ABT-639
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- $16 - $2520
- Product name: ABT-639
- CAS: 1235560-28-7
- MF: C20H20ClF2N3O3S
- MW: 455.91
- EINECS:
- MDL Number:MFCD29924737
- Synonyms:ABT-639;4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide;4-CHLORO-2-FLURO-N-(2-FLUOROPHENYL)-5-[(8AR)-HEXAHYDROPYRROLO[1,2-A]PYRAZIN-2(1H)-YLCARBONYL]BENZENESULFONAMIDE;ABT-639, CID 46851313;(R)-4-chloro-2-fluoro-N-(2-fluorophenyl)-5-(octahydropyrrolo[1,2-a]pyrazine-2-carbonyl)benzenesulfonamide;ABT-639 (ABT639;CS-2286;ABT-693
50 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- Axon Medchem
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- Tocris
Package
- 10mM*1mLinDMSO
- 1mg
- 5mg
- 10
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1G
- Manufactureraablocks
- Product numberAA000KPR
- Product description4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide 98%
- Packaging1mg
- Price$16
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000KPR
- Product description4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide 98
- Packaging5mg
- Price$56
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000KPR
- Product description4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide 98
- Packaging10mg
- Price$79
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000KPR
- Product description4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide 98
- Packaging50mg
- Price$258
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000KPR
- Product description4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide 98
- Packaging25mg
- Price$158
- Updated2026-05-25
- Buy
- Manufactureraablocks
- Product numberAA000KPR
- Product description4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide 98
- Packaging100mg
- Price$415
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72383
- Product descriptionABT-639 98%
- Packaging1G
- Price$1685
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72383
- Product descriptionABT-639 98%
- Packaging1G
- Price$1685
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72383
- Product descriptionABT-639 98%
- Packaging100MG
- Price$350
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72383
- Product descriptionABT-639 98%
- Packaging100MG
- Price$350
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72383
- Product descriptionABT-639 98%
- Packaging5MG
- Price$45
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72383
- Product descriptionABT-639 98%
- Packaging5MG
- Price$45
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72383
- Product descriptionABT-639 98%
- Packaging25MG
- Price$125
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberS72383
- Product descriptionABT-639 98%
- Packaging25MG
- Price$125
- Updated2026-05-27
- Buy
- ManufacturerAK Scientific
- Product number8455DG
- Product descriptionAbt-639
- Packaging5mg
- Price$289
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon3785
- Product descriptionABT-639 99%
- Packaging5mg
- Price$126.5
- Updated2026-05-19
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA000KPR | 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide 98% | 1mg | $16 | 2026-05-25 | Buy |
| aablocks | AA000KPR | 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide 98 | 5mg | $56 | 2026-05-25 | Buy |
| aablocks | AA000KPR | 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide 98 | 10mg | $79 | 2026-05-25 | Buy |
| aablocks | AA000KPR | 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide 98 | 50mg | $258 | 2026-05-25 | Buy |
| aablocks | AA000KPR | 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide 98 | 25mg | $158 | 2026-05-25 | Buy |
| aablocks | AA000KPR | 4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]carbonyl]benzenesulfonamide 98 | 100mg | $415 | 2026-05-25 | Buy |
| ACHEMBLOCK | S72383 | ABT-639 98% | 1G | $1685 | 2026-05-25 | Buy |
| ACHEMBLOCK | S72383 | ABT-639 98% | 1G | $1685 | 2026-05-27 | Buy |
| ACHEMBLOCK | S72383 | ABT-639 98% | 100MG | $350 | 2026-05-27 | Buy |
| ACHEMBLOCK | S72383 | ABT-639 98% | 100MG | $350 | 2026-05-25 | Buy |
| ACHEMBLOCK | S72383 | ABT-639 98% | 5MG | $45 | 2026-05-25 | Buy |
| ACHEMBLOCK | S72383 | ABT-639 98% | 5MG | $45 | 2026-05-27 | Buy |
| ACHEMBLOCK | S72383 | ABT-639 98% | 25MG | $125 | 2026-05-25 | Buy |
| ACHEMBLOCK | S72383 | ABT-639 98% | 25MG | $125 | 2026-05-27 | Buy |
| AK Scientific | 8455DG | Abt-639 | 5mg | $289 | 2021-12-16 | Buy |
| Axon Medchem | Axon3785 | ABT-639 99% | 5mg | $126.5 | 2026-05-19 | Buy |
Properties
Boiling point :612.2±65.0 °C(Predicted)
Density :1.51±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:9.71(Max Conc. mg/mL);21.3(Max Conc. mM)
DMF:14.0(Max Conc. mg/mL);30.71(Max Conc. mM)
DMF:PBS (pH 7.2) (1:20):0.04(Max Conc. mg/mL);0.09(Max Conc. mM)
Ethanol:0.5(Max Conc. mg/mL);1.1(Max Conc. mM) form :A solid
pka :6.80±0.10(Predicted)
color :White to off-white
InChIKey :AGPIHNZOZNKRGT-CYBMUJFWSA-N
SMILES :Fc1c(cc(c(c1)Cl)C(=O)N3C[C@@H]4N(CC3)CCC4)[S](=O)(=O)Nc2c(cccc2)F
Density :1.51±0.1 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO:9.71(Max Conc. mg/mL);21.3(Max Conc. mM)
DMF:14.0(Max Conc. mg/mL);30.71(Max Conc. mM)
DMF:PBS (pH 7.2) (1:20):0.04(Max Conc. mg/mL);0.09(Max Conc. mM)
Ethanol:0.5(Max Conc. mg/mL);1.1(Max Conc. mM) form :A solid
pka :6.80±0.10(Predicted)
color :White to off-white
InChIKey :AGPIHNZOZNKRGT-CYBMUJFWSA-N
SMILES :Fc1c(cc(c(c1)Cl)C(=O)N3C[C@@H]4N(CC3)CCC4)[S](=O)(=O)Nc2c(cccc2)F
Safety Information
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| Signal word: | Warning | |||||||||||||||||||||
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Description
ABT-639 is a T-type calcium channel blocker. It inhibits inactivated-state Cav3.2 channels with an IC50 value of 2.3 μM and inactivated-state Cav3.1 and Cav3.3 channels by 50 and 39%, respectively, when used at a concentration of 10 μM. ABT-639 selectively inhibits inactivated-state T-type calcium currents over resting-state currents in rat dorsal root ganglion (DRG) neurons (IC50s = 7.6 and >30 μM, respectively). It reverses the hind limb grip force deficit in a rat model of osteoarthritic pain induced by monoiodoacetic acid (MIA; ED50 = 2 mg/kg). ABT-639 also increases the paw withdrawal threshold in rat spinal nerve ligation (SNL) and chronic constriction injury (CCI) models of neuropathic pain in a dose-dependent manner and attenuates cold allodynia in the CCI rat model when administered at doses greater than or equal to 3 mg/kg.More related product prices
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![4-Chloro-2-fluoro-N-(2-fluorophenyl)-5-[(8aR)-hexahydropyrrolo[1,2-a]pyrazin-2(1H)-ylcarbonyl]benzenesulfonamide](https://img.chemicalbook.com/ProductImageEN/2019-12/small/b2f8639f-3ce0-41ed-982d-01ee7f83faea.png){kind=small}
