogen, sulfuric acid, calcium hypochlorite, hexafluorosilicic acid) | |
| FIRE | 0 | Materials that will not burn under typical fire conditions, including intrinsically noncombustible materials such as concrete, stone, and sand. Materials that will not burn in air when exposed to a temperature of 820 °C (1,500 °F) for a period of 5 minutes.(e.g. Carbon tetrachloride) | |
| REACT | 1 | Normally stable, but can become unstable at elevated temperatures and pressures (e.g. propene) | |
| SPEC. HAZ. |
6.1 Personal precautions, protective equipment and emergency procedures
Advice for non-emergency personnel: Do not breathe vapors, aerosols. Avoid substance contact. Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures, consult an expert.
For personal protection see section 8.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see sections 7 and 10). Take up with liquid-absorbent and neutralising material (e.g.
Chemizorb? H?, Merck Art. No. 101595). Dispose of properly. Clean up affected area.
Chemizorb? H?, Merck Art. No. 101595). Dispose of properly. Clean up affected area.
6.4 Reference to other sections
For disposal see section 13.
7.1 Precautions for safe handling
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilities
Storage conditionsNo metal containers.
Tightly closed.
Store under inert gas.
Storage class
Tightly closed.
Store under inert gas.
Storage class (TRGS 510): 8A: Combustible, corrosive hazardous materials
8.1 Control parameters
Ingredients with workplace control parametersContains no substances with occupational exposure limit values.
8.2 Exposure controls
Appropriate engineering controlsImmediately change contaminated clothing. Apply preventive skin protection. Wash hands and face after working with substance.
Personal protective equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles
Skin protection
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: Viton?
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Vitoject? (KCL 890 / Aldrich Z677698, Size M)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.4 mm
Break through time: 30 min
Material tested:Camatril? (KCL 730 / Aldrich Z677442, Size M)
Body Protection
Internet: www.kcl.de).
Full contact
Material: Viton?
Minimum layer thickness: 0.7 mm
Break through time: 480 min
Material tested:Vitoject? (KCL 890 / Aldrich Z677698, Size M)
This recommendation applies only to the product stated in the safety data sheet, supplied by us and for the designated use. When dissolving in or mixing with other substances and under conditions deviating from those stated in EN 16523-1 please contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0.4 mm
Break through time: 30 min
Material tested:Camatril? (KCL 730 / Aldrich Z677442, Size M)
Acid-resistant protective clothing
Respiratory protection
required when vapours/aerosols are generated. Our recommendations on filtering respiratory protection are based on the following standards: DIN EN 143, DIN 14387 and other accompanying standards relating to the used respiratory protection system.
Control of environmental exposure
Do not let product enter drains.
Information on basic physicochemical properties
- a) Physical stateliquid
- b) Colorlight yellow
- c) Odorpungent
- d) Melting point/freezing pointMelting point: -40 °C
- e) Initial boiling point and boiling range162 °C
- f) Flammability (solid, gas)No data available
- g) Upper/lower flammability or explosive limitsNo data available
- h) Flash point> 166.7 °C - Pensky-Martens closed cup - Regulation (EC) No.
440/2008, Annex, A.9 - i) Autoignition temperatureNo data available
- j) Decomposition temperatureNo data available
- k) pH0.11
- l) ViscosityViscosity, kinematic: 1.227 - 1.251 mm2/s at 40 °C - OECD Test
Guideline 1141.864 - 1.881 mm2/s at 20 °C - OECD Test
Guideline 114
Viscosity, dynamic: 3.169 - 3.197 mPa.s at 20 °C - OECD Test
Guideline 1142.086 - 2.127 mPa.s at 40 °C - OECD Test
Guideline 114 - m) Water solubility1,600 g/l at 20 °C - OECD Test Guideline 105- soluble
- n) Partition coefficient n-octanol/waterlog Pow: < 0.3 at 25 °C - Bioaccumulation is not expected.
- o) Vapor pressure3.2 hPa at 25 °C
- p) Density1.696 g/mL at 25 °C
- Relative density1.696 g/mL at 25 °C (lit.)
- q) Relative vapor density5.2 (vs air)
- r) Particle characteristicsNo data available
- s) Explosive propertiesNo data available
- t) Oxidizing propertiesnone
- SolubilityMiscible in H<sub>2</sub>O
9.2 Other safety information
No data available
10.1 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.2 Possibility of hazardous reactions
Violent reactions possible with:
Strong oxidizing agents bases
Exothermic reaction with:
Water
Strong oxidizing agents bases
Exothermic reaction with:
Water
10.3 Conditions to avoid
Exposure to moisture.
Strong heating.
Strong heating.
10.4 Incompatible materials
Metals, Strong oxidizing agents
10.5 Hazardous decomposition products
In the event of fire: see section 5
11.1 Information on toxicological effects
Acute toxicityLD50 Oral - Rat - male - 1,605.3 mg/kg (OECD Test Guideline 401)
Inhalation: No data available
Dermal: No data available
Skin corrosion/irritation
Inhalation: No data available
Dermal: No data available
Skin - Rabbit
Result: Corrosive (OECD Test Guideline 404)
Serious eye damage/eye irritation
Result: Corrosive (OECD Test Guideline 404)
Remarks: Causes serious eye damage.
Respiratory or skin sensitization
Maximization Test - Guinea pig
Result: Did not cause sensitization on laboratory animals.
(OECD Test Guideline 406)
Germ cell mutagenicity
Result: Did not cause sensitization on laboratory animals.
(OECD Test Guideline 406)
Test Type: In vitro mammalian cell gene mutation test
Test system: mouse lymphoma cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Carcinogenicity
Test system: mouse lymphoma cells
Metabolic activation: with and without metabolic activation
Method: OECD Test Guideline 476
Result: negative
Classified based on available data. For more details, see section 2
Reproductive toxicity
Classified based on available data. For more details, see section 2
Specific target organ toxicity - single exposure
May cause respiratory irritation.
Specific target organ toxicity - repeated exposure
Classified based on available data. For more details, see section 2
Aspiration hazard
Classified based on available data. For more details, see section 2
11.2 Additional Information
Repeated dose toxicity - Rat - male and female - Oral - NOAEL (No observed adverse effect level) - 1,000 mg/kg burning sensation, Cough, wheezing, laryngitis, Shortness of breath, spasm, inflammation and edema of the larynx, spasm, inflammation and edema of the bronchi, pneumonitis, pulmonary edema, Material is extremely destructive to tissue of the mucous membranes and upper respiratory tract, eyes, and skin., To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.
12.1 Toxicity
Toxicity to fish static test LC50 - Oncorhynchus mykiss (rainbow trout) - > 100 mg/l - 96 h (OECD Test Guideline 203)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h and other aquatic (OECD Test Guideline 202) invertebrates
Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata - 48 mg/l - 72 h (OECD Test Guideline 201) static test NOEC - Pseudokirchneriella subcapitata - 5.7 mg/l - 72 h (OECD Test Guideline 201)
Toxicity to bacteria static test EC50 - activated sludge - > 1,000 mg/l - 3 h (OECD Test Guideline 209)
Toxicity to daphnia semi-static test NOEC - Daphnia magna (Water flea) - >= 100 mg/l and other aquatic - 21 d invertebrates(Chronic (OECD Test Guideline 211) toxicity)
Toxicity to daphnia static test EC50 - Daphnia magna (Water flea) - > 100 mg/l - 48 h and other aquatic (OECD Test Guideline 202) invertebrates
Toxicity to algae static test ErC50 - Pseudokirchneriella subcapitata - 48 mg/l - 72 h (OECD Test Guideline 201) static test NOEC - Pseudokirchneriella subcapitata - 5.7 mg/l - 72 h (OECD Test Guideline 201)
Toxicity to bacteria static test EC50 - activated sludge - > 1,000 mg/l - 3 h (OECD Test Guideline 209)
Toxicity to daphnia semi-static test NOEC - Daphnia magna (Water flea) - >= 100 mg/l and other aquatic - 21 d invertebrates(Chronic (OECD Test Guideline 211) toxicity)
12.2 Persistence and degradability
Biodegradability aerobic - Exposure time 28 d
Result: 0 % - Not readily biodegradable.
(OECD Test Guideline 301D)
Result: 0 % - Not readily biodegradable.
(OECD Test Guideline 301D)
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
PBT/vPvB assessment not available as chemical safety assessment not required/not conducted
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
No data available
13.1 Waste treatment methods
Product
Offer surplus and non-recyclable solutions to a licensed disposal company.
Offer surplus and non-recyclable solutions to a licensed disposal company.
14.1 UN number
ADR/RID: 3265
IMDG: 3265
IATA-DGR: 3265
IMDG: 3265
IATA-DGR: 3265
14.2 UN proper shipping name
ADR/RID: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S. (trifluoromethanesulphonic acid)
IMDG: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S. (trifluoromethanesulphonic acid)
IATA-DGR: Corrosive liquid, acidic, organic, n.o.s. (trifluoromethanesulphonic acid)
IMDG: CORROSIVE LIQUID, ACIDIC, ORGANIC, N.O.S. (trifluoromethanesulphonic acid)
IATA-DGR: Corrosive liquid, acidic, organic, n.o.s. (trifluoromethanesulphonic acid)
14.3 Transport hazard class(es)
ADR/RID: 8
IMDG: 8
IATA-DGR: 8
IMDG: 8
IATA-DGR: 8
14.4 Packaging group
ADR/RID: II
IMDG: II
IATA-DGR: II
IMDG: II
IATA-DGR: II
14.5 Environmental hazards
ADR/RID: no
IMDG Marine pollutant: no
IATA-DGR: no
IMDG Marine pollutant: no
IATA-DGR: no
14.6 Special precautions for user
Based on chemical properties, choose appropriate tools and conditions of transport.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
Transporting tools shall be equipped with appropriate and sufficient firefighting equipment and emergency leaking installations. If transporting by road, please go along the specified route.
14.7 Incompatible materials
Metals, Strong oxidizing agents
15.1 Safety, health and environmental regulations/legislation specific for the substance or mixture
National regulatory information
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Other regulations
Please pay attention on the waste treatment should also comply with local regulations requirement.
Abbreviations and acronyms
CAS: Chemical Abstracts Service
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
TWA: Time-Weighted Average
STEL: Short-Term Exposure Limit
LD50: Lethal Dose 50%
LC50: Lethal Concentration 50%
EC50: Effective Concentration 50%
PEL: Permissible Exposure Limit
TLV: Threshold Limit Value
IMDG: International Maritime Dangerous Goods Code
IATA: International Air Transport Association
ADR: European Agreement concerning the International Carriage of Dangerous Goods by Road
DOT: US Department of Transportation
NFPA: National Fire Protection Association
NIOSH: National Institute for Occupational Safety and Health
OSHA: Occupational Safety and Health Administration
Disclaimer:
The information in this MSDS is only applicable to the specified product, unless otherwise specified, it is not applicable to the mixture of this product and other substances. This MSDS only provides information on the safety of the product for those who have received the appropriate professional training for the user of the product. Users of this MSDS must make independent judgments on the applicability of this SDS. The authors of this MSDS will not be held responsible for any harm caused by the use of this MSDS.
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