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ChemicalBook >> CAS DataBase List >> N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide

N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide

$48 - $697
Product name: N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide
CAS: 1211565-08-0
MF: C22H26F3N3O2
MW: 421.46
EINECS:
MDL Number:MFCD18827464
Synonyms:N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide;3-[[(1R,2R)-2-(1-piperidinyl)cyclohexyl]aMino]-4-[[4-(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione;Rawal Squaramide Organocatalyst;N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N'-[4-(trifluoromethyl)phenyl]squaramide 95%;3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4- (trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione,99%e.e.;3-(((1R,2R)-2-(Piperidin-1-yl)cyclohexyl)amino)-4-((4-(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione;3-Cyclobutene-1,2-dione, 3-[[(1R,2R)-2-(1-piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-;3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, 98%, (99% ee)

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aablocks
Chemenu
ChemScene
Sigma-Aldrich
Strem Chemicals
Synthonix

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50mg
100mg
250mg
500mg
1g

Manufactureraablocks
Product numberAA009ZUM
Product description3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione 97%
Packaging50mg
Price$48
Updated2026-05-28
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Manufactureraablocks
Product numberAA009ZUM
Product description3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione 97%
Packaging100mg
Price$52
Updated2026-05-28
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Manufactureraablocks
Product numberAA009ZUM
Product description3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione 97%
Packaging250mg
Price$129
Updated2026-05-28
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ManufacturerChemenu
Product numberCM681739
Product description3-(((1R,2R)-2-(Piperidin-1-yl)cyclohexyl)amino)-4-((4-(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione 95%+
Packaging1g
Price$697
Updated2026-05-20
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ManufacturerChemenu
Product numberCM681739
Product description3-(((1R,2R)-2-(Piperidin-1-yl)cyclohexyl)amino)-4-((4-(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione 95%+
Packaging1g
Price$697
Updated2026-05-26
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ManufacturerChemenu
Product numberCM681739
Product description3-(((1R,2R)-2-(Piperidin-1-yl)cyclohexyl)amino)-4-((4-(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione 95%+
Packaging250mg
Price$258
Updated2026-05-20
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ManufacturerChemenu
Product numberCM681739
Product description3-(((1R,2R)-2-(Piperidin-1-yl)cyclohexyl)amino)-4-((4-(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione 95%+
Packaging250mg
Price$258
Updated2026-05-26
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ManufacturerChemenu
Product numberCM681739
Product description3-(((1R,2R)-2-(Piperidin-1-yl)cyclohexyl)amino)-4-((4-(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione 95%+
Packaging100mg
Price$140
Updated2026-05-20
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ManufacturerChemenu
Product numberCM681739
Product description3-(((1R,2R)-2-(Piperidin-1-yl)cyclohexyl)amino)-4-((4-(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione 95%+
Packaging100mg
Price$140
Updated2026-05-26
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ManufacturerChemScene
Product numberCS-0092942
Product description3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione
Packaging100mg
Price$142
Updated2021-12-16
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ManufacturerSigma-Aldrich
Product number728357
Product descriptionN-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoromethyl)phenyl]squaramide 95%
Packaging100mg
Price$182
Updated2026-04-30
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ManufacturerSigma-Aldrich
Product number728357
Product descriptionN-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoromethyl)phenyl]squaramide 95%
Packaging500mg
Price$511
Updated2026-04-30
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ManufacturerStrem Chemicals
Product number07-1356
Product description3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, 98%, (99% ee)
Packaging50mg
Price$102
Updated2024-03-01
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ManufacturerStrem Chemicals
Product number07-1356
Product description3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, 98%, (99% ee) 98%,(99%ee)
Packaging50mg
Price$123
Updated2026-04-30
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ManufacturerSynthonix
Product numberP62907
Product description3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione >98%
Packaging100mg
Price$80
Updated2026-05-06
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Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
aablocks	AA009ZUM	3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione 97%	50mg	$48	2026-05-28	Buy
aablocks	AA009ZUM	3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione 97%	100mg	$52	2026-05-28	Buy
aablocks	AA009ZUM	3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione 97%	250mg	$129	2026-05-28	Buy
Chemenu	CM681739	3-(((1R,2R)-2-(Piperidin-1-yl)cyclohexyl)amino)-4-((4-(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione 95%+	1g	$697	2026-05-20	Buy
Chemenu	CM681739	3-(((1R,2R)-2-(Piperidin-1-yl)cyclohexyl)amino)-4-((4-(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione 95%+	1g	$697	2026-05-26	Buy
Chemenu	CM681739	3-(((1R,2R)-2-(Piperidin-1-yl)cyclohexyl)amino)-4-((4-(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione 95%+	250mg	$258	2026-05-20	Buy
Chemenu	CM681739	3-(((1R,2R)-2-(Piperidin-1-yl)cyclohexyl)amino)-4-((4-(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione 95%+	250mg	$258	2026-05-26	Buy
Chemenu	CM681739	3-(((1R,2R)-2-(Piperidin-1-yl)cyclohexyl)amino)-4-((4-(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione 95%+	100mg	$140	2026-05-20	Buy
Chemenu	CM681739	3-(((1R,2R)-2-(Piperidin-1-yl)cyclohexyl)amino)-4-((4-(trifluoromethyl)phenyl)amino)cyclobut-3-ene-1,2-dione 95%+	100mg	$140	2026-05-26	Buy
ChemScene	CS-0092942	3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione	100mg	$142	2021-12-16	Buy
Sigma-Aldrich	728357	N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoromethyl)phenyl]squaramide 95%	100mg	$182	2026-04-30	Buy
Sigma-Aldrich	728357	N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoromethyl)phenyl]squaramide 95%	500mg	$511	2026-04-30	Buy
Strem Chemicals	07-1356	3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, 98%, (99% ee)	50mg	$102	2024-03-01	Buy
Strem Chemicals	07-1356	3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione, 98%, (99% ee) 98%,(99%ee)	50mg	$123	2026-04-30	Buy
Synthonix	P62907	3-[[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]amino]-4-[[4-(trifluoromethyl)phenyl]amino]-3-cyclobutene-1,2-dione >98%	100mg	$80	2026-05-06	Buy

Properties

Melting point :250 °C (decomp)
Boiling point :497.4±55.0 °C(Predicted)
Density :1.31±0.1 g/cm3(Predicted)
storage temp. :2-8°C, protect from light, stored under nitrogen
pka :8.97±0.20(Predicted)
form :powder
Appearance :White to off-white Solid
optical activity :[α]/D -42.0±2.0°, c = 1 in DMSO
InChI :1S/C22H26F3N3O2/c23-22(24,25)14-8-10-15(11-9-14)26-18-19(21(30)20(18)29)27-16-6-2-3-7-17(16)28-12-4-1-5-13-28/h8-11,16-17,26-27H,1-7,12-13H2/t16-,17-/m1/s1
InChIKey :JRSCPJJNZMRAQS-IAGOWNOFSA-N
SMILES :C1(=O)C(NC2=CC=C(C(F)(F)F)C=C2)=C(N[C@@H]2CCCC[C@H]2N2CCCCC2)C1=O

Safety Information

Symbol(GHS):

Signal word:

Danger

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H318	Causes serious eye damage	Serious eye damage/eye irritation	Category 1	Danger	P280, P305+P351+P338, P310
H335	May cause respiratory irritation	Specific target organ toxicity, single exposure;Respiratory tract irritation	Category 3	Warning

Precautionary statements:

P280	Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352	IF ON SKIN: wash with plenty of soap and water.

Description

It can act as a catalyst for the asymmetric tandem aza-Michael addition-protonation between 1-nitro cyclohexene and 4-methoxyaniline to form the corresponding α-arylamino-β-nitro cyclohexane in a 35:65 trans/cis mixture.

More related product prices

3-[[(1S,2S)-2-(1-piperidinyl)cyclohexyl]aMino]-4-[[4-(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione 3-[[(9R)-6'-Methoxycinchonan-9-yl]aMino]-4-[[4-(trifluoroMethyl)phenyl]aMino]-3-Cyclobutene-1,2-dione 3-[[3,5-bis(trifluoroMethyl)phenyl]aMino]-4-[[(1R,2R)-2-(1-piperidinyl)cyclohexyl]aMino]-3-Cyclobutene-1,2-dione

Suppliers and manufacturers

Career Henan Chemica Co

Hangzhou MolCore BioPharmatech Co.,Ltd.

Aladdin Scientific Adamas Reagent, Ltd. Daicel Chiral Technologies (China)CO.,LTD Sigma-Aldrich Shanghai Chiral bio-compound co., Ltd. Shanghai YuanYe Biotechnology Co., Ltd. Greenherbs Science and Technology Development Co., Ltd. Aikon International Limited

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N-[(1R,2R)-2-(1-Piperidinyl)cyclohexyl]-N′-[4-(trifluoroMethyl)phenyl]squaraMide

Properties

Safety Information

Description

Related product price

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