AVL-292
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- $44 - $1949.9
- Product name: AVL-292
- CAS: 1202757-89-8
- MF: C22H22FN5O3
- MW: 423.44
- EINECS:
- MDL Number:MFCD25976876
- Synonyms:AVL-292;LMK-435;N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide;2-Propenamide, N-[3-[[5-fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-;CC-292 (AVL-292);CC-292,LMK-435;N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide AVL292;AVL-292 (Spebrutinib)
61 prices
Selected condition：
Brand
- aablocks
- ACHEMBLOCK
- AK Scientific
- ApexBio Technology
- Arctom
- Axon Medchem
- Biorbyt Ltd
- Biosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 10mM*1mLinDMSO(Solid+Solvent)
- 1mg
- 10mM*1mLinDMSO(Solution)
- 2x5mg
- 25mg
- 0.25g
- 50mg
- 10mM*1mLinDMSO
- 10mM(in 1mL DMSO)
- 2mg
- 5mg
- 10mg
- 100mg
- 250mg
- 1g
- 10mM(in1mLDMSO)
- Manufactureraablocks
- Product numberAA003A3S
- Product descriptionN-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide 98
- Packaging2mg
- Price$48
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003A3S
- Product descriptionN-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide 98+%
- Packaging100mg
- Price$60
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003A3S
- Product descriptionN-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide 98+%
- Packaging250mg
- Price$117
- Updated2026-05-28
- Buy
- Manufactureraablocks
- Product numberAA003A3S
- Product descriptionN-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide 98%
- Packaging1g
- Price$290
- Updated2026-05-28
- Buy
- ManufacturerACHEMBLOCK
- Product numberH-8741
- Product descriptionAVL-292 98%
- Packaging1G
- Price$340
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberH-8741
- Product descriptionAVL-292 98%
- Packaging1G
- Price$340
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberH-8741
- Product descriptionAVL-292 98%
- Packaging250MG
- Price$130
- Updated2026-05-25
- Buy
- ManufacturerACHEMBLOCK
- Product numberH-8741
- Product descriptionAVL-292 98%
- Packaging250MG
- Price$130
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberH-8741
- Product descriptionAVL-292 98%
- Packaging100MG
- Price$65
- Updated2026-05-27
- Buy
- ManufacturerACHEMBLOCK
- Product numberH-8741
- Product descriptionAVL-292 98%
- Packaging100MG
- Price$65
- Updated2026-05-25
- Buy
- ManufacturerAK Scientific
- Product number2235AH
- Product descriptionN-[3-[[5-Fluoro-2-[4-(2-methoxyethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide
- Packaging5mg
- Price$142
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3206
- Product descriptionAVL-292
- Packaging10mM(in 1mL DMSO)
- Price$88
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3206
- Product descriptionAVL-292
- Packaging10mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA3206
- Product descriptionAVL-292
- Packaging10mg
- Price$79
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3206
- Product descriptionAVL-292
- Packaging10mM(in1mLDMSO)
- Price$88
- Updated2026-05-06
- Buy
- ManufacturerApexBio Technology
- Product numberA3206
- Product descriptionAVL-292
- Packaging50mg
- Price$350
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| aablocks | AA003A3S | N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide 98 | 2mg | $48 | 2026-05-28 | Buy |
| aablocks | AA003A3S | N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide 98+% | 100mg | $60 | 2026-05-28 | Buy |
| aablocks | AA003A3S | N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide 98+% | 250mg | $117 | 2026-05-28 | Buy |
| aablocks | AA003A3S | N-[3-[[5-Fluoro-2-[[4-(2-methoxyethoxy)phenyl]amino]-4-pyrimidinyl]amino]phenyl]-2-propenamide 98% | 1g | $290 | 2026-05-28 | Buy |
| ACHEMBLOCK | H-8741 | AVL-292 98% | 1G | $340 | 2026-05-25 | Buy |
| ACHEMBLOCK | H-8741 | AVL-292 98% | 1G | $340 | 2026-05-27 | Buy |
| ACHEMBLOCK | H-8741 | AVL-292 98% | 250MG | $130 | 2026-05-25 | Buy |
| ACHEMBLOCK | H-8741 | AVL-292 98% | 250MG | $130 | 2026-05-27 | Buy |
| ACHEMBLOCK | H-8741 | AVL-292 98% | 100MG | $65 | 2026-05-27 | Buy |
| ACHEMBLOCK | H-8741 | AVL-292 98% | 100MG | $65 | 2026-05-25 | Buy |
| AK Scientific | 2235AH | N-[3-[[5-Fluoro-2-[4-(2-methoxyethoxy)anilino]pyrimidin-4-yl]amino]phenyl]prop-2-enamide | 5mg | $142 | 2021-12-16 | Buy |
| ApexBio Technology | A3206 | AVL-292 | 10mM(in 1mL DMSO) | $88 | 2021-12-16 | Buy |
| ApexBio Technology | A3206 | AVL-292 | 10mg | $120 | 2021-12-16 | Buy |
| ApexBio Technology | A3206 | AVL-292 | 10mg | $79 | 2026-05-06 | Buy |
| ApexBio Technology | A3206 | AVL-292 | 10mM(in1mLDMSO) | $88 | 2026-05-06 | Buy |
| ApexBio Technology | A3206 | AVL-292 | 50mg | $350 | 2021-12-16 | Buy |
Properties
Density :1.322±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :≥21.15 mg/mL in DMSO; insoluble in H2O; ≥4.9 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :13.22±0.70(Predicted)
color :White to khaki
InChIKey :KXBDTLQSDKGAEB-UHFFFAOYSA-N
SMILES :C(NC1=CC=CC(NC2C(F)=CN=C(NC3=CC=C(OCCOC)C=C3)N=2)=C1)(=O)C=C
CAS DataBase Reference :1202757-89-8
storage temp. :Store at -20°C
solubility :≥21.15 mg/mL in DMSO; insoluble in H2O; ≥4.9 mg/mL in EtOH with gentle warming and ultrasonic
form :solid
pka :13.22±0.70(Predicted)
color :White to khaki
InChIKey :KXBDTLQSDKGAEB-UHFFFAOYSA-N
SMILES :C(NC1=CC=CC(NC2C(F)=CN=C(NC3=CC=C(OCCOC)C=C3)N=2)=C1)(=O)C=C
CAS DataBase Reference :1202757-89-8
Safety Information
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Description
Bruton’s tyrosine kinase (BTK) is a non-receptor tyrosine kinase involved in signal transduction pathways regulating the proliferation, activation, and differentiation of B cells. AVL-292 is an orally available, selective, and irreversible inhibitor of BTK (IC50 = 0.5 nM in vitro in B cell lymphoma cell lines) that targets and covalently binds to BTK at cysteine-481, thereby preventing its activity. AVL-292 has been shown to inhibit osteoclast function and to reduce osteoclast-stimulated proliferation of multiple myeloma cells in animal models of rheumatoid arthritis and multiple sclerosis, both of which are diseases where B cells play an important role. In clinical trials, AVL-292 has demonstrated therapeutic significance in the treatment of both B cell-related cancers (e.g., non-Hodgkin’s lymphoma and B cell chronic lymphocytic leukemia) and autoimmune diseases (e.g., rheumatoid arthritis).Suppliers and manufacturers
Zhejiang J&C Biological Technology Co.,Limited
ATK CHEMICAL COMPANY LIMITED
Zhejiang ZETian Fine Chemicals Co. LTD
Biochempartner
TargetMol Chemicals Inc.
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Dideu Industries Group Limited
BOC Sciences
Henan Alfa Chemical Co., Ltd
AVL-292
CAS:1202757-89-8