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ChemicalBook >> CAS DataBase List >> [4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID

[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID

[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID price.
  • $16 - $1600
  • Product name: [4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID
  • CAS: 475085-57-5
  • MF: C25H29N3O3
  • MW: 419.52
  • EINECS:
  • MDL Number:MFCD11976884
  • Synonyms:[4-[(5,6-DIPHENYLPYRAZINYL)(1-METHYLETHYL)AMINO]BUTOXY]-ACETIC ACID;ACT 333679;2-{4-[N-(5,6-diphenylpyrazin-2-yl)-N-isopropylamino]butyloxy}acetic acid;Selexipag Active Metabolite (ACT-333679);{4-[(5,6-Diphenyl-2-pyrazinyl)(isopropyl)amino]butoxy}acetic acid;MRE-269 (ACT-333679);MRE-269 Selexipag Active Metabolite;MRE-269 S
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  • aablocks
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  • Biorbyt Ltd
  • Cayman Chemical
  • Chemenu
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  • DC Chemicals
  • Matrix Scientific
  • TRC
  • Usbiological
Package
  • 10mM*1mLinDMSO
  • 1mg
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  • 250.00mg
  • 250mg
  • 1.00g
  • 1mlx10mM(inDMSO)
  • 10mM*1mLinDMSO(Solid+Solvent)
  • 1g
  • 5g
  • 10mM*1mLinDMSO(Solution)
  • 5.00g
  • Manufactureraablocks
  • Product numberAA00DA7Y
  • Product description[4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid 98%
  • Packaging1mg
  • Price$16
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00DA7Y
  • Product description[4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid 98%
  • Packaging5mg
  • Price$19
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00DA7Y
  • Product description[4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid 98%
  • Packaging10mg
  • Price$23
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00DA7Y
  • Product description[4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid 98%
  • Packaging25mg
  • Price$28
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00DA7Y
  • Product description[4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid 98%
  • Packaging250mg
  • Price$49
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00DA7Y
  • Product description[4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid 98%(HPLC)
  • Packaging50mg
  • Price$30
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00DA7Y
  • Product description[4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid 98%(HPLC)
  • Packaging100mg
  • Price$39
  • Updated2026-05-28
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  • Manufactureraablocks
  • Product numberAA00DA7Y
  • Product description[4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid 98%
  • Packaging1g
  • Price$102
  • Updated2026-05-28
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  • ManufacturerACHEMBLOCK
  • Product numberY228156
  • Product descriptionMRE-269 97.00%
  • Packaging50MG
  • Price$235
  • Updated2026-05-27
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  • ManufacturerAK Scientific
  • Product numberY0263
  • Product description(4-((5,6-Diphenylpyrazinyl)(1-methylethyl)amino)butoxy)-aceticacid
  • Packaging5mg
  • Price$194
  • Updated2021-12-16
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  • ManufacturerArctom
  • Product numberHY-79593
  • Product descriptionMRE-269 99.14%
  • Packaging25mg
  • Price$178
  • Updated2026-05-26
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  • ManufacturerArctom
  • Product numberHY-79593
  • Product descriptionMRE-269 99.14%
  • Packaging50mg
  • Price$238
  • Updated2026-05-26
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  • ManufacturerArctom
  • Product numberHY-79593
  • Product descriptionMRE-269 99.14%
  • Packaging100mg
  • Price$428
  • Updated2026-05-26
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  • ManufacturerArctom
  • Product numberHY-79593
  • Product descriptionMRE-269 99.14%
  • Packaging5mg
  • Price$57
  • Updated2026-05-26
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  • ManufacturerArctom
  • Product numberHY-79593
  • Product descriptionMRE-269 99.14%
  • Packaging10mM*1mLinDMSO(Solid+Solvent)
  • Price$60
  • Updated2026-05-26
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  • ManufacturerArctom
  • Product numberHY-79593
  • Product descriptionMRE-269 99.14%
  • Packaging10mg
  • Price$105
  • Updated2026-05-26
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Manufacturer Product number Product description Packaging Price Updated Buy
aablocks AA00DA7Y [4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid 98% 1mg $16 2026-05-28 Buy
aablocks AA00DA7Y [4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid 98% 5mg $19 2026-05-28 Buy
aablocks AA00DA7Y [4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid 98% 10mg $23 2026-05-28 Buy
aablocks AA00DA7Y [4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid 98% 25mg $28 2026-05-28 Buy
aablocks AA00DA7Y [4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid 98% 250mg $49 2026-05-28 Buy
aablocks AA00DA7Y [4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid 98%(HPLC) 50mg $30 2026-05-28 Buy
aablocks AA00DA7Y [4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid 98%(HPLC) 100mg $39 2026-05-28 Buy
aablocks AA00DA7Y [4-[(5,6-diphenylpyrazinyl)(1-methylethyl)amino]butoxy]-acetic acid 98% 1g $102 2026-05-28 Buy
ACHEMBLOCK Y228156 MRE-269 97.00% 50MG $235 2026-05-27 Buy
AK Scientific Y0263 (4-((5,6-Diphenylpyrazinyl)(1-methylethyl)amino)butoxy)-aceticacid 5mg $194 2021-12-16 Buy
Arctom HY-79593 MRE-269 99.14% 25mg $178 2026-05-26 Buy
Arctom HY-79593 MRE-269 99.14% 50mg $238 2026-05-26 Buy
Arctom HY-79593 MRE-269 99.14% 100mg $428 2026-05-26 Buy
Arctom HY-79593 MRE-269 99.14% 5mg $57 2026-05-26 Buy
Arctom HY-79593 MRE-269 99.14% 10mM*1mLinDMSO(Solid+Solvent) $60 2026-05-26 Buy
Arctom HY-79593 MRE-269 99.14% 10mg $105 2026-05-26 Buy

Properties

Melting point :116 - 118°C
Boiling point :602.1±55.0 °C(Predicted)
Density :1.160
storage temp. :Hygroscopic, -20°C Freezer, Under inert atmosphere
solubility :Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka :3.51±0.10(Predicted)
form :Solid
color :Off-White to Light Yellow
InChI :1S/C25H29N3O3/c1-19(2)28(15-9-10-16-31-18-23(29)30)22-17-26-24(20-11-5-3-6-12-20)25(27-22)21-13-7-4-8-14-21/h3-8,11-14,17,19H,9-10,15-16,18H2,1-2H3,(H,29,30)
InChIKey :OJQMKCBWYCWFPU-UHFFFAOYSA-N
SMILES :C(O)(=O)COCCCCN(C1=NC(C2=CC=CC=C2)=C(C2=CC=CC=C2)N=C1)C(C)C

Safety Information

Symbol(GHS): Exclamation Mark (GHS07)
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Prostacyclin (PGI2) is a potent vasorelaxant and inhibitor of platelet aggregation. It mediates its actions by binding to a specific G protein-coupled receptor, the IP receptor, on the surface of endothelial cells, arterial smooth muscle, and platelets. The IP receptor also participates in signal transduction of the pain response, cardioprotection, and inflammation. MRE-269 is the active form of the prodrug NS-304. It is a potent and selective agonist for the human IP receptor with a Ki value of 20 nM. In contrast to PGI2, which has a half-life of 30 seconds to a few minutes in vivo, plasma concentrations of MRE-269 remain near peak levels for more than eight hours in rats and dogs. Unlike the PGI2 analogues, beraprost and iloprost, MRE-269 lacks high affinity for the EP3 receptor. As a result, MRE-269 induces vasodilation equally in large and small pulmonary arteries, whereas vasodilation of small arteries by beraprost and iloprost is reduced via EP3-mediated vasoconstriction.

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