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ChemicalBook >> CAS DataBase List >> S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide

S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide

S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide price.
  • $16 - $2800
  • Product name: S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide
  • CAS: 1346574-57-9
  • MF: C31H38N6O2
  • MW: 526.67
  • EINECS:-0
  • MDL Number:
  • Synonyms:S)-1-(sec-butyl)-N-((4,6-diMethyl-2-oxo-1,2-dihydropyridin-3-yl)Methyl)-3-Methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxaMide;N-[(4,6-Dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-((1S)-1-methylpropyl)-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide;GSK126, >=98%;1-(S)-sec-butyl-N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3-methyl-6-(6-(piperazin-1-yl)pyridin-3-yl)-1H-indole-4-carboxamide;GSK 126 N-[(4,6-Dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-((1S)-1-methylpropyl)-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide;N-[(4,6-Dimethyl-2-oxo-1,2-dihydro-3-pyridinyl)methyl]-3-methyl-1-((1S)-1-methylpropyl)-6-[6-(1-piperazinyl)-3-pyridinyl]-1H-indole-4-carboxamide GSK126;N-[(4,6-Dimethyl-2-ox;GSK126;GSK-126;GSK 126
76 prices
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Brand
  • aablocks
  • AK Scientific
  • ApexBio Technology
  • Apolloscientific
  • AvaChem
  • Axon Medchem
  • Biorbyt Ltd
  • Biosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Tocris
  • TRC
  • Usbiological
Package
  • 10mM*1mLinDMSO
  • 2mg
  • 1mg
  • 5
  • 5mg
  • 2x5mg
  • 10mg
  • 25mg
  • 50mg
  • 50.00mg
  • 100mg
  • 100.00mg
  • 200mg
  • 250.00mg
  • 250mg
  • 1000mg
  • 1g
  • Manufactureraablocks
  • Product numberAA009C97
  • Product description1H-Indole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]- 98%
  • Packaging1mg
  • Price$16
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA009C97
  • Product description1H-Indole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]- 98%
  • Packaging5mg
  • Price$33
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009C97
  • Product description1H-Indole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]- 98%
  • Packaging50mg
  • Price$124
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009C97
  • Product description1H-Indole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]- 98%
  • Packaging100mg
  • Price$196
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA009C97
  • Product description1H-Indole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]- 98%
  • Packaging250mg
  • Price$313
  • Updated2026-05-28
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  • ManufacturerAK Scientific
  • Product numberSYN5012
  • Product descriptionGSK126
  • Packaging50mg
  • Price$515
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA3446
  • Product descriptionGSK126
  • Packaging100mg
  • Price$400
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3446
  • Product descriptionGSK126
  • Packaging100mg
  • Price$400
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3446
  • Product descriptionGSK126
  • Packaging50mg
  • Price$290
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3446
  • Product descriptionGSK126
  • Packaging50mg
  • Price$280
  • Updated2026-05-06
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA3446
  • Product descriptionGSK126
  • Packaging10mg
  • Price$125
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA3446
  • Product descriptionGSK126
  • Packaging5mg
  • Price$78
  • Updated2026-05-06
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  • ManufacturerApexBio Technology
  • Product numberA3446
  • Product descriptionGSK126
  • Packaging5mg
  • Price$84
  • Updated2021-12-16
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  • ManufacturerApexBio Technology
  • Product numberA3446
  • Product descriptionGSK126
  • Packaging10mg
  • Price$115
  • Updated2026-05-06
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  • ManufacturerApolloscientific
  • Product numberBISN0124
  • Product descriptionGSK126 98%
  • Packaging5mg
  • Price$51
  • Updated2026-06-04
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  • ManufacturerApolloscientific
  • Product numberBISN0124
  • Product descriptionGSK126 98%
  • Packaging1mg
  • Price$25
  • Updated2026-06-04
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA009C97 1H-Indole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]- 98% 1mg $16 2026-05-28 Buy
aablocks AA009C97 1H-Indole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]- 98% 5mg $33 2026-05-28 Buy
aablocks AA009C97 1H-Indole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]- 98% 50mg $124 2026-05-28 Buy
aablocks AA009C97 1H-Indole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]- 98% 100mg $196 2026-05-28 Buy
aablocks AA009C97 1H-Indole-4-carboxamide, N-[(1,2-dihydro-4,6-dimethyl-2-oxo-3-pyridinyl)methyl]-3-methyl-1-[(1S)-1-methylpropyl]-6-[6-(1-piperazinyl)-3-pyridinyl]- 98% 250mg $313 2026-05-28 Buy
AK Scientific SYN5012 GSK126 50mg $515 2021-12-16 Buy
ApexBio Technology A3446 GSK126 100mg $400 2021-12-16 Buy
ApexBio Technology A3446 GSK126 100mg $400 2026-05-06 Buy
ApexBio Technology A3446 GSK126 50mg $290 2021-12-16 Buy
ApexBio Technology A3446 GSK126 50mg $280 2026-05-06 Buy
ApexBio Technology A3446 GSK126 10mg $125 2021-12-16 Buy
ApexBio Technology A3446 GSK126 5mg $78 2026-05-06 Buy
ApexBio Technology A3446 GSK126 5mg $84 2021-12-16 Buy
ApexBio Technology A3446 GSK126 10mg $115 2026-05-06 Buy
Apolloscientific BISN0124 GSK126 98% 5mg $51 2026-06-04 Buy
Apolloscientific BISN0124 GSK126 98% 1mg $25 2026-06-04 Buy

Properties

Melting point :>216°C (dec.)
Boiling point :823.4±65.0 °C(Predicted)
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :-20°C Freezer
solubility :DMSO (Slightly), Methanol (Slightly, Heated)
pka :11.93±0.10(Predicted)
form :Solid
color :Off-White
InChIKey :FKSFKBQGSFSOSM-QFIPXVFZSA-N
SMILES :N1([C@@H](C)CC)C2=C(C(C(NCC3=C(C)C=C(C)NC3=O)=O)=CC(C3=CC=C(N4CCNCC4)N=C3)=C2)C(C)=C1

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

The histone H3 lysine 27 (H3K27) methyltransferase EZH2 plays an important role in regulating gene expression, and its aberrant activity is linked to the onset and progression of cancer. GSK126 is a selective, S-adenosyl-methionine-competitive small molecule inhibitor of EZH2 methyltransferase activity (Ki = 0.57 nM; IC50 = 9.9 nM versus that of EZH1: Ki = 89 nM; IC50 = 680 nM). It is more than 1,000-fold selective for EZH2 over other histone methyltranferases, including both SET-domain-containing and non-SET-domain-containing methyltransferases. At concentrations of 7-252 nM, it has been shown to inhibit global H3K27 trimethylation levels and to reactivate silenced PRC2 target genes. Furthermore, GSK126 can inhibit the proliferation of EZH2 mutant DLBCL cell lines (IC50 = 28-61 nM) as well as the growth of EZH2 mutant DLBCL xenografts in mice receiving a daily dose of 50 mg/kg.

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