BISINDOLYLMALEIMIDE I HYDROCHLORIDE
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- $32 - $1001
- Product name: BISINDOLYLMALEIMIDE I HYDROCHLORIDE
- CAS: 176504-36-2
- MF: C25H25ClN4O2
- MW: 448.95
- EINECS:
- MDL Number:MFCD00236429
- Synonyms:BIM 1 hydrochloride;3-[1-(dimethylaminopropyl)indol-3-yl]-4-(indol-3-yl)maleimide hydrochloride;BisindolylMaleiMide I( Hydrochloride Salt);BisindolylMaleiMide I . hydrochloride [GF-109203K;3-[1-[3-(Dimethylamino)propyl]-1H-indol-3-yl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione monohydrochloride;3-[1-[3-(dimethylamino)propyl]indol-3-yl]-4-(1H-indol-3-yl)pyrrole-2,5-dione;Bisindolylmaleimide I, Hydrochloride - CAS 176504-36-2 - Calbiochem;GF 109203X hydrochloride >=95%
42 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- Adipogen Life Sciences
- AK Scientific
- American Custom Chemicals Corporation
- Apolloscientific
- Cayman Chemical
- Chemenu
- ChemScene
- Sigma-Aldrich
- Usbiological
Package
- 250ug
- 250μg
- 500μg
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- Manufactureraablocks
- Product numberAA0024NR
- Product description3-(1-(3-(Dimethylamino)Propyl)-1H-Indol-3-Yl)-4-(1H-Indol-3-Yl)-1H-Pyrrole-2,5-Dione Hydrochloride ≥98%
- Packaging1mg
- Price$55
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0024NR
- Product description3-(1-(3-(Dimethylamino)Propyl)-1H-Indol-3-Yl)-4-(1H-Indol-3-Yl)-1H-Pyrrole-2,5-Dione Hydrochloride ≥98%
- Packaging5mg
- Price$154
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0024NR
- Product description3-(1-(3-(Dimethylamino)Propyl)-1H-Indol-3-Yl)-4-(1H-Indol-3-Yl)-1H-Pyrrole-2,5-Dione Hydrochloride ≥98%
- Packaging10mg
- Price$247
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0024NR
- Product description3-(1-(3-(Dimethylamino)Propyl)-1H-Indol-3-Yl)-4-(1H-Indol-3-Yl)-1H-Pyrrole-2,5-Dione Hydrochloride ≥98%
- Packaging25mg
- Price$556
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA0024NR
- Product description3-(1-(3-(Dimethylamino)Propyl)-1H-Indol-3-Yl)-4-(1H-Indol-3-Yl)-1H-Pyrrole-2,5-Dione Hydrochloride ≥98%
- Packaging50mg
- Price$1001
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberY225657
- Product descriptionGF-109203X HCl 97.00%
- Packaging25MG
- Price$380
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberY225657
- Product descriptionGF-109203X HCl 97.00%
- Packaging10MG
- Price$190
- Updated2026-05-27
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0110-M001
- Product descriptionBisindolylmaleimide I . hydrochloride ≥98%(NMR)
- Packaging1mg
- Price$50
- Updated2026-05-06
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0110-M001
- Product descriptionBisindolylmaleimide I, Hydrochloride ≥98%(NMR)
- Packaging1mg
- Price$55
- Updated2021-12-16
- Buy
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-0110-M005
- Product descriptionBisindolylmaleimide I . hydrochloride ≥98%(NMR)
- Packaging5mg
- Price$150
- Updated2026-05-06
- Buy
- ManufacturerAK Scientific
- Product number8103CP
- Product descriptionBisindolylmaleimideI,HCl
- Packaging1mg
- Price$154
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000053
- Product descriptionBISINDOLYLMALEIMIDE I HYDROCHLORIDE 95.00%
- Packaging5MG
- Price$986.15
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberKIN0000053
- Product descriptionBISINDOLYLMALEIMIDE I HYDROCHLORIDE 95.00%
- Packaging1MG
- Price$498
- Updated2021-12-16
- Buy
- ManufacturerApolloscientific
- Product numberBIMI0497
- Product descriptionBisindolylmaleimide I hydrochloride 98%
- Packaging10mg
- Price$179
- Updated2026-06-04
- Buy
- ManufacturerApolloscientific
- Product numberBIMI0497
- Product descriptionBisindolylmaleimide I hydrochloride 98%
- Packaging25mg
- Price$387
- Updated2026-06-04
- Buy
- ManufacturerCayman Chemical
- Product number21180
- Product descriptionBisindolylmaleimide I (hydrochloride) ≥98%
- Packaging1mg
- Price$50
- Updated2024-03-01
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA0024NR | 3-(1-(3-(Dimethylamino)Propyl)-1H-Indol-3-Yl)-4-(1H-Indol-3-Yl)-1H-Pyrrole-2,5-Dione Hydrochloride ≥98% | 1mg | $55 | 2026-05-28 | Buy |
| aablocks | AA0024NR | 3-(1-(3-(Dimethylamino)Propyl)-1H-Indol-3-Yl)-4-(1H-Indol-3-Yl)-1H-Pyrrole-2,5-Dione Hydrochloride ≥98% | 5mg | $154 | 2026-05-28 | Buy |
| aablocks | AA0024NR | 3-(1-(3-(Dimethylamino)Propyl)-1H-Indol-3-Yl)-4-(1H-Indol-3-Yl)-1H-Pyrrole-2,5-Dione Hydrochloride ≥98% | 10mg | $247 | 2026-05-28 | Buy |
| aablocks | AA0024NR | 3-(1-(3-(Dimethylamino)Propyl)-1H-Indol-3-Yl)-4-(1H-Indol-3-Yl)-1H-Pyrrole-2,5-Dione Hydrochloride ≥98% | 25mg | $556 | 2026-05-28 | Buy |
| aablocks | AA0024NR | 3-(1-(3-(Dimethylamino)Propyl)-1H-Indol-3-Yl)-4-(1H-Indol-3-Yl)-1H-Pyrrole-2,5-Dione Hydrochloride ≥98% | 50mg | $1001 | 2026-05-28 | Buy |
| ACHEMBLOCK | Y225657 | GF-109203X HCl 97.00% | 25MG | $380 | 2026-05-27 | Buy |
| ACHEMBLOCK | Y225657 | GF-109203X HCl 97.00% | 10MG | $190 | 2026-05-27 | Buy |
| Adipogen Life Sciences | AG-CR1-0110-M001 | Bisindolylmaleimide I . hydrochloride ≥98%(NMR) | 1mg | $50 | 2026-05-06 | Buy |
| Adipogen Life Sciences | AG-CR1-0110-M001 | Bisindolylmaleimide I, Hydrochloride ≥98%(NMR) | 1mg | $55 | 2021-12-16 | Buy |
| Adipogen Life Sciences | AG-CR1-0110-M005 | Bisindolylmaleimide I . hydrochloride ≥98%(NMR) | 5mg | $150 | 2026-05-06 | Buy |
| AK Scientific | 8103CP | BisindolylmaleimideI,HCl | 1mg | $154 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000053 | BISINDOLYLMALEIMIDE I HYDROCHLORIDE 95.00% | 5MG | $986.15 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | KIN0000053 | BISINDOLYLMALEIMIDE I HYDROCHLORIDE 95.00% | 1MG | $498 | 2021-12-16 | Buy |
| Apolloscientific | BIMI0497 | Bisindolylmaleimide I hydrochloride 98% | 10mg | $179 | 2026-06-04 | Buy |
| Apolloscientific | BIMI0497 | Bisindolylmaleimide I hydrochloride 98% | 25mg | $387 | 2026-06-04 | Buy |
| Cayman Chemical | 21180 | Bisindolylmaleimide I (hydrochloride) ≥98% | 1mg | $50 | 2024-03-01 | Buy |
Properties
storage temp. :2-8°C
solubility :DMF: 10 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL
form :Orange-red solid
color :Orange to red
biological source :synthetic (organic)
Water Solubility :water: 10mg/mL
DMSO: 20mg/mL InChIKey :XRAMWNCMYJHGGH-UHFFFAOYSA-N
SMILES :Cl.CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15
solubility :DMF: 10 mg/mL; DMSO: 16 mg/mL; DMSO:PBS(pH 7.2) (1:4): 0.2 mg/mL
form :Orange-red solid
color :Orange to red
biological source :synthetic (organic)
Water Solubility :water: 10mg/mL
DMSO: 20mg/mL InChIKey :XRAMWNCMYJHGGH-UHFFFAOYSA-N
SMILES :Cl.CN(C)CCCn1cc(C2=C(C(=O)NC2=O)c3c[nH]c4ccccc34)c5ccccc15
Safety Information
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| Signal word: | Warning | ||||||||||||||
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Description
Bisindolylmaleimide I (BIM I) is a highly selective, cell-permeable, and reversible PKC inhibitor (Ki = 14 nM) that is structurally similar to the poorly selective PKC inhibitor staurosporine . It acts as a competitive inhibitor for the ATP binding site of PKC and shows high selectivity for PKCα, β1, β2, γ, δ, and ε isozymes. BIM I directly inhibits glycogen synthase kinase 3 (GSK3) in primary adipocyte lysates (IC50 = 360 nM) and in GSK3β immunoprecipitates derived from rat epididymal adipocytes (IC50 = 170 nM). It also competitively antagonizes the serotonin (5-HT) receptor subtype 5-HT3 with a Ki value of 61 nM.More related product prices
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