1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
![1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid price.](/CAS/GIF/1160514-60-2.gif)
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- $32 - $13597.5
- Product name: 1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid
- CAS: 1160514-60-2
- MF: C16H11Cl3F3N3O3
- MW: 456.63
- EINECS:
- MDL Number:MFCD00178741
- Synonyms:1-[4-[(2,3,3-Trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-1H-pyrazole-4-carboxylicacid;Ethyl-1-(4-(2,3,3-trichloroacrylamide)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate;TRPC3 Channel Inhibitor, Pyr3 ;1-[4-(2,3,3-Trichloro-acryloylamino)-phenyl]-5-trifluoromethyl-1H-pyrazole-4-carboxylic acid ethyl ester;TRPC3 Channel Inhibitor, Pyr3 - CAS 1160514-60-2 - Calbiochem;1H-Pyrazole-4-carboxylic acid, 1-[4-[(2,3,3-trichloro-1-oxo-2-propen-1-yl)amino]phenyl]-5-(trifluoromethyl)-, ethyl ester;Pyr3;Pyr3,Pyr-3
52 prices
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Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- AvaChem
- Biosynth
- Cayman Chemical
- ChemScene
- Medical Isotopes, Inc.
- Sigma-Aldrich
- Tocris
- TRC
- Usbiological
Package
- 50
- 1mg
- 2mg
- 10
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250MG
- 500MG
- Manufactureraablocks
- Product numberAA000BE7
- Product descriptionEthyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate ≥98%
- Packaging1mg
- Price$36
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000BE7
- Product descriptionEthyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- Packaging2mg
- Price$56
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000BE7
- Product descriptionEthyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- Packaging5mg
- Price$76
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000BE7
- Product descriptionEthyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- Packaging10mg
- Price$99
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000BE7
- Product descriptionEthyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- Packaging25mg
- Price$201
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000BE7
- Product descriptionEthyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- Packaging50mg
- Price$326
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000BE7
- Product descriptionEthyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate
- Packaging100mg
- Price$451
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberY226814
- Product descriptionPyr3 97.00%
- Packaging100MG
- Price$645
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY226814
- Product descriptionPyr3 97.00%
- Packaging25MG
- Price$250
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number2175DN
- Product descriptionEthyl1-[4-(2,3,3-trichloroprop-2-enoylamino)phenyl]-5-(trifluoromethyl)pyrazole-4-carboxylate
- Packaging10mg
- Price$286
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001009
- Product descriptionPYR3 95.00%
- Packaging1MG
- Price$135.45
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001009
- Product descriptionPYR3 95.00%
- Packaging10MG
- Price$709.46
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001009
- Product descriptionPYR3 95.00%
- Packaging50MG
- Price$1230.95
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001009
- Product descriptionPYR3 95.00%
- Packaging250MG
- Price$6982.5
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberINB0001009
- Product descriptionPYR3 95.00%
- Packaging500MG
- Price$13597.5
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberB7494
- Product descriptionPyr3
- Packaging5mg
- Price$130
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA000BE7 | Ethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate ≥98% | 1mg | $36 | 2026-05-25 | Buy |
| aablocks | AA000BE7 | Ethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate | 2mg | $56 | 2026-05-25 | Buy |
| aablocks | AA000BE7 | Ethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate | 5mg | $76 | 2026-05-25 | Buy |
| aablocks | AA000BE7 | Ethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate | 10mg | $99 | 2026-05-25 | Buy |
| aablocks | AA000BE7 | Ethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate | 25mg | $201 | 2026-05-25 | Buy |
| aablocks | AA000BE7 | Ethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate | 50mg | $326 | 2026-05-25 | Buy |
| aablocks | AA000BE7 | Ethyl 1-(4-(2,3,3-trichloroacrylamido)phenyl)-5-(trifluoromethyl)-1H-pyrazole-4-carboxylate | 100mg | $451 | 2026-05-25 | Buy |
| ACHEMBLOCK | Y226814 | Pyr3 97.00% | 100MG | $645 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y226814 | Pyr3 97.00% | 25MG | $250 | 2026-05-27 | Buy |
| AK Scientific | 2175DN | Ethyl1-[4-(2,3,3-trichloroprop-2-enoylamino)phenyl]-5-(trifluoromethyl)pyrazole-4-carboxylate | 10mg | $286 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001009 | PYR3 95.00% | 1MG | $135.45 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001009 | PYR3 95.00% | 10MG | $709.46 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001009 | PYR3 95.00% | 50MG | $1230.95 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001009 | PYR3 95.00% | 250MG | $6982.5 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | INB0001009 | PYR3 95.00% | 500MG | $13597.5 | 2021-12-16 | Buy |
| ApexBio Technology | B7494 | Pyr3 | 5mg | $130 | 2021-12-16 | Buy |
Properties
Melting point :151-153 °C(Solv: toluene (108-88-3))
Boiling point :534.0±50.0 °C(Predicted)
Density :1.54±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO (up to 40 mg/ml).
form :powder
pka :9.97±0.70(Predicted)
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C16H11Cl3F3N3O3/c1-2-28-15(27)10-7-23-25(12(10)16(20,21)22)9-5-3-8(4-6-9)24-14(26)11(17)13(18)19/h3-7H,2H2,1H3,(H,24,26)
InChIKey :RZHGONNSASQOAY-UHFFFAOYSA-N
SMILES :FC(F)(F)c1[n](ncc1C(=O)OCC)c2ccc(cc2)NC(=O)C(=C(Cl)Cl)Cl
Boiling point :534.0±50.0 °C(Predicted)
Density :1.54±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :Soluble in DMSO (up to 40 mg/ml).
form :powder
pka :9.97±0.70(Predicted)
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChI :1S/C16H11Cl3F3N3O3/c1-2-28-15(27)10-7-23-25(12(10)16(20,21)22)9-5-3-8(4-6-9)24-14(26)11(17)13(18)19/h3-7H,2H2,1H3,(H,24,26)
InChIKey :RZHGONNSASQOAY-UHFFFAOYSA-N
SMILES :FC(F)(F)c1[n](ncc1C(=O)OCC)c2ccc(cc2)NC(=O)C(=C(Cl)Cl)Cl
Safety Information
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Description
Pyr3 is a pyrazole compound that selectively antagonizes the transient receptor potential canonical channel 3 (TRPC3). It inhibits TRPC3-mediated Ca2+ influx with an IC50 value of 0.7 μM without effect on other TRPC members and suppresses activation of nuclear factor of activated T cells with an IC50 value of 0.05 μM. Pyr3 has been shown to suppress cardiac hypertrophy in mice at 0.1 mg/kg/day.Related product price
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