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ChemicalBook >> CAS DataBase List >> (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide

(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide

(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide price.
  • $16 - $3068
  • Product name: (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide
  • CAS: 432531-71-0
  • MF: C18H15N5O6S2
  • MW: 461.47
  • EINECS:
  • MDL Number:
  • Synonyms:(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide;Necrosulfonami;N-[4-[[(3-Methoxypyrazinyl)aMino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-2-propenaMide;(E)-N-[4-[(3-methoxypyrazin-2-yl)sulfamoyl]phenyl]-3-(5-nitrothiophen-2-yl)prop-2-enamide;MLKL Inhibitor, Necrosulfonamide - CAS 432531-71-0 - Calbiochem;Necrosulfonamide(b);2-Propenamide, N-[4-[[(3-methoxy-2-pyrazinyl)amino]sulfonyl]phenyl]-3-(5-nitro-2-thienyl)-;(E/Z)-Necrosulfonamide
41 prices
Selected condition:
Brand
  • aablocks
  • Arctom
  • Biosynth
  • Chemenu
  • ChemScene
  • CSNpharm
  • Matrix Scientific
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TRC
  • Usbiological
Package
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 1mg
  • 10mM*1mLinDMSO(Solution)
  • 5mg
  • 10mg
  • 10.00mg
  • 25mg
  • 25.00mg
  • 50mg
  • 50.00mg
  • 100mg
  • 0.5g
  • Manufactureraablocks
  • Product numberAA00DEZZ
  • Product description(E/Z)-Necrosulfonamide 98%
  • Packaging1mg
  • Price$16
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00DEZZ
  • Product description(E/Z)-Necrosulfonamide 98%
  • Packaging5mg
  • Price$33
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00DEZZ
  • Product description(E/Z)-Necrosulfonamide 98%
  • Packaging10mg
  • Price$54
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00DEZZ
  • Product description(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide 98+%
  • Packaging5mg
  • Price$104
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA00DEZZ
  • Product description(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide 98+%
  • Packaging10mg
  • Price$147
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA00DEZZ
  • Product description(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide 98+%
  • Packaging25mg
  • Price$222
  • Updated2021-12-16
  • Buy
  • Manufactureraablocks
  • Product numberAA00DEZZ
  • Product description(E/Z)-Necrosulfonamide 98%
  • Packaging25mg
  • Price$90
  • Updated2026-05-28
  • Buy
  • Manufactureraablocks
  • Product numberAA00DEZZ
  • Product description(E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide 98+%
  • Packaging50mg
  • Price$348
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberHY-100573A
  • Product description(E/Z)-Necrosulfonamide 98.03%
  • Packaging50mg
  • Price$342
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-100573A
  • Product description(E/Z)-Necrosulfonamide 98.03%
  • Packaging100mg
  • Price$513
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-100573A
  • Product description(E/Z)-Necrosulfonamide 98.03%
  • Packaging25mg
  • Price$228
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-100573A
  • Product description(E/Z)-Necrosulfonamide 98.03%
  • Packaging10mg
  • Price$119
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-100573A
  • Product description(E/Z)-Necrosulfonamide 98.03%
  • Packaging5mg
  • Price$76
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-100573A
  • Product description(E/Z)-Necrosulfonamide 98.03%
  • Packaging10mM*1mLinDMSO(Solution)
  • Price$77
  • Updated2026-05-26
  • Buy
  • ManufacturerArctom
  • Product numberHY-100573A
  • Product description(E/Z)-Necrosulfonamide 98.03%
  • Packaging10mM*1mLinDMSO(Solid+Solvent)
  • Price$74
  • Updated2026-05-26
  • Buy
  • ManufacturerBiosynth
  • Product numberHSA53171
  • Product descriptionMLKL Inhibitor, Necrosulfonamide
  • Packaging50mg
  • Price$958
  • Updated2026-06-04
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00DEZZ (E/Z)-Necrosulfonamide 98% 1mg $16 2026-05-28 Buy
aablocks AA00DEZZ (E/Z)-Necrosulfonamide 98% 5mg $33 2026-05-28 Buy
aablocks AA00DEZZ (E/Z)-Necrosulfonamide 98% 10mg $54 2026-05-28 Buy
aablocks AA00DEZZ (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide 98+% 5mg $104 2021-12-16 Buy
aablocks AA00DEZZ (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide 98+% 10mg $147 2021-12-16 Buy
aablocks AA00DEZZ (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide 98+% 25mg $222 2021-12-16 Buy
aablocks AA00DEZZ (E/Z)-Necrosulfonamide 98% 25mg $90 2026-05-28 Buy
aablocks AA00DEZZ (E)-N-[4-[N-(3-Methoxypyrazin-2-yl)sulfaMoyl]phenyl]-3-(5-nitrothiophene-2-yl)acrylaMide 98+% 50mg $348 2021-12-16 Buy
Arctom HY-100573A (E/Z)-Necrosulfonamide 98.03% 50mg $342 2026-05-26 Buy
Arctom HY-100573A (E/Z)-Necrosulfonamide 98.03% 100mg $513 2026-05-26 Buy
Arctom HY-100573A (E/Z)-Necrosulfonamide 98.03% 25mg $228 2026-05-26 Buy
Arctom HY-100573A (E/Z)-Necrosulfonamide 98.03% 10mg $119 2026-05-26 Buy
Arctom HY-100573A (E/Z)-Necrosulfonamide 98.03% 5mg $76 2026-05-26 Buy
Arctom HY-100573A (E/Z)-Necrosulfonamide 98.03% 10mM*1mLinDMSO(Solution) $77 2026-05-26 Buy
Arctom HY-100573A (E/Z)-Necrosulfonamide 98.03% 10mM*1mLinDMSO(Solid+Solvent) $74 2026-05-26 Buy
Biosynth HSA53171 MLKL Inhibitor, Necrosulfonamide 50mg $958 2026-06-04 Buy

Properties

storage temp. :+2C to +8C
solubility :DMSO:100.0(Max Conc. mg/mL);216.7(Max Conc. mM)
form :Dark yellow solid
color :Light yellow to yellow
InChI :1S/C18H15N5O6S2/c1-29-18-17(19-10-11-20-18)22-31(27,28)14-6-2-12(3-7-14)21-15(24)8-4-13-5-9-16(30-13)23(25)26/h2-11H,1H3,(H,19,22)(H,21,24)/b8-4+
InChIKey :FNPPHVLYVGMZMZ-XBXARRHUSA-N
SMILES :[S](=O)(=O)(Nc3ncc[n+H]c3OC)c1ccc(cc1)\N=C(/[O-])\C=C\c2[s]c(cc2)[N+](=O)[O-]

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Necrosulfonamide specifically blocks necrosis downstream of receptor-interacting serine-threonine kinase 3 (RIP3) activation. RIP3 is a key signalling molecule in the programmed necrosis (necroptosis) pathway.

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